iiinova — where your digital self keeps evolving

Aubry K. Miller @aubrykmiller.bsky.social · 15/09/2026

Really looking forward to speaking at the PROXIDRUGS Lecture Series this Thursday. The seminar will be broadcast online, so please join us at 16:00 CEST. Thanks @hauschlab.bsky.social for the invitation!

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Stephan Hacker @stephanhacker2.bsky.social · 14/09/2026

Are you interested in the newest and most exciting research in Chemical Biology? The Advances in Chemical Biology on January 26th and 27th, 2027, in Frankfurt, Germany, might just be the event for you! Check out the details here: www.dechema.de/en/ChemBio2027 (1/4)

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Aubry K. Miller @aubrykmiller.bsky.social · 17/07/2026

Whenever Claude or ChatGPT look up some skill or connect to an API, I think of Neo saying "I know KungFu" in The Matrix.

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Aubry K. Miller @aubrykmiller.bsky.social · 21/04/2026

Not quite an Earthset, but I’ll take it. #AACR

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Aubry K. Miller @aubrykmiller.bsky.social · 16/02/2026

I'm very excited to share our newest preprint, where we show that long, linear bifunctional molecules like PROTACs can bind within the narrow ubiquinone-binding tunnel of mitochondrial complex I, leading to off-target mitotoxicity. www.biorxiv.org/cgi/content/... (1/4)

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Aubry K. Miller @aubrykmiller.bsky.social · 05/02/2026

What are you waiting for? Go work with Elena!

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Reposted by Aubry K. Miller

Sylvia Erhardt @erhardtlab.bsky.social · 03/02/2026

🧪 My lab has an opening for a postdoc position soon! Please share/get in touch!

Ad for a postdoc position in centromere biology with colorful chromosomes and centromeres made out of FIMO.

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Reposted by Aubry K. Miller

Mike Lacy @mlacyphd.bsky.social · 29/07/2025

💡 Always a good time to be reminded: "if you fuse your protein of interest to GFP or EGFP to study the protein's behavior ... you are using a tag with a serious drawback." Same goes for anything that doesn't have 'm' in its name (looking at you, dTomato and StayGold)

blog.addgene.org

When is a Monomer not a Monomer? The Top Three Ways Your Favorite Fluorescent Protein Oligomerizes in Cells

Many commonly used fluorescent proteins form dimers producing artifacts in a variety of experimental settings. Learn how to avoid these artifacts.

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Aubry K. Miller @aubrykmiller.bsky.social · 26/05/2025

I can't believe I missed @dereklowe.bsky.social commenting on our @natchem.nature.com a month ago at "In the Pipeline". I've dreamt for many years that Derek would choose to highlight work coming out of the lab. That feels like a real stamp of approval. Thanks, Derek! www.science.org/content/blog...

science.org

Proton Pump Inhibitors Do More Than You Think

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Reposted by Aubry K. Miller

Lennart Hilbert @lennarthilbert.bsky.social · 10/04/2025

Our Synthetic Genomics Center "SynGen" is looking for a coordinator, located at @kit.edu Karlsruhe, but coordinating also the U Heidelberg and U Mainz sites. We are hoping to fill this vacancy ASAP. For further info, please visit: www.syn-gen.de/en www.pse.kit.edu/english/karr... Please share 🙏

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Aubry K. Miller @aubrykmiller.bsky.social · 24/02/2025

The most recent roadmap problem from our Synthesis Club is up on our shiny new website. This quiz highlights the synthesis of clionastatin B from the group of Jinghuan Gui. www.dkfz.de/en/cancer-dr...

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Aubry K. Miller @aubrykmiller.bsky.social · 20/02/2025

Check out our paper on proton pump inhibitor activation (PPI) in cells in Nature Chemistry. Congrats to first author Teresa Marker who started this project in my group and finished it with Tobias Dick (@redoxdkfz.bsky.social). More collabs between our groups to come! doi.org/10.1038/s415...

nature.com

Site-specific activation of the proton pump inhibitor rabeprazole by tetrathiolate zinc centres - Nature Chemistry

Proton pump inhibitors (PPIs) are prodrugs that are activated by protonation in the highly acidic environment of the stomach lining. Now, coordination of PPIs to protein-bound zinc ions is revealed as...

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Aubry K. Miller @aubrykmiller.bsky.social · 17/02/2025

Great opportunity to work with an excellent young group leader.

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Reposted by Aubry K. Miller

Michael Hothorn @structplantbio.bsky.social · 23/01/2025

From Dorothea Fiedler's lab: Protein polyphosphorylation as a new post-translational modification www.biorxiv.org/content/10.1...

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Aubry K. Miller @aubrykmiller.bsky.social · 15/01/2025

This week’s Synthesis Club quiz featured a total synthesis that one of our recent Master’s students contributed to as an intern in the US. Anyone recognize this beauty?

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Aubry K. Miller @aubrykmiller.bsky.social · 13/01/2025

I had no idea Rodney Mullen, the Godfather of skateboarding, had studied Chemical Engineering. Thanks, Rodney, for putting two of my favorite things together on one slide. youtu.be/2c3aXbwM8L0?...

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Aubry K. Miller @aubrykmiller.bsky.social · 19/11/2024

Starting what will hopefully become a regular feature here…our disconnection analysis of a natural product total synthesis from our biweekly Synthesis Club meetings. Anyone recognize this recent beauty? #chemsky

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Aubry K. Miller @aubrykmiller.bsky.social · 13/05/2024

Congratulations to former PhD student Raphael Steimbach for winning the EFMC-Young Scientists Network PhD prize (www.efmc.info/ysn-phd-prize). Come see his lecture in Rome at #EFMC-ISMC in September. Congratulations Raphael!

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