De novo protein design has advanced rapidly, yet designing binders to polar, solvent-exposed epitopes and small, flexible ligands remains challenging. Such hydrated surfaces and flexible molecules, in...

GPN-Star, a genomic language model with a phylogeny-aware architecture for whole-genome alignment data, is shown to be a scalable and flexible tool for genetic variant effect prediction across species...

Comparative and functional analyses of Myotis bats uncover unique patterns of adaptation in virus-interacting proteins and longevity-associated pathways, linking two hallmarks of bat biology.

Nature Biotechnology - Ten thousand interactions for the molecular biologist

This Article demonstrates that direct preference optimization (DPO) can be used to effectively align an unsupervised structure-conditioned language model with biophysical information. The aligned mode...

Structure prediction has reached RNA, where generating deep alignments is now the bottleneck. We developed Riboseek, a search and alignment tool for RNA and DNA that represents sequences as overlappin...

Structural bioinformatics aims to answer biological questions by considering biomolecular structures at scale. This Perspective argues that now that we have accurate predictions, we need to ask what w...

Kimi K3 is the world's first open 3T-class model — frontier performance across coding, knowledge work, and reasoning, with native multimodality and 1M context.

Protein language models have excelled at modeling individual proteins, but extending these capabilities to protein complexes remains a major challenge. MSA Pairformer, a parameter-efficient protein la...

Korea is expanding its elite "top-tier" visa program to encompass foreign professors and researchers as part of an aggressive push to secure global...

There is a lot of debate and some hyperbole around the impact of AI-assisted scientific research. When considering the future impact of gene...

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Folddisco enables protein structural motif search in million scale databases.

Folddisco enables protein structural motif search in million scale databases.

Folddisco enables protein structural motif search in million scale databases.

Folddisco enables protein structural motif search in million scale databases.

FAMSA2 accurately aligns millions of protein sequences at high speed.