iiinova — where your digital self keeps evolving

Reposted by Michael Fischbach

Gabriel Victora @victora.bsky.social · 19/03/2025

Cool germinal center acrobatics from Juhee Pae et al, check it out! www.nature.com/articles/s41...

nature.com

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Tami Lieberman @contaminatedsci.bsky.social · 26/12/2024

This pair of papers demonstrating strong and systemic immune responses to skin commensals applied topically to unbroken skin, including induction of B cells for vaccination. www.nature.com/articles/s41... www.nature.com/articles/s41...

nature.com

Skin autonomous antibody production regulates host-microbiota interactions - Nature

Nature - Skin autonomous antibody production regulates host-microbiota interactions

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Dmitri Petrov @petrovadmitri.bsky.social · 26/12/2024

These are my favorites too! 🤯

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Christopher Barnes @cobarnes27.bsky.social · 24/12/2024

What an amazing story that was such a blast to collaborate on with @mfgrp.bsky.social lab!!! Phenomenal work led by @djenetbousbaine.bsky.social and all co-authors!! Unroll this thread and be amazed 🤯👇🏾

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ImmunoSketch @actuallypublished.bsky.social · 21/12/2024

Scientists turned a harmless skin bacterium into a powerful vaccine delivery tool, boosting immunity in the lungs and nose. @mfgrp.bsky.social @djenetbousbaine.bsky.social @nature.com t.co/xXXCJx5VYm #ImmunoSky 🧪

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Itai Yanai @itaiyanai.bsky.social · 20/12/2024

A typical project for an incoming graduate student might involve 1–2 weeks of planning and 2–5 years of execution, [yet] the problem you choose will influence the impact of your work just as much as the quality of your execution. @mfgrp.bsky.social open.spotify.com/episode/6KMh...

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Taia Wang Laboratory @wanglaboratory.bsky.social · 13/12/2024

Beautiful work with exciting implications for topical vaccination by @mfgrp.bsky.social ✨ Give this a read 👇

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Stanford Department of Bioengineering @bioe-stanford.bsky.social · 13/12/2024

Vaccines, but make it skincare!🧴🧬 Congratulations to Stanford BioE Professor Michael Fischbach @mfgrp.bsky.social & @djenetbousbaine.bsky.social for engineering a skin bacterium that could lead to needle-free vaccines.

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Djenet Bousbaine @djenetbousbaine.bsky.social · 12/12/2024

Check out our last pub. from @mfgrp.bsky.social al lab! We discovered that skin commensal microbes induce systemic and local B cell responses upon colonization and took advantage of this knowledge to create topical vaccines using engineered skin microbes. Please read the thread for details.

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Marshall Burke @marshallburke.bsky.social · 12/12/2024

Your hand lotion is now also a vaccine. Hot damn

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Christina (Chris) Tobin Kahrstrom @microchris.bsky.social · 12/12/2024

Illuminating thread by author ‪@mfgrp.bsky.social bsky.app/profile/mfgr...

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Andreas Peschel @andreaspeschel.bsky.social · 12/12/2024

Brilliant work congrats to the authors!

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Tim Stearns @stearnslab.bsky.social · 11/12/2024

Awesome thread from @mfgrp.bsky.social about what might be the most amazing result you'll hear about in 2024: antigens stuck on the surface of the skin bacterium S. epidermidis generate a strong immune response in mouse.

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Scott_Boyd_Lab_Stanford @scottboydlab.bsky.social · 12/12/2024

A remarkable story from @mfgrp.bsky.social and colleagues: immunization via skin S. epidermidis generates systemic and mucosal antibody responses.

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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 11/12/2024

And in a Nature publication double-header, @mfgrp.bsky.social @stanford-chemh.bsky.social collaborates with Yasmine Belkaid and workers in this study reporting on local immune response including antibody generation in response to skin commensals: www.nature.com/articles/s41...

nature.com

Skin autonomous antibody production regulates host-microbiota interactions - Nature

Nature - Skin autonomous antibody production regulates host-microbiota interactions

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Zamin Iqbal @zaminiqbal.bsky.social · 11/12/2024

This is the most amazing thread since they did a similar thing to cure a cancer

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Leyla Asadi, MD PhD @leylaaa.bsky.social · 11/12/2024

Wonder. Awe. Excitement. Very cool thread on a very cool finding. #IDSky

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Shai Bel (The Mucus Man) @mucusman.bsky.social · 11/12/2024

Holy shit this is amazing!!! 🤯

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Conor McClune @cmcclune.bsky.social · 11/12/2024

discovery that a skin microbe can, without inflammation, induce a systemic B-cell response... and then engineering that microbe into a potent vaccine platform that can be applied as a topical cream. amazing work from @djenetbousbaine.bsky.social and @mfgrp.bsky.social! www.nature.com/articles/s41...

nature.com

Discovery and engineering of the antibody response to a prominent skin commensal - Nature

Nature - Discovery and engineering of the antibody response to a prominent skin commensal

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Sorek Lab @soreklab.bsky.social · 11/12/2024

An amazing discovery, and a very informative and engaging thread. Could develop into a transformative new mode for efficient vaccination

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Carolyn King @immunologyking.bsky.social · 11/12/2024

one to savor over the holidays. also so cool to see how the directions of the work between @mfgrp.bsky.social and Belkaid labs diverged.

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Leif Erik Sander 🇪🇺🇺🇦 @sanderlab.bsky.social · 11/12/2024

Brilliant 🧵on a fascinating study demonstrating potent systemic and mucosal antibody responses to the common skin commensal Staph. epidermidis. Engineered S. epi expressing or displaying unrelated antigens elicited protective immunity,suggesting it could serve as topical vaccines. 💉

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Damian Maseda @dmaseda.bsky.social · 11/12/2024

Co-opting a skin commensal to design new vaccines! An amazingly creative and thoughtful new approach that integrates our knowledge of immune system responses. #ImmunoSky

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Reposted by Michael Fischbach

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 11/12/2024

Check out this bombshell publication by Michael Fischbach @mfgrp.bsky.social and coworkers @stanford-chemh.bsky.social @stanfordmedicine.bsky.social, imagine a cancer immune therapy/vaccine where treatment begins and ends with a painless topical skin treatment! 🤯 www.nature.com/articles/s41...

nature.com

Discovery and engineering of the antibody response to a prominent skin commensal - Nature

Nature - Discovery and engineering of the antibody response to a prominent skin commensal

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Michael Fischbach @mfgrp.bsky.social · 11/12/2024

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

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Itai Yanai @itaiyanai.bsky.social · 26/11/2024

When Jerry Seinfeld is refining a joke, he works very hard to figure out what is the actual core funny part, so he knows what he can strip away. Same with your idea: you have to figure out what is its essence, to know what is the simplest form of it to work on. -Michael Fischbach @mfgrp.bsky.social

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Itai Yanai @itaiyanai.bsky.social · 25/11/2024

The goal is not to have a zero risk project; those are generally not worth working on. People with a good relationship with risk are definitely not avoiding it. They are super honest about it and they basically make it their goal to slowly chip away at it. nightscience.buzzsprout.com/1744020/epis...

nightscience.buzzsprout.com

66 | Michael Fischbach and the scientific decision tree - Night Science

In this episode, Stanford professor Michael Fischbach discusses insights from his course on how to choose meaningful research problems. Highlights include:- Invest time in problem selection: Spend mor...

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Itai Yanai @itaiyanai.bsky.social · 17/11/2024

Too often we spend only two weeks choosing a problem and then many years trying solving it, but this limits our potential impact. A must read for PhD students: Problem choice and decision trees in science and engineering. pubmed.ncbi.nlm.nih.gov/38608651/

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