Doug Kojetin @dougkojetin.bsky.social · 23/09/2026Apply today to be my colleague at Vanderbilt in the Department of Biochemistry!  01220
Reposted by Doug KojetinDrug Monkey @drugmonkey.bsky.social · 24/11/2025Confirmation of the new triage line at 65-70% of proposals. Introduction of a new “competitive but ND” class to permit exception pay pickups. 42921
Reposted by Doug KojetinKatharina Schmack @kathaschmack.bsky.social · 18/11/2025Introducing the 𝐏𝐈-𝐚𝐭-𝐜𝐨𝐧𝐟𝐞𝐫𝐞𝐧𝐜𝐞 𝐒𝐥𝐚𝐜𝐤 𝐦𝐨𝐝𝐞! 🤯 When activated, it will auto-reply to your PI's frantic ideas for new experiments, analyses, and projects with "Great suggestion! Saving this for later" (aka: let's talk when you’re back and got some sleep) #sfn2025 #sfn25 212619
Reposted by Doug KojetinStephanie Wankowicz @stephanieaw.bsky.social · 27/09/2025TTPD #7 with @fraserlab.com. We chatted about the recent meetings, news, preprint engagement notifications, and the point of rotations. wankowiczlab.com/2025/09/27/T... Spotify: open.spotify.com/episode/0JCB...wankowiczlab.comThe Tortured Proteins Department, Episode 7This is the official web page for the Stephanie Wankowicz Lab at Vanderbilt University. 1124
Reposted by Doug KojetinJeremy Berg @jeremymberg.bsky.social · 25/09/2025Since there is some discussion that NIH institutes should not simply use paylines to determine which grants to fund, I thought I would share some old data. These are plots of funding probability fas a function of percentile score for 9 institutes. 1/7 47429
Reposted by Doug KojetinDrug Monkey @drugmonkey.bsky.social · 15/09/2025So that adds up to 340 new R01 that were not funded in this past week alone, due to the multi-year funding mandate. sorry, "strong suggestion". 02714
Reposted by Doug KojetinStephanie Wankowicz @stephanieaw.bsky.social · 12/08/2025I am all for journal caps but $2000 is too low. As @peiferlabunc.bsky.social said, it costs $ to run a journal. 062
Reposted by Doug KojetinJenna Norton @jenna-m-norton.bsky.social · 30/07/2025Today #NIH leadership were told no funds can go out for research project grants, R&D contracts or training grants. We have just a couple weeks to get funds out the door before Russel Vought attempts a #PocketRescission on Aug 15. Even if this ends up being temporary, it’s time we don’t have. 37446
Reposted by Doug KojetinSeth Tomchik @sethtomchik.bsky.social · 26/07/2025I wrote a commentary for the Sun-Sentinel about training as a scientist in South Florida and the role/importance of federal funding for biomedical research. While focused on Florida, it applies broadly. Gift link, feel free to share: www.sun-sentinel.com/2025/06/14/d...sun-sentinel.comDon’t let the light of science dim in the Sunshine State | OpinionSeth Tomchik received his undergraduate and graduate training in South Florida and went on to run a Scripps Florida lab before moving to the University of Iowa. Federal funding for scientific resea… 064
Reposted by Doug KojetinFabien Ferrage @fabferrage.bsky.social · 17/05/2025In France, we are very grateful for the support of @cnrs.fr and #Infranalytics that allows us to access the 1.2 GHz spectrometer in Lille for free (upon selection of proposals of course). 0192
Reposted by Doug KojetinNicholas Fitzkee @fitzkeelab.bsky.social · 14/05/2025Anyone have a lead on replacement syringes for Malvern VP-ITC instruments? They no longer sell them, and they want me to upgrade to the PEAQ system. Unfortunately, we have a PEAQ-ITC, and it doesn't work with the concentrations needed for nanoparticle experiments. #chemsky #biophysics #ITC 155
Reposted by Doug KojetinKevin Gardner @nmrkaygee.bsky.social · 14/05/2025Basic science saves lives and fuels the economy, which is why I’m advocating for: ➡️NIH & NSF to spend FY25 funds ➡️$51.3B for NIH, $9.9B in FY26 ➡️Restoration of many canceled NIH & NSF grants Act now. Contact your lawmakers today: asbmb.quorum.us/campaign/123.... #ScienceServesUsAll #ASBMBAdvocatesasbmb.quorum.usUrge Congress to re-establish the U.S. as the Leader in InnovationAmerican Society For Biochemistry And Molecular Biology 0185
Reposted by Doug KojetinDrug Monkey @drugmonkey.bsky.social · 09/05/2025No-cost extensions of NIH grants are no longer automatically approved drugmonkey.wordpress.com/2025/05/09/n...drugmonkey.wordpress.comNo-cost extensions of NIH grants are no longer automatically approvedThe no-cost extension (NCE) allows the recipient of a NIH grant to continue to spend on the project after the original award interval has expired. This NIH website explains the way NCE used to work… 11324
Reposted by Doug KojetinDerek Lowe @dereklowe.bsky.social · 09/05/2025Heavy water isn’t water. That goes for protein NMR experiments and for a lot else besides:science.orgHeavy Water in Your NMR Experiments, And Elsewhere 1337
Reposted by Doug KojetinVanderbilt Center for Structural Biology @vanderbiltcsb.bsky.social · 11/04/2025Here @cameronicohen.bsky.social dives into the new findings from the @dougkojetin.bsky.social & the John Yang labs ... "From activation to repression: decoding the impact of PPARγ ligands on ligand-binding domain conformation" bit.ly/43P7xJG @vubasicsciences.bsky.social @vanderbilt.edu 043
Reposted by Doug Kojetinboehninglab @boehninglab.com · 02/05/2025NIH adds about 100 billion/yr to the economy 0113
Reposted by Doug Kojetinboehninglab @boehninglab.com · 02/05/2025Budget released today: 40% cut to NIH 50% cut to NSF If enacted, this will destroy academic research in the United States. It will also have a major trickle down effect on the entire academic ecosystem 19577244
Reposted by Doug KojetinDylan Burnette @mag2art.bsky.social · 28/04/2025Burnette lab graduate student, Zach Sanchez, won the Steve Hann Outstanding Graduate Student Award! He then gave a fun talk on blebbisomes! You can read about his work here: nature.com/articles/s41... @vubasicsciences.bsky.social 071
Reposted by Doug KojetinJeremy Berg @jeremymberg.bsky.social · 27/04/2025TV watching recommendations The lead story on 60 Minutes tonight is about NIH and concerns about damage done and continuing during the current administration. 1/2 18870212
Doug Kojetin @dougkojetin.bsky.social · 25/04/2025Looking forward to digging into this new @natchembio.nature.com review article by my colleague @stephanieaw.bsky.social (and @fraserlab.com)! @vanderbilt.edu @vumedicine.bsky.social @vanderbiltcsb.bsky.social pubmed.ncbi.nlm.nih.gov/40275100/pubmed.ncbi.nlm.nih.govAdvances in uncovering the mechanisms of macromolecular conformational entropy - PubMedDuring protein folding, proteins transition from a disordered polymer into a globular structure, markedly decreasing their conformational degrees of freedom, leading to a substantial reduction in entr... 043
Reposted by Doug KojetinML for Protein Engineering Seminar @ml4proteins.bsky.social · 22/04/2025Next Tues (4/29) at **4:30PM** ET, we will have @ginaelnesr.bsky.social @hkws.bsky.social present "Learning millisecond protein dynamics from what is missing in NMR spectra" Paper: biorxiv.org/content/10.1... Sign up on our website for zoom links!biorxiv.orgLearning millisecond protein dynamics from what is missing in NMR spectraMany proteins’ biological functions rely on interconversions between multiple conformations occurring at micro-to millisecond (µs-ms) timescales. A lack of standardized, large-scale experimental data ... 02011
Reposted by Doug KojetinJeremy Berg @jeremymberg.bsky.social · 20/04/2025Some new language appeared in the HHS Grants Policy Statement last week. It doesn't apply to NIH grants (yet) 1/nmedia.tenor.coma man is sitting at a table in a kitchen with the words ermah-gerd written on the screen behind him .ALT: a man is sitting at a table in a kitchen with the words ermah-gerd written on the screen behind him . 26232
Reposted by Doug KojetinArdem Patapoutian @ardemp.bskyverified.social · 20/04/2025In science, we don’t give negative data nearly enough love. Showing with genetic precision that CGRP and Substance P aren’t needed for different kinds of acute and chronic pain? That’s huge. 1467
Reposted by Doug KojetinMatt Sikora @mjsikora.bsky.social · 20/04/2025Peer networks are so important. We built @nrimpact.bsky.social for this reason, and while we did not anticipate *waves hands wildly* when we put the group together in 2019, the 46 faculty in our group lean on each other in times of personal and professional challenges. www.nrimpact.comnrimpact.comNR IMPACT 071
Reposted by Doug KojetinVanderbilt School of Medicine Basic Sciences @vubasicsciences.bsky.social · 18/04/2025Congrats to Kelly O’Rourke, the Department of Biochemistry's Trainee of the Month! 👏🏾👏👏🏻👏🏽 Kelly works in the lab of @dougkojetin.bsky.social and her advice for other students Make self-care a priority. "When I have balance in other areas of my life, I feel more productive and motivated in the lab." 043
Reposted by Doug KojetinStephanie Wankowicz @stephanieaw.bsky.social · 15/04/2025The Tortured Proteins Department Esp. 2 with @fraserlab.bsky.social is out! In addition to bantering about the craziness of the times, we chat about some recent exciting preprints (see links below). open.spotify.com/show/10PHVou...creators.spotify.comEpisode 2: Cool Science Among Continued Uncertainty by The Tortured Proteins DepartmentWe chatted about the continued chaos of science infrastructure and dived into some cool science from recent meetings Jaime and Stephanie attended. We introduce two new segments: preprints and how to d... 1126
Reposted by Doug KojetinStephanie Wankowicz @stephanieaw.bsky.social · 31/03/2025Join us for the 2nd Macromolecular Conformational Ensembles Conference on June 9th/10th at UCSF. The most compelling questions in structural biology cannot be effectively addressed using only a single structure. conformationalensembles.github.io @fraserlab.bsky.socialconformationalensembles.github.ioConformational Ensemble 22313
Reposted by Doug KojetinVanderbilt Center for Structural Biology @vanderbiltcsb.bsky.social · 07/04/2025⚓️It's VU Giving Week! Support the CSB and the Anne Karpay Award in Structural Biology! Your gift supports innovation and discovery across Vanderbilt. Every gift makes a difference! 🧪🔬 Give to the CSB: www.givecampus.com/campaigns/57... Give to the Karpay Award: www.givecampus.com/campaigns/57... 011
Reposted by Doug KojetinJeremy Baskin @jeremybaskin.bsky.social · 03/04/2025Groundbreaking study in Cell from @leventallab.bsky.social: phospholipid asymmetry is a defining feature of the plasma membrane and cholesterol fills the holes — major implications for how this membrane works. A #lipidtime must-read! www.cell.com/cell/abstrac...cell.comCell membranes sustain phospholipid imbalance via cholesterol asymmetryThis work challenges a major assumption in cell biology by showing that lipid bilayers can have drastically different phospholipid abundances between their two leaflets. This lipid abundance asymmetry... 219980
Doug Kojetin @dougkojetin.bsky.social · 30/03/2025Sunday morning elliptical workout entertainment thanks to @stephanieaw.bsky.social @fraserlab.bsky.social 0101
Reposted by Doug KojetinBiology Open @biologyopen.bsky.social · 25/03/2025We are excited to be launching the next phase of our Fast & Fair peer review initiative: offering high-quality peer review within 7 working days. #fastandfairpeerreview Read the Editorial by EiC Daniel Gorelick @danielgorelick.bsky.social at: bit.ly/4kYD1mL 25026
Doug Kojetin @dougkojetin.bsky.social · 25/03/2025Fast, fair, and PAID peer review! WTG @danielgorelick.bsky.social 🙌 051
Reposted by Doug KojetinKatrin Karbstein Lab @kkarbstein.bsky.social · 14/03/2025RNA2025 will feature long talks by: Jennifer Doudna David Tollervey Ling-Ling Chen Matt Disney Tracy Johnson Erin Schuman And 151(!!!) high quality additional talks. Great engagement at poster sessions. Many prizes. Stay at the conference site. Be there or be square! 162
Doug Kojetin @dougkojetin.bsky.social · 28/02/2025Now published! Read our newest story! doi.org/10.1038/s414...doi.orgLigand efficacy shifts a nuclear receptor conformational ensemble between transcriptionally active and repressive states - Nature CommunicationsPPARγ nuclear receptor ligand activities can span agonism to inverse agonism. Here, the authors use NMR to show how chemical changes within a ligand series shift the receptor’s dynamic conformational ... 0106
Reposted by Doug KojetinJeremy Berg @jeremymberg.bsky.social · 26/02/2025ATTENTION The Washington Post is collecting data about funding issues. Please consider contributing. thewashingtonpost.formstack.com/forms/scient...thewashingtonpost.formstack.comAre you a scientist who has lost funding or grants in recent weeks? - Formstack 73180147
Reposted by Doug KojetinKatie Sandlin @kmsandlin.bsky.social · 14/02/2025I maxed out my credit card, emptied my savings account, and took out a loan to move from Alabama to Bethesda, MD. I don’t even qualify for unemployment since I’ve only worked at NIH for a month. I will be financially and medically devastated. Seeking suggestions for anywhere that’s hiring!! 665114424046
Reposted by Doug KojetinArdem Patapoutian @ardemp.bskyverified.social · 13/02/2025😳🤯. Dr. Laurer was the coauthor of the memo yesterday acknowledging that the NIH funding freeze was illegal and directing staff to resume issuing grants. 29031
Reposted by Doug KojetinDaniel Gorelick @danielgorelick.bsky.social · 11/02/2025We need one of these for our lab 061
Reposted by Doug KojetinCarolyn Bertozzi @carolynbertozzi.bskyverified.social · 10/02/2025This is an amazing achievement - angstrom scale imagine of glycan molecules, what a great time for #glycotime. Congrats Leonhard Möckl! www.biorxiv.org/content/10.1...biorxiv.orgAngstrom-resolution imaging of cell-surface glycansGlycobiology is rooted in the study of monosaccharides, Angstrom-sized molecules that are the building blocks of intricate glycosylation patterns. Glycosylated biomolecules form the glycocalyx, a dens... 19419
Doug Kojetin @dougkojetin.bsky.social · 10/02/2025Application deadline extended to Feb 14, 2025! Do you know any undergraduate students interested in structural biology? Check out this summer program at Meharry Medical College in Nashville TN! 022
Reposted by Doug KojetinDaniel Gorelick @danielgorelick.bsky.social · 10/02/2025Trainees who applied for an NIH diversity fellowship whose applications were withdrawn/not being reviewed, there's a NYTimes reporter who wants to talk, especially interested in applicants with disabilities. DM me & I'll put you in touch, will keep all contact confidential. Please amplify 8210191
Reposted by Doug KojetinCarolyn Bertozzi @carolynbertozzi.bskyverified.social · 09/02/2025Cool paper using LLM to discover a protein sequence code for subcellular localization 👏 www.science.org/doi/10.1126/...science.orgProtein codes promote selective subcellular compartmentalizationCells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote... 623568
Reposted by Doug KojetinSri Kosuri @srikosuri.bsky.social · 08/02/2025It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases. 841009846
Reposted by Doug KojetinJohn Streicher @johnstreicher.bsky.social · 08/02/2025Hey all, I know it’s a sewer, but the main action and fight on the NIH is over on Twitter. We could use your voice. I’ve already been contacted by reporters based on posts over there, it’s your best chance to be heard. 14328
Reposted by Doug KojetinTim Clancy @viewfromarchstreet.com · 08/02/2025On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...grants.nih.govNOT-OD-24-110: Notice of Legislative Mandates in Effect for FY 2024NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Legislative Mandates in Effect for FY 2024 NOT-OD-24-110. NIH 7835911467
Reposted by Doug KojetinCarl T. Bergstrom @carlbergstrom.com · 07/02/2025White House budget proposal may slash NSF funding from 9 billion to 3 billion a year.arstechnica.comWhite House budget proposal could shatter the National Science Foundation“This kind of cut would kill American science and boost China.”… 27581305