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marielle

@marielle.bsky.social
476 followers 464 following 37 posts

grad student at mit studying dynamics of (directed) evolution and protein biology with assistance from liquid handling robots.

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Reposted by marielle
Sergey Ovchinnikov @sokrypton.org · 17/09/2026
Introducing highly experimental localfold.org Building on @martinsteinegger.bsky.social af2 webgpu port, @milot.bsky.social optimizations & jax ports of af3-like models by @marielle.bsky.social, Choonghwan Lee, Julia Buhmann. WARNING: runs directly on your 💻, may drain 🪫 & eat data📱 & overheat 🔥💻
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Richard Sever @richardsever.bsky.social · 26/02/2026
New version of our preprint on bioRxiv about bioRxiv up. Now that’s what I call a revision – 6 years after the first version! It has new data about our progress and highlights from a massive user survey. 1/n www.biorxiv.org/content/10.1...
biorxiv.org
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David Gorski, MD, PhD @gorskon.bsky.social · 30/01/2026
It’s going to be political hacks. www.nature.com/articles/d41...
nature.com
Exclusive: key NIH review panels due to lose all members by the end of 2026
Thirteen of the agency’s advisory councils, which must review grant applications before funding is awarded, are on track to have no voting members.
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Federal Reserve @federalreserve.gov · 12/01/2026
Video message from Federal Reserve Chair Jerome H. Powell: www.youtube.com/watch?v=KckG... www.federalreserve.gov/newsevents/s...
youtube.com
Statement by Federal Reserve Chair Jerome H. Powell
YouTube video by Federal Reserve
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Geert Verhoeff @gjverhoeff.bsky.social · 05/01/2026
2026 beginning of the year cleaning up files on my PC and found this one a friend send me when working on some code. Every developer can relate. #solodev #indiedev #development
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Chris Geidner @chrisgeidner.bsky.social · 22/12/2025
Again, from Michael Grynbaum, here is Sharyn Alfonsi's full email. It must be read:
News Team,
Thank you for the notes and texts. I apologize for not reaching out earlier.
I learned on Saturday that Bari Weiss spiked our story, INSIDE CECOT, which was supposed to air tonight. We (Ori and I) asked for a call to discuss her decision. She did not afford us that courtesy/opportunity.
Our story was screened five times and cleared by both CBS attorneys and Standards and Practices. It is factually correct.
In my
view, pulling it now-after every rigorous internal check has been met is not an editorial decision, it is a political one.
We requested responses to questions and/or interviews with DHS, the White House, and the State Department. Government silence is a statement, not a VETO. Their refusal to be interviewed is a tactical maneuver designed to kill the story.
If the administration's refusal to participate becomes a valid reason to spike a story, wehave effectively handed them a "kill switch" for any reporting they find inconvenient.
If the standard for airing a story becomes
"the government must agree to be interviewed," then the government effectively gains control over the 60 Minutes broadcast.
We go from an investigative powerhouse to a stenographer for the state.
These men risked their lives to speak with us.
We have a moral and professional obligation to the sources who entrusted us with their stories. Abandoning them now is a betrayal of the most basic tenet of journalism: giving voice to the voiceless.
CBS spiked the Jeffrey Wigand interview due to legal concerns, nearly destroying the credibility of this broadcast. It took years to recover from that "low point." By pulling this story to shield an administration, we are repeating that history, but for political optics rather than legal ones.We have been promoting this story on social media for days. Our viewers are expecting it.
When it fails to air without a credible
explanation, the public will correctly identify this as corporate censorship. We are trading 50 years of "Gold Standard" reputation for a single week of political quiet.
I care too much about this broadcast to watch it be dismantled without a fight.
Sharyn
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marielle @marielle.bsky.social · 18/11/2025
git operations interfacing with GitHub are NOT working at the moment. sharing here to hopefully save someone else from the time I just spent troubleshooting githubstatus.com
githubstatus.com
GitHub Status
Welcome to GitHub's home for real-time and historical data on system performance.
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Reposted by marielle
Joe Fore @joefore.bsky.social · 14/11/2025
Former UVA president Jim Ryan, who resigned over the summer due to pressure from the Trump Administration, just shared this 12-page letter with the Faculty Senate, detailing his experience with the Board of Visitors and DOJ. It's a surreal--and troubling--read. drive.google.com/file/d/1Is6x...
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Anne Applebaum @anneapplebaum.wsocial.eu · 07/11/2025
Hundreds of thousands of people, dead because of a decision made by the world's richest man
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José Sepúlveda @josesepulveda.bsky.social · 13/10/2025
The cuts amounted to $500 million in funds. Thousands of planned deliveries were canceled without warning in all 50 states, Puerto Rico and Washington, D.C. The #USDA did not respond to questions or requests for comment. Read the story by Ruth Talbot and @nicolesantacruz.bsky.social.
projects.propublica.org
Trump Canceled 94 Million Pounds of Food Aid. Here’s What Never Arrived.
ProPublica obtained records from the Department of Agriculture that detail the millions of pounds of food, down to the number of eggs, that never reached food banks because of the administration’s cut...
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Sheryl Gay Stolberg @sherylnyt.bsky.social · 11/10/2025
BREAKING: Friday night massacre underway at CDC. Doznes of "disease detectives," high-level scientists, entire Washington staff and editors of the MMWR (Morbidity and Mortality Weekly Report) have all been RIFed and received the following notice:
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Kate Riga @kateriga.bsky.social · 06/10/2025
Judge will hand down new TRO that "prohibits the relocation, federalization, or deployment of any National Guard under federal command" "within the state of Oregon"
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Mallory Harris, PhD @malar0ne.bsky.social · 05/10/2025
IMO this hasn't gotten enough attention: a recent memo at NIH announces that peer review will be devalued in determining which grants get funded, granting more power to political appointees to make decisions based on the admin's whims over scientific merit kffhealthnews.org/news/article...
kffhealthnews.org
Changes at NIH Give Political Appointees Greater Power To Fund or Block Research - KFF Health News
The National Institutes of Health’s long-held standard of peer review for grantmaking has been subverted by President Donald Trump and NIH Director Jay Bhattacharya, who gave unprecedented power to po...
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Max Kozlov @maxkozlov.bsky.social · 15/07/2025
NEW: In an unprecedented move, the NIH will soon disinvite dozens of scientists about to take positions on advisory councils that make final decisions on grant funding. NIH staff were told to select others aligned with the Trump administration and told to expect placements by political appointees.
nature.com
Exclusive: NIH to dismiss dozens of grant reviewers to align with Trump priorities
The move would undo years of work, leaving advisory councils understaffed, and without the full expertise needed for reviews.
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Lucas Farnung @lucas.farnunglab.com · 29/09/2025
New week, new tool: Find our Protein Domain Designer tool to generate publication-ready protein domain diagrams here: domaindesigner.farnunglab.com
Protein Domain Designer tool for the generation of publication-ready protein domain diagrams
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Solomon @solomonrmissouri.com · 28/09/2025
www.nbcnews.com/news/us-news...
nbcnews.com
'Highly premeditated' attack at North Carolina waterfront bar leaves 3 dead and 5 wounded
Nigel Max Edge, 40, was charged with three counts of first-degree murder and five counts of attempted murder on Sunday morning.
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David Gilbert @davidgilbert.bsky.social · 25/09/2025
NEW WIRED led the way in reporting on Elon Musk's efforts to dismantle the US government. My colleagues and I spoke to 100s of employees at dozens of agencies to understand what happened. This is the definitive story of DOGE as told by those who experienced it www.wired.com/story/oral-h...
wired.com
The Story of DOGE, as Told by Federal Workers
WIRED spoke with more than 200 federal workers in dozens of agencies to learn what happened as the Department of Government Efficiency tore through their offices.
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Sharon 🪳🌹 @sharonk.bsky.social · 14/09/2025
korean reporting is nightmarish on the conditions Korean workers were contained in
Their waists and hands were tied together, forcing them to bend down and lick water to drink. The unscreened bathrooms contained only a single sheet to cover their lower bodies. Sunlight barely penetrated through a fist-sized hole, and they were only allowed access to the small yard for two hours. Detained by US immigration authorities for eight days, the workers and their families expressed shock, describing human rights violations and absurdities they could not have imagined as ordinary Koreans living in 2025.
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Axios @axios.com · 19/09/2025
JUST IN: Bureau of Labor Statistics postpones key inflation data report
trib.al
Bureau of Labor Statistics postpones key data report with no explanation
There is heightened concern about the future of key government statistics, including politicization and accuracy.
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Don Moynihan @donmoyn.bsky.social · 19/09/2025
President of Texas A&M resigns. This is the second Texas A&M President chased out of College Station in two years as a result of right wing politicians and activists attacks on academic freedom. www.nytimes.com/2025/09/18/u...
nytimes.com
Texas A&M President to Step Down After Controversy Over ‘Gender Ideology’
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Dr. Vin Gupta @vinguptamd.bsky.social · 17/09/2025
Regardless of the disgraceful nonsense we will likely hear from this administration in the coming days on vaccine “recommendations,” Americas healthcare insurers issued a joint statement tonight saying coverage for Covid and flu shots will remain unchanged from prior years. Speaks for itself.
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max tani @maxtani.bsky.social · 18/09/2025
The union representing the musicians from Jimmy Kimmel’s band releases a statement calling the FCC’s pressure on Disney “state censorship.”
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Rima I Anabtawi @rimaanabtawi.bsky.social · 16/09/2025
"I urge every government, every leader and every citizen to ask: What will we say when our children and grandchildren ask what we did while Gaza was burned to the ground? Every act of genocide is a test of the humanity that binds us." www.nytimes.com/2025/09/16/o...
nytimes.com
Opinion | My U.N. Commission’s Finding: Israel Is Committing Genocide
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David Manning @photodave219.fightins.online · 14/09/2025
Its H.R. 5300, "To guide the foreign policy of the United States, and for other purposes." This is a five-alarm fire.
‘‘(1) ISSUANCE.—Subject to subsection (b), the
2 Secretary of State shall refuse to issue a passport to
3 any individual who—
4 ‘‘(A) has been charged with or convicted of
5 a violation of section 2339A or 2339B of title
6 18, United States Code; or
7 ‘‘(B) the Secretary determines has know
8 ingly aided, assisted, abetted, or otherwise pro
9 vided material support to an organization the
10 Secretary has designated as a foreign terrorist
11 organization pursuant to section 219 of the Im12 migration and Nationality Act (8 U.S.C. 1189).
13 ‘‘(2) REVOCATION.—The Secretary of State
14 shall, except as provided in paragraph (3)(A), revoke
15 a passport previously issued to any individual de16 scribed in paragraph (1).
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Don Moynihan @donmoyn.bsky.social · 13/09/2025
The reality is that universities, faculty and students are living through an unprecedented assault on speech rights. If you care about protecting speech on campus, that is the battle. Weiss mostly doesn't care abt Trump clamping down on campus speech, because she is largely aligned with his goals.
In the last couple of years, students in America have seen their free speech rights aggressively contested by government. Those lacking citizenship protections have been jailed or deported for speech. Fearful of not appearing sufficiently punitive, universities have withheld diplomas from students purely for their speech. The government is currently engaged in an obvious and massive viewpoint discrimination lawfare campaign against campuses in an effort to control campus speech. If students are becoming more skeptical of free speech, as The Free Press suggests, perhaps it is because while they hear much about the importance of free speech, it is plain to them that their supposed speech rights are all too easily abrogated.
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Anna Bower @annabower.bsky.social · 12/09/2025
Well, well, well, how about that: “Exclusive: Fed Governor Cook declared her Atlanta property as ‘vacation home,’ documents show” www.reuters.com/world/us/fed...
reuters.com
Exclusive: Fed Governor Cook declared her Atlanta property as “vacation home,” documents show
A loan estimate for an Atlanta home purchased by Lisa Cook, the Federal Reserve governor accused of mortgage fraud by the Trump administration, shows that Cook had declared the property as a “vacation home,” according to a document reviewed by Reuters.
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lauren @lauren.rotatingsandwiches.com · 09/09/2025
no, really: nazi shit (richard evans' Third Reich in Power)
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David_j_roth @davidjroth.bsky.social · 09/09/2025
Unbelievable levels of Texas A&M Mindset here. We've never seen numbers like this.
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Lauren Weber @laurenweberhp.bsky.social · 08/09/2025
Meet the new vaccine panel advisors RFK Jr. is considering Two urged removal of mRNA coronavirus vaccines. One said physicians “blindly believed” in them. Another said covid isn’t “scary” noting Jesus touched lepers W @lenasun.bsky.social @washingtonpost.com www.washingtonpost.com/health/2025/...
washingtonpost.com
RFK Jr. considers critics of coronavirus shots to join key vaccine panel
Two urged removal of mRNA coronavirus vaccines. One said physicians “blindly believed” in them. Another said covid isn’t “scary,” noting Jesus touched lepers.
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Vinni Ott @vlott.bsky.social · 29/08/2025
New paper for anyone working with data: Better data viz - for free, in few clicks. Below, all N = 111, M = 0.04, SD = 0.27. One-sided t-tests vs. 0 yield: t(110) = 1.67, p = .049. Use raincloud plots. Or risk wrong conclusions! Plot w/ @jaspstats.bsky.social today! 🧪 📊 #PsychSciSky #StatsSky 🧵👇
Figure 2 from the linked article.Abstract of the linked article
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Ben Goult @bengoult.bsky.social · 28/08/2025
Excited to share our new preprint in @biorxiv-neursci.bsky.social "Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains" Instead of a 🧵 the paper is summarised in this video. www.biorxiv.org/content/10.1...
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Scott Delaney @scott-delaney.bsky.social · 29/08/2025
It's also key to note that NIH thinks it'll have more power to terminate grants for policy reasons starting Oct 1. See earlier reporting from @aniloza.bsky.social. It's possible OGC / NIH is simply waiting to re-terminate until after Oct 1 so they can rely on this (still legally dubious) power. 8/
statnews.com
HHS devises legal playbook for future grant terminations, internal memo shows
Exclusive: HHS devises a legal playbook for future research grant terminations, an internal memo shows.
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Dan Garisto @dangaristo.bsky.social · 29/08/2025
BREAKING: per email sent to agency staff NIH will _NOT_ reterminate the ~900 grants which were reinstated. "[W]e would strongly recommend against re-terminating such grants, because it will likely be viewed as a reapplication of the now-vacated Challenged Directives."
After conferring with DOJ, we'd like to provide the following guidance on the implications of last week's Supreme Court's decision. First, the Challenged Directives identified in the Rite to adamante o tune romain verated and cannot be applied to the identified plaintiffs in the two cases going forward. Second, for any terminated grant that has nc already been reinstated, NIH may stop all work toward reinstating those few grants, if any. Third, for those grants reinstated by NIH in response to the June judgments, we would strongly recommend against re-terminating such grants, because it will likely be viewed as a reapplication of the now-vacated Challenged Directives. We would also refer you to the Acting General Counsel's attached 6/25/25 opinion on the legal risks in terminating awards for nonalignment with priorities at this time.
The Supreme Court's decision was an interim order while the cases proceed with the appeals of the phase 1 judgements before the First Circuit Court of Appeals. We will keep you posted on those proceedings. In the interim, please let us know if you have any questions.
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Olúfẹ́mi O. Táíwò @olufemiotaiwo.bsky.social · 28/08/2025
"Tao is one of the most prominent mathematicians and academics to publicly oppose the administration’s actions, calling them an “existential threat” to his field, and academic science, more broadly. He said public advocacy is a priority over his research, for now." www.nbcnews.com/science/scie...
nbcnews.com
The 'Mozart of Math' rarely speaks about politics. The wide-ranging cuts to science funding made him change that.
UCLA's Terence Tao called the Trump administration's actions an "existential threat" to academic research in the U.S.
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Steve Inskeep @steveinskeep.bsky.social · 27/08/2025
Wow. On NPR, @gbrumfiel.bsky.social reports a Social Security official “copied the Social Security numbers, names and birthdays of over 300 million Americans to a private section of the agency's cloud.” The source is a whistleblower, who is named: Charles Borges, SSN chief data officer.
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The Daily Beast @thedailybeast.bsky.social · 25/08/2025
EXCLUSIVE: The Trump administration will move to pull the COVID vaccine off the U.S. market “within months,” one of Robert F. Kennedy Jr.’s closest associates has told the Daily Beast.
trib.al
Trump and RFK Jr. to Ban Covid-19 Vaccine ‘Within Months’
A close associate of the HHS secretary claims the U.S. government will soon pull COVID-19 mRNA jabs from the market.
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Gregg Gonsalves @gregggonsalves.bsky.social · 21/08/2025
There is no solace for NIH funded researchers in this Supreme Court decision. Grants that were ripped away on dubious grounds, restored by a reasonable judge are now again terminated by an out-of-control Supreme Court. Labs will shutter, people will lose jobs. www.reuters.com/world/us/us-...
reuters.com
US Supreme Court lets Trump cut diversity-related NIH grants
The U.S. Supreme Court let President Donald Trump's administration on Thursday proceed with sweeping cuts to National Institutes of Health grants for research related to racial minorities or LGBT people, part of his crackdown on diversity, equity and inclusion initiatives and transgender identity.
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Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social · 08/08/2025
Nice containerization of AlphaFold, Boltz, and Chai, and calculation of metrics (including our ipSAE score for protein-protein interactions). www.biorxiv.org/content/10.1...
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Dr. David Miller 🏳️‍🌈 @davidimiller.bsky.social · 10/07/2025
🧪 BREAKING (good news): Senate subcommittee says NO! to Trump's proposed slashes to NASA & NSF funding. Today, the subcommittee said to keep NASA + NSF funding at $33.9 billion, the same as in FY24. See 7:15 below. Full Senate appropriations committee meets tomorrow about it. 🧵 1/3
appropriations.senate.gov
Subcommittee Markup of the Commerce, Justice, Science, and Related Agencies Appropriations Act | United States Senate Committee on Appropriations
United States Senate Committee on Appropriations
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Jerónimo Rodríguez-Beltrán @jerorb.bsky.social · 02/07/2025
🚨🚨New paper out in @natcomms.nature.com!! Come for the first large-scale analysis of plasmid copy number across species, stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬 👉 www.nature.com/articles/s41...
nature.com
Universal rules govern plasmid copy number - Nature Communications
Plasmids exhibit a broad range of sizes and copies per cell, and these two parameters appear to be negatively correlated. Here, Ramiro-Martínez et al. analyse the copy number of thousands of diverse b...
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Max Kozlov @maxkozlov.bsky.social · 17/06/2025
After ruling the NIH grant cuts were illegal yesterday, Judge Young, a Reagan appointee on the bench since 1985, ended the hearing with a blistering 15-minute speech. I've cleaned up my notes — here are his remarks in full. 🧵
nature.com
Judge rules against NIH grant cuts — and calls them discriminatory
The decision means that the US biomedical agency has to restore funding to hundreds of research projects, but the government will likely appeal.
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Dominik Niopek @dominikniopek.bsky.social · 13/06/2025
Check out the new pre-print from our lab on phage-assisted evolution of light-switchable, allosteric proteins. Congrats to first author @neuroscinikolai.bsky.social, co-corresponding author @jmathony.bsky.social and everyone from the @niopeklab.bsky.social involved! www.biorxiv.org/content/10.1...
biorxiv.org
Phage-Assisted Evolution of Allosteric Protein Switches
Allostery, the transmission of locally induced conformational changes to distant functional sites, is a key mechanism for protein regulation. Artificial allosteric effectors enable remote manipulation...
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Annie Waldman @anniewaldman.bsky.social · 13/06/2025
I've spent the last few months examining the +1,450 grants terminated at the NIH, including reading hundreds of abstracts. Many were studying how to solve or improve health disparities – not just identify or explain them. Some of the terminated grants (h/t to @scott-delaney.bsky.social + team)
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 10/06/2025
Elizabeth was a remarkable leader who helped craft many important improvements in how NIH grants are reviewed. Her removal is just another example of how the system is being demolished.
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Kyle Griffin @kylegriffin1.bsky.social · 09/06/2025
Breaking:   WASHINGTON (AP) - Health secretary removes every member of scientific committee that advises the CDC on how vaccines should be used.
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Stand Up for Science! @standupforscience.net · 09/06/2025
🚨BREAKING: 300+ NIH employees call out the harm of censorship & politicized science in scathing email to Bhattacharya, demanding an end to political interference, a lift on funding freezes, & rehiring of fired staff whose work saves lives. This is historic - insiders are blowing the whistle. 🧵(1/5)
Front-page-style graphic titled “BREAKING NEWS” with photos of RFK Jr. and Dr. Bhattacharya in front of a government hearing chamber. Text reads: “NIH Scientists Sound the Alarm as Health Research Faces Historic Threat” and “NIH Employees Send Trump Cronies Scathing Wake-Up Call.”
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Arrianna Marie Planey, PhD MA @arrianna-planey.bsky.social · 05/06/2025
And here we go... #EMTALA
kffhealthnews.org
Hospitals Aren't Required to Perform Emergency Abortions, Feds Now Say - KFF Health News
In reversing the Biden-era guidance, the Trump administration has lifted EMTALA measures that allowed doctors to perform abortions when necessary, irrespective of the legality of the procedure in the ...
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Carl T. Bergstrom @carlbergstrom.com · 02/06/2025
"Senior officials at the US Department of Veterans Affairs have ordered that VA physicians and scientists not publish in medical journals or speak with the public without first seeking clearance from political appointees of Donald Trump, the Guardian has learned."
theguardian.com
Exclusive: US veterans agency orders scientists not to publish in journals without clearance
Move that seeks political control of doctors’ and scientists’ published research fits a pattern of censorship by the Trump administration, veterans advocates say
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