Random noise can break symmetries and enhance the stability of collective behaviors

Cell-state diversity drives tissue adaptability, repair, and disease resilience, but capturing this complexity is a challenge. Current approaches rely on transcriptional profiling and overlook organel...

Nature - Chronic reactivation of distinct herpesviruses and anelloviruses occur during acute and long COVID-19, and track with disease severity, inflammation and outcomes, revealing immune...

Reactivation of typically harmless anelloviruses, in particular, seems to be linked with developing long COVID, study finds.

PD-1+ T follicular helper-like cells drive B cell-associated pathology in multiple sclerosis. Programmable PD-1-targeting CAR T cells selectively eliminate these pathogenic CD4 T cells while deliverin...

Complement component 1q (C1q), the initiator of the classical complement cascade, mediates synaptic elimination in development and disease, yet the triggers for its deposition on synapses remain uncle...

Large language models can be used to estimate the results of social science experiments about as accurately as a group of human forecasters—even for experiments published after the...

Research from UCL suggests visiting art galleries or museums, singing and painting can help improve health outcomes

The peer-reviewed journal article, perhaps the single most important device behind the expansion of scientific knowledge in the last century, is an extraordinarily expensive way to share novelty: e…

Flood of proposals to European Research Council—perhaps unleashed by AI—means unsuccessful applicants must wait longer to reapply

The EMF-inducible gene switch (Ei) platform provides precise spatiotemporal control of gene expression through Cyb5b-mediated calcium oscillations. This system enables Ei-OSK-driven in vivo rejuvenati...

Nature - Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity

Biases in molecular evolution can significantly influence evolutionary trajectories. They have been described in a variety of contexts such as development and mutation, but not for acquiring new funct...

Paracrine signalling between tuft cells and enterochromaffin cells is a key mode of immune–sensory and gut–brain communication, and accounts for the pattern of gastrointestinal symptoms that occu...

Colonic stem cells retain a memory of inflammation following disease resolution and there is a mechanistic link between chronic inflammation and malignancy, suggesting potential strategies to mitigate...

ALT: two men are sitting next to each other on a subway and talking .

Understanding how DNA replication forks stall and restart and how the DNA replication checkpoint prevents irreversible fork collapse in molecular deta…

A study investigating the emergence of squamous tumours in the upper gastrointestinal tract of the mouse shows that an initial tumour stress response triggers fibroblasts to remodel the underlyin...

A vacant block near the center of the Gold Coast’s once glitzy tourist strip is set to become the site of Australia’s tallest tower – and the first with the surname Trump emblazoned across the top.

LARP6 is an EMT-associated RNA-binding protein with diverse RNA targets. Here, the authors show that the N-terminal disordered region of LARP6 promotes RNA-binding selectivity by modulating the adjace...

Stress responses enable cells to detect, adapt to, and survive challenges. The benefit of these signaling pathways depends on their reversibility. The integrated stress response (ISR) is elicited by p...

Cancer is a common cause of morbidity and mortality in domestic cats. Because the mutational landscape of domestic cat tumors remains uncharacterized, we performed targeted sequencing of 493 feline tu...