Extrinsic factors that support CD8+ T cell responses during chronic viral infection are incompletely defined. Gago da Graça et al. identify a crucial role for B cells in triggering type I interferon production, thereby promoting T cell effector formation in response to high antigen exposure, as seen in chronic infection.

Advances in technology continue to refine our understanding of CD8 T cell memory, with major implications for next-generation vaccines and therapies.

Here the authors identify an abundance of a tissue-resident memory-like T cell population in the breasts of women who have given birth. These cells can contribute to tumor control and may thereby prov...

B cells are highly abundant lymphocytes and central players in humoral immunity. Although T cells are well known to support humoral responses, how B c…

Exhaustion is a functional state that hampers anti-cancer and antiviral CD8 T cell activity, and is preceded by a stem-like state, maintained by the transcription factor TCF1. Here authors develop mou...

The authors show how Vγ1+ γδ T cells produce IL-4 to drive early CD8+ T cell and dendritic cell responses to malaria infection in mice.

The gut microbiome impacts immunity at various levels, including response to immunotherapy. Bachem et al. find that metabolic pathways shared across different microbiota constituents, including SCFA synthesis, modulate stem-like tumor-specific CD127+CD8+ T cells in the tumor-draining lymph node and impact control of melanoma.

Costings commissioned by independent MP Monique Ryan reveal the government could double how much funding it gives to innovative health research each year.

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US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.

ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer.

CD8+ T cell exhaustion is defined by a unique transcriptional and epigenetic profile that is important to understand for the generation of immunotherapies to treat cancer. Research now shows how this ...

Nature - Precursors of exhausted T cells are preemptively formed in acute infection

Nature - Precursors of exhausted T cells are preemptively formed in acute infection