Other researchers question whether autonomous AI scientists are possible or even desirable.

This study provides a single-cell RNA-sequencing atlas of 77 healthy and chronic liver disease livers and identifies a subpopulation of pro-inflammatory scar-associated macrophages enriched for OLR1 e...

Shi et al. use a spatiotemporal framework to profile alloreactive T cells in humans undergoing hematopoietic cell transplantation and demonstrate how severe graft‑versus‑host disease is driven by tiss...

Peptides are presented to T Cell receptors (TCR) in the context of human leukocyte antigen (HLA) MHC molecules and the prediction of these peptide sequences are important for vaccines and cancer thera...

Saturn’s icy moon Enceladus features chemical signatures consistent with an alkaline soda ocean with H2 production via hydrothermal water-rock reactions. Chemolithoautotrophic methanogenesis is thermo...

Incendiamoeba cascadensis may survive in volcanic lakes thanks to a static blanket that shields its proteins from the heat

TRAM is a regulator of myddosome assembly through dissociating MyD88 from the TLR–TIRAP complex to enable myddosome maturation and durable downstream signal transduction.

In a wide-ranging interview, the New York congresswoman offered her most detailed insight yet into how she is thinking about a possible presidential run.

A.I. is already a powerful tool for scientific discovery. Now, some biomedical researchers are teaching it to do even more.

Human induced GC-like B (iGCB) cells are generated in vitro from circulating naive or marginal zone cells.

Tang and colleagues identify a distal IRF4 chromatin regulatory region that governs human Treg cell stability.

ALT: Heartstopper S2

In early results from our new life sciences research lab, Claude agents found an enzyme system whose function is still unknown.

When Dr Richard Jacoby arrived at Monash University in August as part of EMBL’s ARISE fellowship program, he hoped to deepen his technical expertise and learn more about Australia’s research infrastru...

Cyclostratigraphic analysis of a ~1.2 billion-year-old rhythmically bedded mudstone formation in the Grand Canyon shows that the frequency and amplitude of Milanković cycles were markedly different th...

Tissue-resident memory (TRM) CD8+ T cells in the tumor microenvironment are relevant for anti-tumor immunity and immune checkpoint blockade response. Here, the authors conditionally ablate type 1 and ...

Chimaeric antigen receptors (CAR) approved for the treatment of multiple myeloma have been reported to have different therapeutic efficacies. In this study, the authors demonstrate that this differenc...

T cell‐based immunotherapies have achieved remarkable success in hematological malignancies but remain limited in solid tumors. Natural killer (NK) cells offer a compelling complementary approach, giv...

Daniel Blumstein recently sat in a Colorado meadow waiting for yellow-bellied marmots to appear, as the ecologist and evolutionary biologist had done many times before, the New York Times reported. Bu...

The 2026 call has attracted considerable interest from the research community with 21,627 applications submitted.

Cells undergo membrane remodeling in response to the environment to perform specific functions. Now, a cytometry-based method with immune cell biomarker analysis captures variations in plasma membrane...

Achieving programmable gene regulation remains a challenge for engineering T cells. Here the authors characterize a library of synthetic promoters, responsive to seven endogenous T cell transcription ...

CFM enables tunable cell confinement for measuring traction forces exerted by single cells and cell aggregates in tissue-mimicking microenvironments.

Halting deforestation and promoting restoration are at the core of strategies to confront the biodiversity and climate crises in tropical forests. Avoiding forest disturbances is also critically impor...

An mRNA-lipid nanoparticle-encoded CD19×CD3 T cell engager depletes B cells with attenuated cytokine release in preclinical models. In three patients with treatment-refractory immune thrombocytopenia,...

Scientists have long dreamt of being able to track and analyse each step in the assembly of a virus’s protein shell. An ingenious experiment shows how this can be done.

Those in the medical profession say the HBO Max show about a US hospital emergency room is the most realistic medical drama yet.

A new chemistry-based super-resolution imaging framework is described, enabling 3D, laser-free, highly sensitive and ultralong-term imaging of live cells which overcomes the limitations in spatiotempo...

Agonistic antibodies initiate signalling by the receptors they target, mimicking the activities of native ligands. This Review discusses the clinical successes and failures of agonistic antibodies and...