iiinova — where your digital self keeps evolving

Reposted by Possu Huang Lab

Pauline Funchain @funchainmd.bsky.social · 04/11/2025

Ever wonder why our HLA specified cancer therapies are only for HLA02:01 thus far? @possuhuanglab.bsky.social presents the scope of the problem at the inaugural @stanford-cancer.bsky.social AI and Cancer Research Symposium 🧬

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Possu Huang Lab @possuhuanglab.bsky.social · 09/10/2025

Introducing SLAE, our new framework to represent all-atom protein structures with residue local chemical environment tokens! SLAE reasons over atomic interactions to recover structures and residue pairwise energetics, yielding a generalizable, physics-informed latent space. (1/8)

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Possu Huang Lab @possuhuanglab.bsky.social · 19/08/2025

We have a new collection of protein structure generative models which we call Protpardelle-1c. It builds on the original Protpardelle and is tailored for conditional generation: motif scaffolding and binder generation.

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Possu Huang Lab @possuhuanglab.bsky.social · 29/07/2025

SHAPES now published in Cell Systems!

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Reposted by Possu Huang Lab

Kevin K. Yang 楊凱筌 @kevinkaichuang.bsky.social · 21/02/2025

All-atom fixed backbone protein sequence design with FAMPNN @richardshuai.bsky.social Talal Widatalla @possuhuanglab.bsky.social @brianhie.bsky.social www.biorxiv.org/content/10.1...

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Reposted by Possu Huang Lab

Kevin K. Yang 楊凱筌 @kevinkaichuang.bsky.social · 15/01/2025

A framework for evaluating how well generative models of protein structure match the distribution of natural structures. @possuhuanglab.bsky.social www.biorxiv.org/content/10.1...

Generative models capture a biased set of protein structure space

Generative models do not capture the full expressivity of PDB structures

Protein structure embeddings reveal undersampled and de novo structure space

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Possu Huang Lab @possuhuanglab.bsky.social · 15/01/2025

New preprint from our group! We propose SHAPES, a set of metrics to quantify the distributional coverage of generative models of protein structures with embeddings at different structural hierarchies and quantify undersampling / extrapolation behaviors.

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Reposted by Possu Huang Lab

Daniel Hoces @dhoces.bsky.social · 17/12/2024

This is a clever way to use synthetic biology: taking a toxin that overactivate the immune system (superantigen), rationally modify its core components and transform it into a platform of immunotherapy agents. Congratulations to @haotiandu.bsky.social and @possuhuanglab.bsky.social on the 2 papers!

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Reposted by Possu Huang Lab

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 17/12/2024

Checkout out these two bombshell papers from @possuhuanglab.bsky.social @stanfordmedicine.bsky.social, computational design of antigen-specific binders to MHC-I or -II, with applications to next gen targeted therapeutics 🤯

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Reposted by Possu Huang Lab

Stanford Department of Bioengineering @bioe-stanford.bsky.social · 17/12/2024

Science in 60 Seconds: Haotian Du, PhD student with Possu Huang’s lab, explains her research on creating novel proteins that expands the possibilities for detecting more cancer types. @possuhuanglab.bsky.social @haotiandu.bsky.social

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Reposted by Possu Huang Lab

Stanford Department of Bioengineering @bioe-stanford.bsky.social · 17/12/2024

Incredible work from BioE Professor’s Possu Huang Lab @possuhuanglab.bsky.social @haotiandu.bsky.social - pioneering novel proteins with new structures and functions, unlocking new possibilities for detecting more cancer types. Congratulations!

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Reposted by Possu Huang Lab

haotiandu.bsky.social @haotiandu.bsky.social · 17/12/2024

Excited to share that TRACeR stories are out🙌

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Reposted by Possu Huang Lab

Jon Douglas @atranscendedman.bsky.social · 15/12/2024

A new system, TRACeR-I, targets peptides on MHC I molecules with high precision, enabling specific tumor and virus cell killing. It powers CAR-T and BiTE therapies, showing potential to transform cancer and infectious disease treatment. www.nature.com/articles/s41...

nature.com

Targeting peptide antigens using a multiallelic MHC I-binding system - Nature Biotechnology

A protein platform rapidly develops peptide-focused major histocompatibility complex class I binders with high specificity.

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Possu Huang Lab @possuhuanglab.bsky.social · 17/12/2024

1/ In two back-to-back papers, we present our de novo TRACeR platform for targeting MHC-I and MHC-II antigens TRACeR for MHC-I: go.nature.com/4gcLzn5 TRACeR for MHC-II: go.nature.com/4gj5OQk

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