Traditional precious metal catalysis benefits from well-characterized inner-sphere elementary steps in which a single complex binds and unites substrates at the metal center. By contrast, base metal c...

Low-energy photons from deep-red (DR) to near-infrared (NIR) light offer unique opportunities for sustainable photochemical synthesis but suffer from intrinsically limited reactivity. This Review sum...

The Trump administration’s decision to shut down the U.S. Agency for International Development (USAID) has resulted in hundreds of thousands of deaths from infectious diseases and malnutrition, accord...

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Molecular glue degraders have consistently been discovered retrospectively, despite their increasing importance. Herein, a high-throughput approach is described that modifies existing ligands into mol...

Covalent inhibitors are powerful entities in drug discovery. Now the amino acid selectivity and reactivity of a diverse electrophile library have been assessed proteome-wide using an unbiased workflow...

Hydrogen-mediated reductive cross-couplings of aryl iodides with activated aryl and heteroaryl bromides are described, along with related homocouplings (Ullmann reactions) and vinylic reductive couplings that occur with cine-substitution. To corroborate key events in the catalytic cycle, Pd-to-Pd transmetalation and cross-selective reductive elimination, dianionic diarylpalladate complexes [Pd(Aryl)(μ-Br)Br]2[NPr4]2 bearing p-fluorophenyl, p-methoxyphenyl and p-nitrophenyl moieties were prepared. Stoichiometric reactions of these complexes in the presence of iodide demonstrate that Pd-to-Pd transmetalation by way of monomeric arylpalladates occurs at a greater rate than reductive elimination and that cross-selective C–C reductive elimination is favored for electronically distinct aryl partners. Hydrogen-mediated reductive cross-coupling of aryl iodides with α-bromostyrene occurs with cine-substitution (as observed in related formate-mediated processes), consistent with carbopalladation of α-bromostyrene by monomeric arylpalladates Pd(Aryl)I2[NBu4] that arise upon dissociation of [Pd(Aryl)(μ-I)I]2[NBu4]2.

Targeted protein degradation (TPD) is an emergent therapeutic strategy with the potential to circumvent challenges associated with targets unamenable to conventional pharmacological inhibition. Among ...

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A journey through the front lines of global poverty shows that when the world’s richest men slash aid for the world’s poorest children, the result is sickness, starvation and death.

SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.

Biocompatible covalent reactive groups (CRGs) play pivotal roles in several areas of chemical biology and the life sciences, including targeted covalent inhibitor design and preparation of advanced biologic drugs, such as antibody–drug conjugates. In this study, we present the discovery that the small, chlorinated

Fraud in research needs to end.

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Challenge.Gov is the official GSA government website supporting prize challenges and prize competitions that are sponsored by the US federal government. Here federal agencies provide prize awards to ...

This Special Issue will highlight the significant research activities at Primarily Undergraduate Institutions (PUIs) in the United States and their unique focus on fostering student engagement in STEM...

Many terpene glycosides exhibit contrasteric patterns of 1,2-diol glycosylation in which the more hindered alcohol bears a sugar; protection of the less hindered alcohol only increases steric repulsion. Here, we report a method for contrasteric glycosylation using a new sugar-linker that forms a cleavable, 10-membered ring with high efficiency, leading to syntheses of cotylenin E, J, and ISIR-050. Linker selection was aided by DFT calculations of side reactions and stereoselectivity, as well as conformational analyses using autoDFT, a Python script that converts SMILES strings to DFT-optimized conformational ensembles.

Much natural-product-based drug discovery has depended on the practices of Indigenous Peoples, who have sometimes invested centuries of care into the cultivation and use of plant or fungal matter. How...