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Alexis Rohou

@alexisrohou.bsky.social
1.7K followers 351 following 773 posts

CryoEM and structural biology methods, drug discovery. Also: Celtics, Camus, rocksteady, drum and bass. He, him, his. Disclosure: employee of Roche/Genentech (but expressing my personal views only).

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Alexis Rohou @alexisrohou.bsky.social · 04/10/2026
California scientists. I think I’ll vote no on Prop 38 ($8.4bn bond for immunology research). Some reasons in the SF Chronicle piece below. Others include: I don’t like a ballot measure deciding what science to fund for next 20 years. If it were a broad based fund for all sciences then maybe.
sfchronicle.com
Endorsement: Prop 38 is one of the most noxious deposits on California’s political dung heap in years
OPINION: Prop 38 would give billions to an institute co-founded by billionaire Michael Milken, also known as the “junk bond king,” who was pardoned by Trump in 2020, the editorial board writes.
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Alexis Rohou @alexisrohou.bsky.social · 24/09/2026
Reminder - this job search is still open. If you operate at the ensemble/dynamics/structure determination boundary, please consider applying!
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Alexis Rohou @alexisrohou.bsky.social · 23/09/2026
This is a nice new preprint, where the authors demonstrate fairly rigid (2-point) attachment of gold nanoparticles to Fabs thanks to pairs of engineered cysteines. These are then stabilized for use in labeling experiments by PEGylating them (to prevent reduction by e.g. glutathione).
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Kate Starbird @katestarbird.bsky.social · 23/09/2026
Here's a good test case for our framework, demonstrating how a real incident can be turned into a false "rigged election" rumor or narrative. Here the DOJ highlights a case where a postal worker discarded mail that included ballots, and uses that to suggest voter fraud and untrustworthy elections.
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Martin Pacesa @martinpacesa.bsky.social · 21/09/2026
ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/Bi...
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Alexis Rohou @alexisrohou.bsky.social · 16/09/2026
Pro tip: If a job ad says "please provide a cover letter", then please... provide a cover letter. Grrr. And if your CV might appear weak on an aspect of the job description at first glance, use the cover letter to explain why you believe you are qualified in that particular respect.
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Alexis Rohou @alexisrohou.bsky.social · 10/09/2026
Genentech Structural Biology is hiring a Principal Scientist - please share! We're looking for someone with expertise in solving structures and in computational techniques related to dynamics - MD, ensemble modeling, ensemble docking, and/or related methods.
careers.gene.com
Principal Scientist, Structural Biology in South San Francisco, California, United States of America | Research & Development at Genentech
Apply for Principal Scientist, Structural Biology job with Genentech in South San Francisco, California, United States of America. Research & Development at Genentech
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Daniel Drezner @dandrezner.bsky.social · 28/08/2026
Someone posted a clip of Dolly Parton and her family singing Leadbelly on here and that led to the Nirvana version being my earwom for the last 48 hours so here it is. Possibly the high point for Gen X music, definitely the highlight point for MTV Unplugged. youtu.be/hEMm7gxBYSc?...
youtu.be
Nirvana - Where Did You Sleep Last Night (Live On MTV Unplugged, 1993 / Unedited)
YouTube video by NirvanaVEVO
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George Takei @georgetakei.bsky.social · 25/08/2026
A great loss for us all. A light in our darkness, a talent like none other. Rest in song and mirth, Dolly. The heavens have a new star among them.
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Orin Kerr @orinkerr.bsky.social · 24/08/2026
It's only 12 seconds long, but Louis Armstrong's unaccompanied opening to "West End Blues" still amazes, almost a century after its 1928 recording. The whole song is a beauty. www.youtube.com/watch?v=4WPC...
youtube.com
Louis Armstrong - West End Blues
YouTube video by thechickencompany
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Derek Lowe @dereklowe.bsky.social · 18/08/2026
Thoughts on the latest Alzheimer’s data scandal:
science.org
More Alzheimer's Research Trouble
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Matt Johnson @drmatthewcjohnson.bsky.social · 11/08/2026
Interested in a career in industry cryoEM? We're hiring! We seek a cryoEM/cryoET expert to join our team at Genentech advance our mission to provide high-resolution structural insights into biological macromolecules involved in health and disease. Apply at: careers.gene.com/us/en/job/20...
careers.gene.com
Systems Specialist II in South San Francisco, California, United States of America | Manufacturing & Engineering at Genentech
Apply for Systems Specialist II job with Genentech in South San Francisco, California, United States of America. Manufacturing & Engineering at Genentech
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Alexis Rohou @alexisrohou.bsky.social · 12/08/2026
Come work with us at Genentech. We do drug discovery, pretty cutting edge cryoEM/ET stuff, and always learn a lot together. Any questions or recommendations, do let me know.
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Alexis Rohou @alexisrohou.bsky.social · 12/08/2026
I will be attending #IUCr2026 in Calgary, Wednesday to Sunday. I look forward to catching up with old friends and colleagues and to meeting lots of new people!
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Alexis Rohou @alexisrohou.bsky.social · 08/08/2026
Working from home, the 1979 version
youtu.be
1979: Will WORD PROCESSORS start a HOME WORKING revolution? | Past Predictions | BBC Archive
YouTube video by BBC Archive
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Carl T. Bergstrom @carlbergstrom.com · 23/07/2026
1. The new Trump / Kratsios plan for US science appears explicitly designed to destroy US universities. Diverting money to tech donors is probably just a bonus. Gift link.
nytimes.com
Trump’s Plan for Science: More Money for A.I., Less for Universities (Gift Article)
Michael Kratsios, President Trump’s science adviser, proposed overhauling how the government funds research. Democrats said Mr. Trump’s actions had weakened science.
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Drug Monkey @drugmonkey.bsky.social · 15/07/2026
Sounds like gender-affirming care.
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Harmit Singh Malik @harmitmalik.bsky.social · 14/07/2026
This post wins the day
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Randall Munroe @xkcd.com · 08/07/2026
Offside xkcd.com/3268/
Comic. [chessboard with red dotted line and flag at second line. Highlighted rook is positioned next to King behind the red line.]  [caption] I thought I had checkmate, but I didn’t realize my rook was offside.
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Jeremy Berg @jeremymberg.bsky.social · 02/07/2026
Scott Atlas, the champion of herd immunity as an Fox News commenter and the Trump Advisor during COVID, weighs in with a DEEPLY MININFORMED op-ed in the WaPo. www.washingtonpost.com/opinions/202... 1/7
washingtonpost.com
Opinion | Abolish the NIH
A $48 billion government monopoly should give way to the market.
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Aaron Reichlin-Melnick @reichlinmelnick.bsky.social · 25/06/2026
IMPORTANT to know that the vast majority of Haitians with TPS entered the country legally at ports of entry, not illegally. The majority have NEVER violated the law. The admin stripped their status by breaking the law, but today SCOTUS says courts can't do anything about that.
Chart shows Haitian migrant encounters by entry method, January 2021 to January 2025, showing that after mid-2022, nearly every entry was legal.
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Alexis Rohou @alexisrohou.bsky.social · 22/06/2026
Ten Years After Brexit, the Dismal Verdict Is In www.nytimes.com/2026/06/22/o...
nytimes.com
Opinion | Ten Years After Brexit, the Dismal Verdict Is In
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Ben Engel @cellarchlab.com · 18/06/2026
OK— so @phaips.vd.st & @florentwaltz.bsky.social have been testing extensively, and it's pretty clear that MissAlignment may be the best thing to happen to #TeamTomo in the last couple years. One issue: we have to re-process all our data again, hopefully for the last time 😅. Congrats and THANK YOU!!
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Laura Jedeed @laurajedeed.bsky.social · 17/06/2026
When Trump went to war with Iran, I watched every speech anyone in the administration gave and made a chart of every reason given for going to war "Eliminate ballistic capability" was the #1 reason given: more even than preventing Iran from getting a nuclear weapon
docs.google.com
Iran War Reasons Chart.xlsx
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Alexis Rohou @alexisrohou.bsky.social · 17/06/2026
Great to see a formal treatment of the key problem of how to decide how many conformational states one should even attempt to reconstruct from cryoEM data.
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Basil Greber @bjgreber.bsky.social · 13/06/2026
This should be seen as Musk’s legacy. Not self-driving cars that crash or space rockets that keep exploding. This. All the reporting on Musk’s activities without highlighting the devastation caused by DOGE is extremely irresponsible. www.cnn.com/2026/02/04/w...
cnn.com
One year on from dismantling of USAID, study projects that global aid cuts could lead to 9.4 million deaths by 2030 | CNN
It’s been one year since the Trump administration dismantled the US Agency for International Development (USAID), with aid cuts leading to the closure of HIV clinics in South Africa, the termination o...
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Wolfgang Blau @wblau.bsky.social · 13/06/2026
Edward Luce in the Financial Times about Musk:
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kmbmh.bsky.social @kmbmh.bsky.social · 11/06/2026
Have to read the comments on this one🤣
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Alexander Howard @digiphile.bsky.social · 08/06/2026
“Any fascist attempt to gain power in America would…work under the guise of ‘super-patriotism’ & ‘super-Americanism.’ Fascist leaders are neither stupid nor naive. They know that they must hand out a line that ‘sells.’”-U.S. Army orientation, 1945 archive.org/details/Army... What’s past is prologue.
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Alexis Rohou @alexisrohou.bsky.social · 02/06/2026
Wemby is the Statue of Liberty for the NBA. Technically French, but represents our values.
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Stephen Curry @scurry.bsky.social · 29/05/2026
The trumpocracy at work. Deaths ensue.
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Jeremy Berg @jeremymberg.bsky.social · 29/05/2026
Once again, @dereklowe.bsky.social is not holding back and I am here for it. www.science.org/content/blog... 1/2
science.org
The Current Crisis: What's Happening to Science in America
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Prism Science @prismscienceorg.bsky.social · 28/05/2026
The DiffUSE Project wants examples where structural heterogeneity matters but cannot be encoded in PDBx/mmCIF. X-ray, cryo-EM, time-resolved, multi-map, or fragment screening data welcome. Submit yours: diffuse.science/submit/
diffuse.science
Submit Examples of Heterogeneous Structural Data
The DiffUSE Project
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Michael D. Green, PhD @michaeldgreen.phd · 28/05/2026
President of MIT not mincing words today in @statnews.com www.statnews.com/2026/05/27/s...
So let me say it as clearly as I can: Without basic scientific research, supported by the kind of farsighted public investment that allows large-scale, undirected, curiosity-driven inquiry, the scientific pipeline will run dry.
In daily life, people may not feel the effects right away, or even in 10 years. But we will feel it. And when someone we love needs therapies that could have emerged but didn't or when other countries now
investing in science can launch new science-based industries or run their societies on vast resources of fusion energy or reap the benefits of quantum computing power or advanced medical breakthroughs, America will wish it sustained its leadership in scientific research here and now.
Sally Kornbluth is the president of MIT.
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ArtButMakeItSports @artbutmakeitsports.bsky.social · 28/05/2026
Flirtation, by Eugene de Blaas, 1894
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Alexis Rohou @alexisrohou.bsky.social · 27/05/2026
Spot on. The dangers of rejecting wisdom and expertise. Somewhat analogous, though milder: “A month in the laboratory can often save an hour in the library”.
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Tyler King @tyleraking.com · 27/05/2026
This entire administration is an exercise in discovering why you need government and then scrambling to assemble an arm while cutting off another leg.
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Chemjobber @chemjobber.bsky.social · 26/05/2026
One more thing - this (the life sciences, and its associated products) is, in my opinion, the last place where America has/had the 'commanding heights' and Trump/Russell Vought is 100% trying to give that advantage away. Our children and grandchildren will be poorer and sicker for it.
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Alexis Rohou @alexisrohou.bsky.social · 25/05/2026
Just spent 3+ hours researching candidates and voting in California’s primary. My first vote as a US citizen and it was a lot of work!!
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Aaron Reichlin-Melnick @reichlinmelnick.bsky.social · 18/05/2026
This is THEFT. There is no other word for it. They are stealing almost $1.8 BILLION dollars to pay Trump‘s allies, despite knowing that these people are not legally entitled to any money and be laughed out of court if they filed a lawsuit for money damages.
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Richard Ferro, MD MSc @richferro.com · 13/05/2026
The groundbreaking research into the KRAS protein that led to the development of daraxonrasib was funded in part by the NIH. Public funding is the bedrock of pharmaceutical research.
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 13/05/2026
While BioNtech & Moderna become household names because of their Covid vaccines, those emerged from different projects: finding ways to treat the most challenging cancers. They hypothesized that we could vaccinate patients against their own tumors, & evidence is mounting that they were right! 1/n 🧪
https://www.nature.com/articles/s41586-025-10004-2
Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC

    U. Sahin, M. Schmidt, E. Derhovanessian, A. Cortini, I. Vogler, T. Omokoko, E. Godehardt, S. Attig, S. Newrzela, J. Grützner, N. Bidmon, S. Bolte, S. Brachtendorf, T. Stuhlmann, D. Langer, D. Brüne, J. Blake, A. Feldner, H. Lindman, A. Schneeweiss, M. Eichbaum & Ö. Türeci 
Triple-negative breast cancer (TNBC) is frequently associated with metastatic relapse, even at an early stage1. Here we assessed an individualized neoantigen mRNA vaccine in 14 patients with TNBC following surgery and after neoadjuvant or adjuvant therapy. In peripheral blood of nearly all patients, high-magnitude, vaccine-induced, mostly de novo T cell responses to multiple neoantigens were detected that remained functional for several years. Characterization of individual patients revealed that a large proportion of these T cells developed into two subsets: a late-differentiated phenotype with markers indicative of ‘ready-to-act’ cytotoxic effector T cells, and T cells with a stem cell-like memory phenotype. Eleven patients remained relapse-free for up to six years post-vaccination. Recurrence occurred in three patients: the individual with the weakest vaccine-induced T cell response relapsed, but achieved complete remission on subsequent anti-PD-1 therapy; another patient had a tumour with low major histocompatibility complex (MHC) class I expression with MHC class I-deficient cells growing out under vaccination; and the third patient was BRCA-positive and had a recurrence from a genetically distinct primary tumour. These findings demonstrate the feasibility of individualized RNA vaccines in TNBC, document persistence of vaccine-induced, functional neoantigen-specific T cells and provide insights into possible immune escape mechanisms that will guide future approaches.
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Jesse Eisinger @jeisinger.bsky.social · 13/05/2026
This would constitute one of the most brazen, most appalling acts of corruption in U.S. history. I know we’re numb to all of this but this is a seven-alarm fire. www.nytimes.com/2026/05/12/b...
nytimes.com
Justice Dept. Officials Consider Settling Trump Suit Against I.R.S.
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Alexis Rohou @alexisrohou.bsky.social · 10/05/2026
This is really great work - look forward to using these new improved scattering factors in Servalcat and eventually in other packages.
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cryoEM papers @cryoempapers.bsky.social · 09/05/2026
Measurement of atomic scattering factors by cryoelectron microscopy pubmed.ncbi.nlm.nih.gov/42101996/ #cryoEM
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Alexis Rohou @alexisrohou.bsky.social · 10/05/2026
Not my field but I am generally skeptical of “reproducibility crisis” cries of alarms. AFAICT it has always been very difficult to reproduce cutting-edge science.
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Berna Devezer @devezer.bsky.social · 30/04/2026
📣 The difference between replicable and not replicable is not itself scientifically replicable. 📣 New work with Erkan Buzbas, showing that verdicts such as "X% of results replicated" are based on an inferential machinery that doesn't work. arxiv.org/abs/2604.26268
Screenshot of a paper's title page. Title: "The Difference Between 'Replicable' and 'Not replicable' is not Itself Scientifically Replicable". Authors: Berna Devezer and Erkan O. Buzbas, both at the University of Idaho — Devezer in the Department of Business and the Institute for Modeling Collaboration and Innovation, Buzbas in the Department of Mathematics and Statistical Science. Authors contributed equally. Corresponding author: bdevezer@uidaho.edu.
Abstract: Replication studies estimate the replicability rate of scientific results by aggregating binary verdicts of experiments. Exact replications are rarely attainable, so most replication sequences are non-exact. Experiments differ in ways that matter and do not share a single common data-generating process. We formalize two statistical interpretations of this non-exactness. In a shared latent rate model (benchmark), experiments are exchangeable and depend on a common random replicability rate. In a conditionally independent rates model (operational), each experiment has its own replicability rate drawn independently from a population distribution. Under the shared latent rate model, even small variability among replicability rates induces an irreducible variance floor on the estimated mean replicability rate that cannot be eliminated by adding more replications. Under the conditionally independent rates model, the degree of non-exactness is not identifiable from standard replication data, because one binary verdict per experiment contains no information about between-experiment heterogeneity. Researchers therefore cannot tell which precision regime they are operating in or whether high- and low-replicability sequences can be distinguished in principle. As a result, the usual data structure of one binary verdict per experiment cannot support reliable demarcation between "replicable" and "not replicable" results and systematically understates uncertainty, making high- and low-replicability sequences appear discrim…
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Lucas Farnung @lucas.farnunglab.com · 07/05/2026
🚀 Soft-launching BenchOS today. An agentic OS for molecular & structural biology labs, combining ELN, biologics databases, equipment booking, cryo-EM tracking, cloning tools, and more. Powered by state-of-the-art LLMs to help you plan and run experiments faster. Learn more: BenchOS.ai
benchos.ai
BenchOS - An Operating System for Molecular and Structural Biology
A lab operating system and AI agent for structured molecular and structural biology workflows.
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Stephen Curry @scurry.bsky.social · 05/05/2026
Laurence would be well able for that himself. But he’s right - getting it across is hard. www.theguardian.com/science/occa...
theguardian.com
Say hello to your inner molecules
Why is it so hard to get any real sense of our molecular selves?
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Marten Chaillet @martenchaillet.bsky.social · 03/05/2026
This was a very rewarding 1-year Genentech project thanks to everyone involved, @alisterburt.bsky.social, @dtegunov.bsky.social, Miguel Leung, and Joyce van Loenhout. Software development was done with Alister and Dimitry remotely while I was embedded at the Hubrecht Institute in Utrecht.
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