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Doug Kojetin

@dougkojetin.bsky.social
1.1K followers 1.1K following 43 posts

Structural biology, biophysics, biochemistry, molecular and cellular pharmacology | nuclear receptors | NMR | Vanderbilt University, School of Medicine Basic Sciences, Department of Biochemistry | kojetinlab.org

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Doug Kojetin @dougkojetin.bsky.social · 23/09/2026
Apply today to be my colleague at Vanderbilt in the Department of Biochemistry! 
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Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 17/06/2026
This is jaw-dropping.
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Drug Monkey @drugmonkey.bsky.social · 24/11/2025
Confirmation of the new triage line at 65-70% of proposals. Introduction of a new “competitive but ND” class to permit exception pay pickups.
Details on altered peer review including the new triage line for 65-70% of apps.
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Katharina Schmack @kathaschmack.bsky.social · 18/11/2025
Introducing the 𝐏𝐈-𝐚𝐭-𝐜𝐨𝐧𝐟𝐞𝐫𝐞𝐧𝐜𝐞 𝐒𝐥𝐚𝐜𝐤 𝐦𝐨𝐝𝐞! 🤯 When activated, it will auto-reply to your PI's frantic ideas for new experiments, analyses, and projects with "Great suggestion! Saving this for later" (aka: let's talk when you’re back and got some sleep) #sfn2025 #sfn25
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Doug Kojetin @dougkojetin.bsky.social · 06/11/2025
Happy to serve! 🧲 #NMR
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Stephanie Wankowicz @stephanieaw.bsky.social · 27/09/2025
TTPD #7 with @fraserlab.com. We chatted about the recent meetings, news, preprint engagement notifications, and the point of rotations. wankowiczlab.com/2025/09/27/T... Spotify: open.spotify.com/episode/0JCB...
wankowiczlab.com
The Tortured Proteins Department, Episode 7
This is the official web page for the Stephanie Wankowicz Lab at Vanderbilt University.
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Jeremy Berg @jeremymberg.bsky.social · 25/09/2025
Since there is some discussion that NIH institutes should not simply use paylines to determine which grants to fund, I thought I would share some old data. These are plots of funding probability fas a function of percentile score for 9 institutes. 1/7
Graphs of funding curves for nine NIH institutes from fiscal year 2012.
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Drug Monkey @drugmonkey.bsky.social · 15/09/2025
So that adds up to 340 new R01 that were not funded in this past week alone, due to the multi-year funding mandate. sorry, "strong suggestion".
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Stephanie Wankowicz @stephanieaw.bsky.social · 12/08/2025
I am all for journal caps but $2000 is too low. As @peiferlabunc.bsky.social said, it costs $ to run a journal.
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Jenna Norton @jenna-m-norton.bsky.social · 30/07/2025
Today #NIH leadership were told no funds can go out for research project grants, R&D contracts or training grants. We have just a couple weeks to get funds out the door before Russel Vought attempts a #PocketRescission on Aug 15. Even if this ends up being temporary, it’s time we don’t have.
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Seth Tomchik @sethtomchik.bsky.social · 26/07/2025
I wrote a commentary for the Sun-Sentinel about training as a scientist in South Florida and the role/importance of federal funding for biomedical research. While focused on Florida, it applies broadly. Gift link, feel free to share: www.sun-sentinel.com/2025/06/14/d...
sun-sentinel.com
Don’t let the light of science dim in the Sunshine State | Opinion
Seth Tomchik received his undergraduate and graduate training in South Florida and went on to run a Scripps Florida lab before moving to the University of Iowa. Federal funding for scientific resea…
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Fabien Ferrage @fabferrage.bsky.social · 17/05/2025
In France, we are very grateful for the support of @cnrs.fr and #Infranalytics that allows us to access the 1.2 GHz spectrometer in Lille for free (upon selection of proposals of course).
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Nicholas Fitzkee @fitzkeelab.bsky.social · 14/05/2025
Anyone have a lead on replacement syringes for Malvern VP-ITC instruments? They no longer sell them, and they want me to upgrade to the PEAQ system. Unfortunately, we have a PEAQ-ITC, and it doesn't work with the concentrations needed for nanoparticle experiments. #chemsky #biophysics #ITC
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Kevin Gardner @nmrkaygee.bsky.social · 14/05/2025
Basic science saves lives and fuels the economy, which is why I’m advocating for: ➡️NIH & NSF to spend FY25 funds ➡️$51.3B for NIH, $9.9B in FY26 ➡️Restoration of many canceled NIH & NSF grants Act now. Contact your lawmakers today: asbmb.quorum.us/campaign/123.... #ScienceServesUsAll #ASBMBAdvocates
asbmb.quorum.us
Urge Congress to re-establish the U.S. as the Leader in Innovation
American Society For Biochemistry And Molecular Biology
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Drug Monkey @drugmonkey.bsky.social · 09/05/2025
No-cost extensions of NIH grants are no longer automatically approved drugmonkey.wordpress.com/2025/05/09/n...
drugmonkey.wordpress.com
No-cost extensions of NIH grants are no longer automatically approved
The no-cost extension (NCE) allows the recipient of a NIH grant to continue to spend on the project after the original award interval has expired. This NIH website explains the way NCE used to work…
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Derek Lowe @dereklowe.bsky.social · 09/05/2025
Heavy water isn’t water. That goes for protein NMR experiments and for a lot else besides:
science.org
Heavy Water in Your NMR Experiments, And Elsewhere
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Vanderbilt Center for Structural Biology @vanderbiltcsb.bsky.social · 11/04/2025
Here @cameronicohen.bsky.social dives into the new findings from the @dougkojetin.bsky.social & the John Yang labs ... "From activation to repression: decoding the impact of PPARγ ligands on ligand-binding domain conformation" bit.ly/43P7xJG @vubasicsciences.bsky.social @vanderbilt.edu
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boehninglab @boehninglab.com · 02/05/2025
NIH adds about 100 billion/yr to the economy
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boehninglab @boehninglab.com · 02/05/2025
Budget released today: 40% cut to NIH 50% cut to NSF If enacted, this will destroy academic research in the United States. It will also have a major trickle down effect on the entire academic ecosystem
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Dylan Burnette @mag2art.bsky.social · 28/04/2025
Burnette lab graduate student, Zach Sanchez, won the Steve Hann Outstanding Graduate Student Award! He then gave a fun talk on blebbisomes! You can read about his work here: nature.com/articles/s41... @vubasicsciences.bsky.social
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Jeremy Berg @jeremymberg.bsky.social · 27/04/2025
TV watching recommendations The lead story on 60 Minutes tonight is about NIH and concerns about damage done and continuing during the current administration. 1/2
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Doug Kojetin @dougkojetin.bsky.social · 25/04/2025
Looking forward to digging into this new @natchembio.nature.com review article by my colleague @stephanieaw.bsky.social (and @fraserlab.com)! @vanderbilt.edu @vumedicine.bsky.social @vanderbiltcsb.bsky.social pubmed.ncbi.nlm.nih.gov/40275100/
pubmed.ncbi.nlm.nih.gov
Advances in uncovering the mechanisms of macromolecular conformational entropy - PubMed
During protein folding, proteins transition from a disordered polymer into a globular structure, markedly decreasing their conformational degrees of freedom, leading to a substantial reduction in entr...
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ML for Protein Engineering Seminar @ml4proteins.bsky.social · 22/04/2025
Next Tues (4/29) at **4:30PM** ET, we will have @ginaelnesr.bsky.social @hkws.bsky.social present "Learning millisecond protein dynamics from what is missing in NMR spectra" Paper: biorxiv.org/content/10.1... Sign up on our website for zoom links!
biorxiv.org
Learning millisecond protein dynamics from what is missing in NMR spectra
Many proteins’ biological functions rely on interconversions between multiple conformations occurring at micro-to millisecond (µs-ms) timescales. A lack of standardized, large-scale experimental data ...
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Jeremy Berg @jeremymberg.bsky.social · 20/04/2025
Some new language appeared in the HHS Grants Policy Statement last week. It doesn't apply to NIH grants (yet) 1/n
media.tenor.com
a man is sitting at a table in a kitchen with the words ermah-gerd written on the screen behind him .
ALT: a man is sitting at a table in a kitchen with the words ermah-gerd written on the screen behind him .
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Ardem Patapoutian @ardemp.bskyverified.social · 20/04/2025
In science, we don’t give negative data nearly enough love. Showing with genetic precision that CGRP and Substance P aren’t needed for different kinds of acute and chronic pain? That’s huge.
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Matt Sikora @mjsikora.bsky.social · 20/04/2025
Peer networks are so important. We built @nrimpact.bsky.social for this reason, and while we did not anticipate *waves hands wildly* when we put the group together in 2019, the 46 faculty in our group lean on each other in times of personal and professional challenges. www.nrimpact.com
nrimpact.com
NR IMPACT
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Vanderbilt School of Medicine Basic Sciences @vubasicsciences.bsky.social · 18/04/2025
Congrats to Kelly O’Rourke, the Department of Biochemistry's Trainee of the Month! 👏🏾👏👏🏻👏🏽 Kelly works in the lab of @dougkojetin.bsky.social and her advice for other students Make self-care a priority. "When I have balance in other areas of my life, I feel more productive and motivated in the lab."
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Stephanie Wankowicz @stephanieaw.bsky.social · 15/04/2025
The Tortured Proteins Department Esp. 2 with @fraserlab.bsky.social is out! In addition to bantering about the craziness of the times, we chat about some recent exciting preprints (see links below). open.spotify.com/show/10PHVou...
creators.spotify.com
Episode 2: Cool Science Among Continued Uncertainty by The Tortured Proteins Department
We chatted about the continued chaos of science infrastructure and dived into some cool science from recent meetings Jaime and Stephanie attended. We introduce two new segments: preprints and how to d...
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Stephanie Wankowicz @stephanieaw.bsky.social · 31/03/2025
Join us for the 2nd Macromolecular Conformational Ensembles Conference on June 9th/10th at UCSF. The most compelling questions in structural biology cannot be effectively addressed using only a single structure. conformationalensembles.github.io @fraserlab.bsky.social
conformationalensembles.github.io
Conformational Ensemble
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Vanderbilt Center for Structural Biology @vanderbiltcsb.bsky.social · 07/04/2025
⚓️It's VU Giving Week! Support the CSB and the Anne Karpay Award in Structural Biology! Your gift supports innovation and discovery across Vanderbilt. Every gift makes a difference! 🧪🔬 Give to the CSB: www.givecampus.com/campaigns/57... Give to the Karpay Award: www.givecampus.com/campaigns/57...
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Jeremy Baskin @jeremybaskin.bsky.social · 03/04/2025
Groundbreaking study in Cell from @leventallab.bsky.social: phospholipid asymmetry is a defining feature of the plasma membrane and cholesterol fills the holes — major implications for how this membrane works. A #lipidtime must-read! www.cell.com/cell/abstrac...
cell.com
Cell membranes sustain phospholipid imbalance via cholesterol asymmetry
This work challenges a major assumption in cell biology by showing that lipid bilayers can have drastically different phospholipid abundances between their two leaflets. This lipid abundance asymmetry...
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Doug Kojetin @dougkojetin.bsky.social · 30/03/2025
Sunday morning elliptical workout entertainment thanks to @stephanieaw.bsky.social @fraserlab.bsky.social
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Biology Open @biologyopen.bsky.social · 25/03/2025
We are excited to be launching the next phase of our Fast & Fair peer review initiative: offering high-quality peer review within 7 working days. #fastandfairpeerreview Read the Editorial by EiC Daniel Gorelick @danielgorelick.bsky.social at: bit.ly/4kYD1mL
Fast & Fair peer review

A new initiative offering high-quality peer review within 7 working days of submission

Biology Open
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Doug Kojetin @dougkojetin.bsky.social · 25/03/2025
Fast, fair, and PAID peer review! WTG @danielgorelick.bsky.social 🙌
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Doug Kojetin @dougkojetin.bsky.social · 20/03/2025
…and treatments for bladder cancer!
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Katrin Karbstein Lab @kkarbstein.bsky.social · 14/03/2025
RNA2025 will feature long talks by: Jennifer Doudna David Tollervey Ling-Ling Chen Matt Disney Tracy Johnson Erin Schuman And 151(!!!) high quality additional talks. Great engagement at poster sessions. Many prizes. Stay at the conference site. Be there or be square!
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Doug Kojetin @dougkojetin.bsky.social · 28/02/2025
Now published! Read our newest story! doi.org/10.1038/s414...
doi.org
Ligand efficacy shifts a nuclear receptor conformational ensemble between transcriptionally active and repressive states - Nature Communications
PPARγ nuclear receptor ligand activities can span agonism to inverse agonism. Here, the authors use NMR to show how chemical changes within a ligand series shift the receptor’s dynamic conformational ...
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Jeremy Berg @jeremymberg.bsky.social · 26/02/2025
ATTENTION The Washington Post is collecting data about funding issues. Please consider contributing. thewashingtonpost.formstack.com/forms/scient...
thewashingtonpost.formstack.com
Are you a scientist who has lost funding or grants in recent weeks? - Formstack
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Katie Sandlin @kmsandlin.bsky.social · 14/02/2025
I maxed out my credit card, emptied my savings account, and took out a loan to move from Alabama to Bethesda, MD. I don’t even qualify for unemployment since I’ve only worked at NIH for a month. I will be financially and medically devastated. Seeking suggestions for anywhere that’s hiring!!
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Ardem Patapoutian @ardemp.bskyverified.social · 13/02/2025
😳🤯. Dr. Laurer was the coauthor of the memo yesterday acknowledging that the NIH funding freeze was illegal and directing staff to resume issuing grants.
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Daniel Gorelick @danielgorelick.bsky.social · 11/02/2025
We need one of these for our lab
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 10/02/2025
This is an amazing achievement - angstrom scale imagine of glycan molecules, what a great time for #glycotime. Congrats Leonhard Möckl! www.biorxiv.org/content/10.1...
biorxiv.org
Angstrom-resolution imaging of cell-surface glycans
Glycobiology is rooted in the study of monosaccharides, Angstrom-sized molecules that are the building blocks of intricate glycosylation patterns. Glycosylated biomolecules form the glycocalyx, a dens...
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Doug Kojetin @dougkojetin.bsky.social · 10/02/2025
Application deadline extended to Feb 14, 2025! Do you know any undergraduate students interested in structural biology? Check out this summer program at Meharry Medical College in Nashville TN!
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Daniel Gorelick @danielgorelick.bsky.social · 10/02/2025
Trainees who applied for an NIH diversity fellowship whose applications were withdrawn/not being reviewed, there's a NYTimes reporter who wants to talk, especially interested in applicants with disabilities. DM me & I'll put you in touch, will keep all contact confidential. Please amplify
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 09/02/2025
Cool paper using LLM to discover a protein sequence code for subcellular localization 👏 www.science.org/doi/10.1126/...
science.org
Protein codes promote selective subcellular compartmentalization
Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...
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Sri Kosuri @srikosuri.bsky.social · 08/02/2025
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
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John Streicher @johnstreicher.bsky.social · 08/02/2025
Hey all, I know it’s a sewer, but the main action and fight on the NIH is over on Twitter. We could use your voice. I’ve already been contacted by reporters based on posts over there, it’s your best chance to be heard.
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Tim Clancy @viewfromarchstreet.com · 08/02/2025
On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-24-110: Notice of Legislative Mandates in Effect for FY 2024
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Legislative Mandates in Effect for FY 2024 NOT-OD-24-110. NIH
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Carl T. Bergstrom @carlbergstrom.com · 07/02/2025
White House budget proposal may slash NSF funding from 9 billion to 3 billion a year.
arstechnica.com
White House budget proposal could shatter the National Science Foundation
“This kind of cut would kill American science and boost China.”…
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Doug Kojetin @dougkojetin.bsky.social · 06/02/2025
Not #nuclearreceptors
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