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Ci Ji (CJ) Lim

@cijilim.bsky.social
1.3K followers 985 following 98 posts

Associate Professor @ UW-Madison Biochemistry. www.limlab.org Telomeres, Cryo-EM, Single-molecule Biophysics. Opinions are my own. 🇸🇬

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Reposted by Ci Ji (CJ) Lim
Adam Bentham @adamrbentham.bsky.social · 10h
🚨 Please share! 🚨 I'm recruiting a fully funded 4-year Gatsby Sainsbury PhD studentship at Durham! 🌱🤖 Designing plant immune receptors from scratch, combining AI protein design with structural biology and plant immunity. If you're interested please get in touch! benthamlab.org shorturl.at/U2PdV
benthamlab.org
Bentham Lab — Durham University
Bentham Lab, Centre for Programmable Biological Matter, Durham University. Structural biology and de novo protein design applied to host-pathogen interactions, plant immunity, and neglected tropical d...
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American Society for Cell Biology @ascbiology.bsky.social · 3h
NIH is considering changes to how grant review results are reported, including eliminating numerical overall impact scores. Comments are due Oct. 13. Learn more and make your voice heard: www.ascb.org/science-policy/nih-pro…
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Reposted by Ci Ji (CJ) Lim
UW–Madison Department of Biochemistry @uwbiochem.bsky.social · 7h
This month, the Department of Biochemistry welcomed Rae Brown to the team of instructional faculty, whose primary role is developing and teaching undergraduate biochemistry courses. Get to know more about Rae through their Q&A! biochem.wisc.edu/2026/09/23/n...
biochem.wisc.edu
New Instructional Faculty: Rae Brown
Get to know Rae Brown through their Q&A.
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Reposted by Ci Ji (CJ) Lim
Matthew Freeman @mjafreeman.bsky.social · 6h
Yet another opportunity @dunnschool.bsky.social! We are looking for an Associate Professor If you have exciting research plans, @dunnschool.bsky.social is a great place: excellent science (and lovely people, obvs) www.path.ox.ac.uk/vacancy/asso...
path.ox.ac.uk
Associate Professorship of Cancer Biology - Sir William Dunn School of Pathology in association with the Queen’s College. - Dunn School
We are seeking to appoint an Associate Professor working in the area of the cellular and/or molecular biology of cancer, to be based in Oxford University’s Sir William Dunn School of Pathology. The ro...
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NanoTag Biotechnologies @nanotag.bsky.social · 28/09/2026
✨🔬 Want to see our JF635b-conjugated #nanobodies in action? 📄 Check out the recent NanoLetters paper by Samrat Basak @samratb.bsky.social, Roman Tsukanov @romantsukanov.bsky.social, Felipe Opazo @opazo.bsky.social et al., doi.org/10.1021/acs....
doi.org
Self-Blinking Dye Restores Efficient Use of Nanobodies in Single-Molecule Localization Microscopy
Abstract. Direct stochastic optical reconstruction microscopy (dSTORM) relies on controlled fluorophore blinking to achieve nanometer-scale resolution, yet
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Reposted by Ci Ji (CJ) Lim
Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 25/09/2026
Can't wait for the semester's first RNA Maxigroup meeting next Tuesday! Sarah Loerch will present her work. Thanks to @rnasociety.bsky.social , @bmolchem.bsky.social , @uwbiochem.bsky.social , and the UW Madison CMB program for funding!
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Suckjoon Jun’s lab at UCSD @junlab.bsky.social · 28/09/2026
1/5 Do you use GFP to measure protein abundance? Be very careful. Our new bioRxiv preprint shows that, under translation inhibition, fluorescence can stop tracking how much reporter protein is actually there. Please share widely.
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Max Kozlov @maxkozlov.bsky.social · 25/09/2026
SCOOP: Top researchers at Columbia, Stanford, and others thought they were elected to elite scientific societies alongside Nobel laureates. The catch? The organizations are a sham. I spent the last month diving deep into a massive academic scam spanning continents, for @nature.com
nature.com
Exclusive: Sham scientific societies are misleading star researchers
A Nature investigation reveals a network of organizations that have been building their ranks through deceptive practices.
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Nature Biotechnology @natbiotech.nature.com · 25/09/2026
Photolabile oligonucleotides with topological light gradients enable spatially resolved single-cell transcriptomics and epigenomics - @ucsantabarbara.bsky.social www.nature.com/articles/s41...
nature.com
Photolabile oligonucleotides with topological light gradients enable spatially resolved single-cell transcriptomics and epigenomics - Nature Biotechnology
A photolabile oligonucleotide system enables spatially resolved single-cell measurements to show how the epigenome regulates gene expression.
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Reposted by Ci Ji (CJ) Lim
Rasmus Jensen @rasmusjensen.bsky.social · 25/09/2026
🎉 Out today in Cell: the paper I've been looking forward to sharing for a long time 🎉 We used cryo-ET to find a molecular machine nobody knew existed on the surface of a minimal bacterium, and worked out what it does. 🧵(1/7) #TeamTomo #cryoET
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cryoEM papers @cryoempapers.bsky.social · 25/09/2026
High-resolution cryoEM of nucleosomes in nuclear extracts of mammalian cells pubmed.ncbi.nlm.nih.gov/42782067/ #cryoEM
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cryoEM papers @cryoempapers.bsky.social · 25/09/2026
On-grid enrichment strategies in cryo-EM: affinity-functionalized supports for low-abundance and challenging targets pubmed.ncbi.nlm.nih.gov/42781870/ #cryoEM
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Julieta Rivosecchi @jurivosecchi.bsky.social · 24/09/2026
We explored the role of the telomeric RNA TERRA in cancer cells that transition from telomerase to ALT to maintain telomeres. We show that TERRA levels remain unchanged, but TERRA molecules relocate to telomeres and engage in R-loops. See thread ↓ link.springer.com/article/10.1...
link.springer.com
ALT induction by ASF1 depletion is associated with TERRA accumulation at telomeres and relies on R-loops - Cell Communication and Signaling
The mechanism of Alternative Lengthening of Telomeres (ALT) relies on homologous recombination processes taking place at telomeres within ALT-associated PML bodies, or APBs. ALT cells express high lev...
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Weill Institute for Cell & Molecular Biology @weillinstitute.bsky.social · 24/09/2026
Join @weillinstitute.bsky.social and Biomedical & Translational Sciences at Cornell University! We're seeking a scientist to turn fundamental cell & molecular biology insights into therapeutic discovery. Build a bold research program with opportunities to advance human and animal health. 🧬🔬
Scientist working at the bench in research lab.https://tinyurl.com/WICMB-BTS
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Reposted by Ci Ji (CJ) Lim
Vasilii Mikirtumov @vasiliimikirtumov.bsky.social · 24/09/2026
thrilled to share that my main phd project is finally out in @natcomms.nature.com we present high-resolution structures of RyR1 in native membranes across multiple functional states by both cryo-ET/StA #TeamTomo and SPA! paper: www.nature.com/articles/s41... and a thread below⬇️⬇️⬇️
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Nahel Belgherze @wxnb.bsky.social · 24/09/2026
Unbelievable footage from NOAA’s Hurricane Hunters inside the eye of Category 5 Hurricane Polo. Simply incredible.
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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 24/09/2026
AlphaFold Database is expanding into pandemic preparedness. Together with NVIDIA, DeepMind, EBI et al. we exhaustively predicted ~1.7 million homo- & heterodimers across 2,812 viral proteomes, resulting in 8,028 high-confidence predictions. 📄 research.nvidia.com/labs/dbr/ass... 🌐 alphafold.ebi.ac.uk
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David Solecki @so-lets-kilab70.bsky.social · 24/09/2026
Georgios Skiniotis and I are announce a unique St. Jude faculty search: a joint effort between the CoE for Structural Cell Biology an intellectual community advancing structural imaging & the Division of Neuronal Cell Biology. CryoET/vEM + neuron cell biology = 🚀 talent.stjude.org/careers/JobD...
talent.stjude.org
Faculty position, Neuronal Cell Biology and Cryo-ET/vEM
Department of Developmental NeurobiologyCenter of Excellence for Structural Cell Biology and Neuronal Cell Biology DivisionSt. Jude Children’s Research HospitalThe Center of Excellence for...
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Drug Monkey @drugmonkey.bsky.social · 24/09/2026
It's frustrating viewing to go through the new (type 1 and type 2 competing) awards by IC at grantwitness.org/nih/analyses... remember, the budget is under CR and has been the same 2004-2006. Some ICs are doing worse, some better year over year.
grantwitness.org
Agency Pulse: Grantmaking at NIH
An independent, up-to-date, grant-level record of federal science funding disruptions in the United States.
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Ci Ji (CJ) Lim @cijilim.bsky.social · 24/09/2026
Very cool!!!
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Reposted by Ci Ji (CJ) Lim
Doug Kojetin @dougkojetin.bsky.social · 23/09/2026
Apply today to be my colleague at Vanderbilt in the Department of Biochemistry! 
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Craig Kaplan @triggerloop.bsky.social · 23/09/2026
I guess I will be interested to read this preprint or paper
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Martin Pacesa @martinpacesa.bsky.social · 21/09/2026
ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/Bi...
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Ci Ji (CJ) Lim @cijilim.bsky.social · 22/09/2026
Congratulations to Yuan and his team!
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Reposted by Ci Ji (CJ) Lim
Séamus Holden 🔬🦠🧫 @seamusholden.bsky.social · 18/09/2026
Really impressing MINFLUX tracking of molecular motors www.nature.com/articles/s41... #bioimaging
nature.com
Characterizing dynamics of productive dynein stepping by MINFLUX - Nature Structural & Molecular Biology
Slivka et al. track dynein’s microtubule-binding domain with minimal fluorescence photon flux, revealing transient backward ‘dips’ before steps. These dips represent microtubule release upon ATP bindi...
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Sergey Ovchinnikov @sokrypton.org · 17/09/2026
Introducing highly experimental localfold.org Building on @martinsteinegger.bsky.social af2 webgpu port, @milot.bsky.social optimizations & jax ports of af3-like models by @marielle.bsky.social, Choonghwan Lee, Julia Buhmann. WARNING: runs directly on your 💻, may drain 🪫 & eat data📱 & overheat 🔥💻
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Jaap de Roode @jaapderoode.bsky.social · 15/09/2026
So excited to share that the Department of Biology @emoryuniversity.bsky.social is hiring an open-rank faculty member in the area of ecology. Happy to answer any questions. Please share! 🧪 apply.interfolio.com/191783
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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Reposted by Ci Ji (CJ) Lim
Claus Wilke @clauswilke.com · 15/09/2026
The Department of Integrative Biology at UT Austin has two open positions for assistant professors, one in evolutionary biology and one in mechanistic processes. Please share. Apply here: apply.interfolio.com/193270
Two Assistant Professor Positions in Evolutionary Biology and Mechanistic Processes

Description
The Department of Integrative Biology at The University of Texas at Austin seeks to fill two faculty positions in the areas of Evolutionary Biology and Mechanistic Processes, broadly defined. We are looking for candidates who are advancing (1) evolutionary biology or (2) the mechanistic understanding of organismal processes. These positions will be filled at the level of Assistant Professor.


Qualifications
Candidates should be using innovative approaches in evolutionary biology and/or the mechanistic understanding of whole-organism processes. Mechanistic processes include, but are not limited to, behavior, biomechanics, cognition, physiology, and development. The phylogenetic scope of the Evolutionary Biology position may include eukaryotes, prokaryotes, viruses, and the scale may include individual molecules to entire ecosystems and beyond. Candidates for either position may employ experimental, theoretical, or computational frameworks, or a combination thereof. Special consideration will be given to applicants with demonstrated potential for integrating across our target disciplines. 

We seek applicants with a strong record of high-quality research, publications, potential for extramural funding, and a commitment to excellence in teaching and mentorship. A PhD or equivalent is required at the time of appointment, and postdoctoral research experience is strongly recommended.
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Reposted by Ci Ji (CJ) Lim
Jens Schmidt @jenscs83.bsky.social · 15/09/2026
We are recruiting a postdoctoral fellow to study DNA damage repair via the homologous recombination pathway using quantitative cell biology approaches. The position will be initially supported for two years by the MSU Research Foundation Postdoctoral Scholars program. Please share! 1/5
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Rita Strack @ritastrack.bsky.social · 14/09/2026
I picked up my passport with visa this morning so now I can officially get excited for our conference on Next-Generation Fluorescence microscopy in Beijing this week! natureconferences.streamgo.live/next-generat... It's a really stacked program because basically everyone we invited said yes!
natureconferences.streamgo.live
Next-Generation Fluorescence Microscopy
Organized by Tsinghua University, Nature Photonics, Nature, Nature Biomedical Engineering, Nature Biotechnology and Nature Communications. The conference will highlight key areas in fluorescence micro...
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Sergey Ovchinnikov @sokrypton.org · 14/09/2026
Finally a more intuitaive way to learn pLDDT/pAE? 😎 sokrypton.github.io/protein_figh... (Character idea from @hannes-stark.bsky.social & Alex Waldherr)
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Alex Ludwig @alexludwig.bsky.social · 14/09/2026
Check out our new preprint in which we used cryoCLEM to study the native architecture of the human inactive X chromosome in RPE1 cells. Neil Brockdorff’s group from Oxford posted a similar story, performed in female stem cells. We see individual nucleosomes and other exciting things!
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 14/09/2026
New Online! A practical guide to studying genome function using single-molecule genomics
dlvr.it
A practical guide to studying genome function using single-molecule genomics
Nature Reviews Molecular Cell Biology, Published online: 14 September 2026; doi:10.1038/s41580-026-01017-4Single-molecule genomics methods are used to study the activity of regulatory factors on individual DNA molecules genome-wide, thereby enabling quantification of molecular heterogeneity and co-occurrence of regulatory events. This Expert Recommendation article provides a practical guide for adopting single-molecule genomics and outlines best practices.
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Daniel Kierzkowski @kierzkowskilab.bsky.social · 12/09/2026
🌱We are looking for an Assistant Professor in Plant Molecular Genetics @irbv.bsky.social If you are passionate about genetics, molecular biology, or imaging, this is your chance to join a community of researchers working on plant development, cell biology, evolution, and biodiversity 🧬🔬 🧪🍁
rh-carriere-dmz-eng.synchro.umontreal.ca
Careers
Through your undergraduate and graduate-level teaching, and your research activities, you will contribute to the faculty’s pursuit of excellence. Furthermore, you will promote your discipline and actively participate in the daily activities of a renowned institution. As such, you will:
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Terence Tao @teorth.bsky.social · 11/09/2026
A group of 25 Fields Medalists, including myself, have made a joint declaration on Math and AI: mathandai.org . We welcome additional signatories. See also this article in the Economist announcing the declaration: www.economist.com/science-and-...
mathandai.org
Declaration — Math and AI
Read the declaration and add your name.
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Doc Edge @docedge.bsky.social · 12/09/2026
Please repost: My department (quantitative and computational biology at the University of Southern California) is hiring a teaching-track faculty member. The new hire will focus on teaching statistics courses to biology students. Apply by Dec 1 usccareers.usc.edu/job/los-ange...
usccareers.usc.edu
Full-Time, Teaching-Track Faculty Position in Quantitative and Computational Biology at USC
Learn more about applying for Full-Time, Teaching-Track Faculty Position in Quantitative and Computational Biology at USC
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Janet Iwasa @jiwasa.bsky.social · 09/09/2026
Interested in molecular animation? Give ProteinBlender a try! It's free and open source. animation-lab.github.io/ProteinBlend... The latest tools include a DNA builder (shown in the tutorial video below). We'd love to hear what you think! We have short tutorials that cover all the features!
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 11/09/2026
New Online! PRC2–RNA interactions through the lens of bioinformatics pipeline choices
dlvr.it
PRC2–RNA interactions through the lens of bioinformatics pipeline choices
Nature Reviews Molecular Cell Biology, Published online: 11 September 2026; doi:10.1038/s41580-026-01028-1Four recent studies that have differently assessed PRC2–RNA interactions reveal key technical pitfalls underlying research in the field.
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Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦ @dudinlab.bsky.social · 11/09/2026
We wanted to share this asap for everyone to use ! This will remain a #preprint for the time being. We are happy to recieve feedback, hear whether or not ot works in your hands and continue to apply it across #eukaryotes as part of #ExÂME You want to know more : www.dudinlab.com/exame
dudinlab.com
Research
ExÂME is the Expansion Microscopy Atlas of Microbial Eukaryotes, a community-driven project uncovering the hidden cellular architectures of protists and microbial eukaryotes. Supported by the Moore Fo...
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The Rosalind Franklin Institute @rosfrankinst.bsky.social · 11/09/2026
There’s still time to apply! 📢 We’re hiring a Digital Communications Coordinator for 12 months, helping share the Franklin’s science with key audiences. Based near Oxford. Applications close this Sunday! For more details and to apply: opportunities.rfi.ac.uk/vacancy/digi...
A picture of the Rosalind Franklin Institute building with yellow and blue panels. Text reads 'We are hiring - Digital Communications Coordinator' with the website www.rfi.ac.uk.
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Nature Chemical Biology @natchembio.nature.com · 11/09/2026
Directed evolution of Lantern enables rapid RNA and protein proximity labeling www.nature.com/articles/s41...
nature.com
Directed evolution of Lantern enables rapid RNA and protein proximity labeling - Nature Chemical Biology
Fang, Ren, Zheng, Wang et al. developed Lantern, a variant of miniSOG, through directed evolution for subcellular transcriptomes and proteomes analyses inside living cells, enabling findings that RNA ...
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Timothée Lionnet @successprocess.bsky.social · 11/09/2026
Sharing ZATELLITE 🛰️ - a tool to visualize and manipulate repetitive loci in living cells using designer zinc fingers tinyurl.com/ZATELLITE led by Nestor Saiz, collab with Marcus Noyes, @teresadavoli.bsky.social, @glennislogsdon.bsky.social, @liamholt.bsky.social & @jefboeke.bsky.social (1/n)
principle of ZATELLITE: synthetic Zinc Fingers are fused to a fluorescent protein and targeted to repetitive endogenous sequences - this ensures damage-free tagging, which is not the case with dCas9
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Biophysical Journal @biophysj.bsky.social · 10/09/2026
Special issue call for papers: Single-Molecule Approaches to Reveal Structural and Mechanistic Properties of the Genome. buff.ly/Ify9mW4
biophysics.org
https://www.biophysics.org/Portals/0/BPSAssets/Publications/Documents/BJ_CallForPapers_SingleMoleculeApproaches.pdf#Page=1
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Alex Wild @alexwild.bsky.social · 10/09/2026
Ultimately, this letter from NSF is an announcement that universities will be funded a lot less and politically-connected industry will be funded a lot more. Fancy words around old-fashioned corruption.
nsf.gov
NSF leadership in a new golden age of science
The U.S. National Science Foundation was established in 1950 to keep American discovery at the frontier. That mission has not changed. The science and technology ecosystem around it has...
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Alexis Rohou @alexisrohou.bsky.social · 10/09/2026
Genentech Structural Biology is hiring a Principal Scientist - please share! We're looking for someone with expertise in solving structures and in computational techniques related to dynamics - MD, ensemble modeling, ensemble docking, and/or related methods.
careers.gene.com
Principal Scientist, Structural Biology in South San Francisco, California, United States of America | Research & Development at Genentech
Apply for Principal Scientist, Structural Biology job with Genentech in South San Francisco, California, United States of America. Research & Development at Genentech
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Guillaume Thibault @gthibault.bsky.social · 10/09/2026
Singapore Bioscience Symposium 2026 reminder. Abstract submission and early bird registration both close 30 September. The lineup includes 9 keynotes, 18 invited speakers, 12 countries. Details 🧵👇
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Kazuhiro Maeshima @kazu-maeshima.bsky.social · 08/09/2026
Is euchromatin really “open”? 🧬 Using super-resolution imaging🔬 our new study @natgenet.nature.com reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing for proper transcriptional insulation🚧 🔗 www.nature.com/articles/s41... (1/2)
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Max-Planck-Gesellschaft @maxplanck.de · 09/09/2026
We are hiring! Start at a #MaxPlanckInstitute with your own independent Max Planck Research Group. This position is equivalent to a W2 Professorship at a German university, or Associate Professor internationally. 🔗Apply until October 14th! www.mpg.de/career/max-p... #ScienceCareer #MPRG #TenureTrack
Call for independent Max Planck Research Groups
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Virginia Busetto @virginiabusetto.bsky.social · 08/09/2026
Very excited to share our new preprint: “A pseudohelicase-centered complex couples assembly-dependent RNA cleavage to poly(UG)ylation”! 🎉 Want to know more? 🧵👇 www.biorxiv.org/content/10.6...
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Ci Ji (CJ) Lim @cijilim.bsky.social · 08/09/2026
Congratulations to Toru and the rest of the authors! 🎉 Happy that @souravagrawal.bsky.social and I can be part of this work! Insights into telomerase-RPA interaction using fission yeast as a model system
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