The ciliary transition zone (TZ) regulates ciliary proteome composition, yet its molecular architecture, protein content, and contribution to motile ciliopathies remain poorly defined. We applied in situ cryo-electron tomography and subtomogram averaging ...

MemBrain v2 enables streamlined analysis of membranes in cryo-electron tomography by providing user-friendly tools for membrane segmentation, membrane protein localization and spatial analysis, suppor...

Epithelial cells remodel their shape during phagocytosis while preserving tissue cohesion. Here, authors show that the E-cadherin/catenin adhesion complex is repurposed at phagocytic contacts, where i...

Published in Nucleus (Vol. 17, No. 1, 2026)

Science sleuth’s findings raise questions for researchers working to improve the reliability of commercial antibodies.

Chromatin organizes nuclear DNA, but whether it actively regulates whole-cell mechanics remains unknown. Here, we used NETosis to show that chromatin decompaction within the nucleus increases plasma membrane tension and cell volume, establishing chromatin as a regulator of cell mechanics.

Proponents argue that the current system creates a false sense of precision, but critics fear that the change could increase political interference.

Bhaskar Naidu and Vera Lillo et al. show that extracellular mechanical forces reciprocally regulate Golgi function. By linking cell adhesion and spreading,

Retirement symposium honoring Dr. James R. Sellers’ contributions to myosin studies. Leading scientists in the field will be present.

This study identifies the cardiac protein Leiomodin 2 as an actin filament polymerase that enables growth from filament pointed ends, revealing how muscle actin filament length is controlled and how L...

Cells mechanically interface with their surroundings through the actin cytoskeleton, a network of dynamic actin filaments, force-generating myosin motor proteins, and hundreds of associated binding pr...

ALT: Huh Kermit

Highlighted Article: MyoF regulates actin organization in T. gondii by assembling into an oligomeric complex that contains multiple motor domains.

Cells mechanically interface with their surroundings through the actin cytoskeleton, a network of dynamic actin filaments, force-generating myosin motor proteins, and hundreds of associated binding pr...

Dr. Thomas D. Pollard's work transformed cytoskeleton research into a quantitative, mechanistic science. Over five decades, he established core principles of actin dynamics, including filament polari...

La Jolla, California—April 29, 2026—The J. Craig Venter Institute (JCVI) announced that J. Craig Venter, Ph.D., the Institute’s founder, board...

Structural studies demonstrate that myosin generates forces that cause structural changes in actin, modulating cooperative binding by α-catenin and thus signal transduction and intercellular communication via adhesion complexes.

Structural studies demonstrate that myosin generates forces that cause structural changes in actin, modulating cooperative binding by α-catenin and thus signal transduction and intercellular communica...