Heat shock protein 70 (Hsp70) is a molecular chaperone that plays a key role in cellular processes by assisting protein folding and preventing aggregation. During client-protein folding, Hsp70…

Fibrinogen plays a central role in the physiological processes of blood coagulation and, unfortunately, ischemic stroke, where it is routinely exposed to mechanical forces. In this study, we employed…

In vivo chemical cross-linking combined with mass spectrometry analysis (XL-MS) enables the direct capture of protein-protein interactions (PPIs) within their native cellular environment. This…

RyR2 channels regulate Ca2+ release from the sarcoplasmic reticulum (SR), the Ca storage organelle in cardiac muscle. Altered RyR2 activity is a key factor promoting atrial and ventricular…

Protein function-conditioned generative modeling can unify two core goals in protein engineering: predicting the effects of sequence variants and designing new sequences that satisfy functional…

Biomolecular condensates formed by phase separation inside cells often exhibit viscoelastic behavior, yet their shape recovery and fusion dynamics are frequently interpreted using purely viscous…

Deciphering the mechanisms of protein-protein interactions (PPIs) and protein structural changes within the native cellular environment is crucial for advancing drug discovery. In vivo chemical…

The NBAR-domain-containing protein endophilin, a major player in many endocytic pathways, has offered considerable insight into Bin/amphiphysin/Rvs (BAR)-domain-driven membrane remodeling. However,…

Macromolecules, such as proteins, antibodies, nanobodies, and other affinity binders, play essential roles in therapeutic and diagnostic applications due to their high specificity and functionality.…

Human skin wound healing is a complex process of tissue pattern formation driven by massive cell migration and regeneration, coordinated through intercellular communication. A multiscale tissue…

Traditionally, cells have been classified by their type. Identifying cell types was deemed vital for understanding their biological processes. More recently, cell-type classification has been…

The bacterial flagellar motor drives cell motility by rotating the flagellar filament and converting ion flux into mechanical work. At low counterclockwise (CCW) rotational speeds, the motor operates…

Histones provide one of biology’s most familiar solutions to the problem of organizing DNA. In eukaryotes, DNA wraps around histone proteins to form nucleosomes, creating the basic structural unit of ...

Peer Review Week (PRW) is a global celebration of the vital role peer review plays in ensuring the quality and integrity of research.

Red blood cell (RBC) deformability is critical for in vivo tissue oxygenation and has been studied in ideal, canonical flows. In vitro frameworks are needed to study RBC deformation in more complex…

In our research, we have combined theoretical modeling with confocal fluorescence microscopy to study podosomes, small, actin-rich structures that immune cells use to contact, probe, and remodel the b...