🧬 Happy to see our paper finally out!
Here we show that a post-translational modification tunes Hsp70–J-domain protein interaction by unfolding of the J-domain. This either blocks Hsp70 engagement or leads to protein degradation. Check out how this phospho-switch rewires chaperone networks:
nature.com
A conserved tyrosine motif encodes a structural vulnerability controlling stability and activity across J-domain proteins - Communications Biology
NMR spectroscopy and functional assays define a conserved tyrosine motif outside the canonical J-domain core of J-domain proteins. The motif stabilizes the fold, and its phosphomimetic perturbation dr...
