Scientists must push back against the threat of rising white nationalism and the dangerous and pseudoscientific ideas of eugenics.

Darwinian evolution of immunoglobulin genes within germinal centers (GCs) underlies the progressive increase in antibody affinity following antigen ex…

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Factoring out nucleotide-level mutation biases from antibody language models dramatically improves prediction of functional mutation effects while reducing computational cost by orders of magnitude.

STANFORD, CA—Calling it a “pretty slow one” as far as natural selection and genetic drift were concerned, biologists from Stanford University confirmed Tuesday that not much evolution happened today. ...

An interview with Tasuku Honjo

Antibodies generated by prior immune responses regulate B cell responses upon recall immunization. Barbulescu et al. examine whether antibodies produced by an ongoing immune response influence the out...

Join us at the Keystone Symposia on B Cell and Antibody Responses, February 2027, in London, with field leaders!

Researchers are striving to understand the impact a phenomenon known as original antigenic sin has on immunity to the virus.

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Serum antibodies from prior immune responses regulate B cell activation and germinal center (GC) access upon recall immunization. However, how antibodies produced by an ongoing immune response influen...

Join us at the Keystone Symposia on B Cells and Plasma Cells: Fundamental and Translational Biology, March 2026, in Keystone, with field leaders!

For their discovery of the two distinct classes of lymphocytes, B and T cells – a monumental achievement that provided the organizing principle of the adaptive immune system and launched the course of...

B cells and the antibodies they produce are vital to health and survival, motivating research on the details of the mutational and evolutionary processes in the germinal centers (GC) from which mature...

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