AbstractIntroduction. Cell metabolism plays an important role in immune effector responses and through responding to metabolic signals, immune cells can ad

Abstract. Tissue-resident memory (TRM) T cells play an important role in protection against respiratory infection but whether this memory is maintained by

AbstractBackground. Innate lymphoid cells (ILCs) are prominent in the human uterine mucosa and play physiological roles in pregnancy. ILC3 are the second-m

In this article for the Highlights of 2024 series, we review the latest advances in the biology of the germinal center response. These discoveries provide key insights into germinal center function a...

This study examines how Notch signaling conditions the genome landscape within activated CD8+ T cells in such a way to alter the binding pattern of transcription factors such as Gata3. This Notch dep...

Abstract. Manipulating CD28 co-stimulation is a key element of anti-tumour immune responses and treating autoimmune diseases. CD28 can reduce the T cell ac

The Sensory Science exhibition, held during March 2024, was a collaborative effort between researchers and artists, aimed to promote the importance of inclusive and diverse scientific engagement for ....

Amy Wilson, a Research Advisor for the Ovarian Cancer Research Foundation (OCRF) and an Honorary Research Associate at the Hudson Institute of Medical Research, began her career as a postdoctoral res....

Bone marrow ablation and reconstitution are commonly used procedures in research that are often associated with significant suffering for the animals involved, classified as ‘severe’, Category E or C...

AbstractIntroduction. Concerns regarding the translational value of preclinical mouse models have been addressed by introducing various approaches of ‘natu

In this manuscript for the “Highlights of 2024” series, this is me trying to summarize recent discoveries regarding the emerging regulatory and effector roles of γδ T cells during sepsis, both in hum....

In this article, we discuss the conceptualization, formation and management of our workplace Parents Group. We honestly reflect on both our successes and challenges. Graphic from Vivienne Samson (age....

This article highlights the work of our trainee-led organization, Immunologists for Gender Equity (IgEquity), which addresses gender inequities in Immunology through initiatives focused on community ....

AbstractIntroduction. Obesity is a worldwide epidemic, with over 1 billion people worldwide living with obesity. It is associated with an increased risk of

In this article, we identify self-reactive peripheral blood B cells in Sjögren's disease through a single-cell culture system. We find 2- to 10-fold increased frequencies of self-reactive B cells dur...

In this study, we investigated multiple cytokine combinations to boost natural killer (NK) cell proliferation as well as effector functions of proliferated NK cells against hepatocellular carcinoma a...

This manuscript, part of the Special Series “Focus on South American immunology”, provides a personal reflection on the challenges and opportunities I have encountered during my journey as an immunol...

In this study, we investigated the longitudinal dynamics and clonal expansion of circulating γδ T cells in four patients receiving anti-CD19 CAR-T cell therapy. Using single cell multi-omics analysis....

AbstractIntroduction. Programmed death-1 (PD-1) is a negative regulator of immune responses. Upon deletion of PD-1 in mice, symptoms of autoimmunity develo

This review discusses the dysregulation of several members of chemokines that have been reported in the CNS, cerebrospinal fluid and peripheral blood of patients with neurodegenerative disorders. Upo....

PhD training is incredibly versatile, with the possibility of leading to a myriad of downstream careers. However, it is often only in retrospect that the options and optimal strategies behind your ca...

Positive research cultures provide the environment for scientists to explore ideas, grow as individuals, develop team science and create a positive impact on those around them. Here we focus on key a...

<em>Immunology & Cell Biology</em>  is the flagship journal of the ASI, focusing on the general functioning of the immune system, with particular emphasis on its cell biology.

Raaphorst, Lougheed et al. present a technique that allows simultaneously measuring ongoing and past T-cell proliferation by flow cytometry by combining the EdU incorporation assay (short-term T-cell....

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<em>Immunology & Cell Biology</em>  is the flagship journal of the ASI, focusing on the general functioning of the immune system, with particular emphasis on its cell biology.

This study contributes to the understanding of the immune profile of patients with bladder cancer, highlighting specific alterations in peripheral blood immune subsets and immune checkpoint marker ex...

AbstractBackground. Immunometabolism is a crucial determinant of immune cell function, influencing cellular activation and differentiation through metaboli

In this Future Challenges article, we discuss strategies that the La Trobe Green Labs team has implemented, leading the change in sustainable lab practices in Australia. By focusing on education, ope....

In this article, we discuss a recently published study by Gopee et al., who have unveiled a surprising role for macrophages in human prenatal skin development, extending far beyond their traditional ...

In this study, we investigated the impact of genetic variation on the germinal center response. Using a panel of genetically divergent strains, we uncover an important impact of genetics on the numbe...

We here describe how we set up the virtual ‘γδ T Cell Club’, a monthly webinar series that aims to bring the γδ field closer together, and present our musings about what we have learned from this exp...

The increased permeability of the intestines is implicated in the pathogenesis of many diseases that helminth infection is proposed to protect their host against developing. In this study, we examine....

This study demonstrates that three secreted immune evasion factors from the staphylococcal superantigen-like (SSL) protein family—SSL3, 7 and 11—can be successfully fused into a polyprotein. Mice imm...