Alice Ting @aliceyting.bsky.social · 18/03/2026We are recruiting! If you are passionate about technology development, protein engineering, computational design, directed evolution, chemical biology - please reach out! (The setting is pretty nice too…) 13017
Alice Ting @aliceyting.bsky.social · 18/03/2026Today we report single-cell APEX-seq (scAPEX-seq)—a method for unbiased mapping of subcellular transcriptomes at single-cell resolution. It reveals cell states invisible to standard scRNA-seq and identifies regulators of CAR T function that improve solid tumor killing. tinyurl.com/32pf6b8p 16622
Alice Ting @aliceyting.bsky.social · 08/01/2026Video introduction to our new “Conformational Biasing” method for computational design of mutations that bias proteins towards desired conformational states CB part starts at 14:55 Thanks to Peter Cavanagh and Andrew Xue – amazing graduate students who co-led this workyoutube.comAlice Ting Rosettacon keynote 2025YouTube video by Alice Ting 1268
Alice Ting @aliceyting.bsky.social · 08/01/2026Can we design mutations that bias proteins towards desired conformational states? Today in @science.org, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify conformation-biasing mutations.science.orgComputational design of conformation-biasing mutations to alter protein functionsConformational biasing (CB) is a rapid and streamlined computational method that uses contrastive scoring by inverse folding models to predict protein variants biased toward desired conformational sta... 111737
Alice Ting @aliceyting.bsky.social · 10/12/2025New work describes our efforts to achieve CRISPR editing of the mitochondrial genome. www.biorxiv.org/lookup/conte...biorxiv.orgTowards CRISPR-based editing of the mitochondrial genome in yeastMitochondria, which evolved from symbiotic bacteria, possess their own genomes (mtDNA) and support independent transcription and translation within the organelle. Given the essential role of mtDNA in ... 14010
Reposted by Alice TingJingchuan Luo @jingchuanluo.bsky.social · 27/08/2025I'm thrilled to share our work from @weissmanlab.bsky.social (www.sciencedirect.com/science/arti...). We developed LOCL-TL, an optogenetic approach for monitoring localized translation in mammalian cells. LOCL-TL revealed two distinct strategies for mitochondrially localized translation. 1196
Alice Ting @aliceyting.bsky.social · 27/08/2025Proximity-specific ribosome profiling using LOV-BirA reveals two distinct strategies for mitochondrially-localized translation: one for long coding sequences and one for short. It was a pleasure to contribute to this beautiful work from Jonathan Weissman @weissmanlab.bsky.social and Jingchuan Luo 1327
Alice Ting @aliceyting.bsky.social · 27/08/2025LOV-BirA, light regulated biotin ligase, engineered by Song-Yi Lee www.sciencedirect.com/science/arti...sciencedirect.comProximity-specific ribosome profiling reveals the logic of localized mitochondrial translationLocalized translation broadly enables spatiotemporal control of gene expression. Here, we present LOV-domain-controlled ligase for translation localiz… 082
Reposted by Alice TingNature Chemical Biology @natchembio.nature.com · 01/08/2025A new paper from @aliceyting.bsky.social reports on LaccID, an engineered laccase, that enables hydrogen peroxide-free proximity labeling and electron microscopy of cell surfaces www.nature.com/articles/s41...nature.comDirected evolution of LaccID for cell surface proximity labeling and electron microscopy - Nature Chemical BiologyLaccID, an engineered laccase, enables hydrogen-peroxide-free proximity labeling and electron microscopy (EM) in mammalian cells. Notably, LaccID is selectively active at the cell surface, enabling th... 0136
Alice Ting @aliceyting.bsky.social · 18/08/2025Can a single researcher test over half a million chemical reactions in <3 days? Yes, using Jeff Martell’s new DNA-encoded combinatorial screening platform. Check out his lab’s exciting new preprint 👇 0101
Alice Ting @aliceyting.bsky.social · 26/03/2025We are hiring a new lab manager! Our wonderful lab manager Albert is headed off to grad school and we are looking to fill his position this summer. This is a great opportunity for a new graduate to spend a couple years immersed in research before applying to PhD or MD programs. 50% of the job is... 1178
Alice Ting @aliceyting.bsky.social · 26/02/2025Today we report the directed evolution of HUH into rHUH, a sequence-specific covalent protein tag for RNA labeling. rHUH was hard to engineer: the initial HUH template had no RNA activity, so we started with RNA-DNA hybrids. 30 rounds of selection on the yeast surface were required, and 7 cycles of 310531
Alice Ting @aliceyting.bsky.social · 30/01/2025Tetanus on demand! (not for bioweapons, but for neuroscience research) Tetanus toxin induces paralysis by using a protease to cleave VAMP2, a protein required for synaptic vesicle fusion and neurotransmitter release. To harness this toxicity and use it as a beneficial tool for neuroscience, 25517
Alice Ting @aliceyting.bsky.social · 09/01/2025Are you a Japanese student interested in a postdoctoral fellowship in the US? The Chan Zuckerberg Initiative has an exciting new fully-funded Global Science Scholars program to pair students who have received their undergraduate or doctoral degrees in Japan with US bioengineering and biomedical...czbiohub.orgGlobal Science Scholars Postdoctoral Fellowship Program SS-FApply for the new international postdoctoral fellowship program from the CZ Biohub Network and Stellar Science Foundation. 275
Alice Ting @aliceyting.bsky.social · 04/12/2024Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation.. 33434138
