iiinova — where your digital self keeps evolving

Joyce Meiring @joycemeiri.bsky.social · 24/09/2026

Excited to share that our latest story on #microtubule conformation controlling cell #signaling is now out in NCB! We show that microtubule expansion by taxane chemotherapeutics releases microtubule bound GEF-H1 which in turn activates RhoA/ROCK signaling. ✨ www.nature.com/articles/s41...

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Joyce Meiring @joycemeiri.bsky.social · 19/03/2026

What is the public opinion on color coding treatments in figures and then using the same colors used in the graph to outline matching representative images? Is it useful or am I being too extra?

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Joyce Meiring @joycemeiri.bsky.social · 09/03/2026

I collaborated with Peter Friedl's team, @jpassmore.bsky.social and @ekatrukha.bsky.social to make this short video on cancer cell invasion. Check it out! youtu.be/EH4vgUfr1jI?...

youtu.be

Invasion and Metastasis - How cancer cells become invasive

YouTube video by IMAGINE! microscopy

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Joyce Meiring @joycemeiri.bsky.social · 29/01/2026

Good morning to everyone except people who write "as described previously" in their paper and then cite another paper that doesn't describe the procedure. 🫠

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Biomedical Picture of the Day BPoD @bpodaily.bsky.social · 21/01/2026

Tools to optically & chemically manoeuvre cytoskeleton structures intermediate filaments reveal their characteristics & interactions 📷 Milena Pasolli & @joycemeiri.bsky.social et al @utrechtuniversity.bsky.social in @jcb.org ➡️ bpod.org.uk/archive/2026... with @antdlewis.bsky.social

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Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 05/01/2026

If you have time tomorrow, join my online talk about LLS/single molecule/microtubules and 3D data at @bioimagingna.bsky.social user group (18:00 CET for Europe). I hope I manage to fit 25 movies into 20 cohesive slides and connection will be ok.

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Joyce Meiring @joycemeiri.bsky.social · 31/12/2025

Thanks for highlighting our most recent preprint 😊

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bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 23/12/2025

Taxane-Induced Conformational Changes in the Microtubule Lattice Activate GEF-H1-Dependent RhoA Signaling www.biorxiv.org/content/10.64898/20…

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Joyce Meiring @joycemeiri.bsky.social · 24/12/2025

Bored over the holidays? Give our new preprint on how #microtubule lattice alteration by taxols can regulate #RhoA #signalling via GEF-H1 a read! Perhaps a new mechanism of action for taxol #chemotherapeutics during interphase. www.biorxiv.org/content/10.6... Happy holidays ✨🎄

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Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 19/09/2025

A cell finding its way through the matrix, imaged with @joycemeiri.bsky.social on LLS.

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Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 05/09/2025

Our new preprint is about the airway epithelium microtubule network, cilia, basal body protein composition, averaging of volumetric fluorescence data, and expansion microscopy. Four years of very hard work from our very talented Emma van Grinsven. www.biorxiv.org/content/10.1... (1/N)

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Journal of Cell Biology @jcb.org · 01/09/2025

Our September issue is here! rupress.org/jcb/issue/22... Airyscan super-resolution immunofluorescence image of HeLa cells stained for two types of intermediate filaments: vimentin (magenta) & keratin-8 (cyan). From Pasolli, @joycemeiri.bsky.social, Akhmanova et al. rupress.org/jcb/article/...

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Joyce Meiring @joycemeiri.bsky.social · 08/08/2025

All the opto-vimentin plasmids are now available on Addgene: www.addgene.org/Anna_Akhmano...

addgene.org

Addgene: Anna Akhmanova Lab Materials

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Joyce Meiring @joycemeiri.bsky.social · 18/07/2025

Radial microtubules in cyan and non-radial microtubules in yellow.

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Journal of Cell Biology @jcb.org · 15/07/2025

Optogenetic and chemical genetic tools for rapid repositioning of #vimentin intermediate filaments. New tools developed by Milena Pasolli, Joyce Meiring @joycemeiri.bsky.social, Anna Akhmanova and colleagues @utrechtuniversity.bsky.social: rupress.org/jcb/article/... @gijsjekoenderink.bsky.social

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Journal of Cell Biology @jcb.org · 08/07/2025

New: Pasolli, Meiring, Akhmanova et al. @utrechtuniversity.bsky.social describe tools to acutely relocate #vimentin intermediate filaments by inducibly coupling them to microtubule motors. rupress.org/jcb/article/... @joycemeiri.bsky.social @gijsjekoenderink.bsky.social #Technology #Cytoskeleton

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Joyce Meiring @joycemeiri.bsky.social · 08/07/2025

Excited to share that our fast & reversible chemical and optogenetic vimentin pulling tools are now published in JCB! 🥳 We show a subset of organelles are displaced with vimentin pulling to the cell centre and cells become much softer despite little or no effect on actin/MTs doi.org/10.1083/jcb....

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corrylab.bsky.social @corrylab.bsky.social · 16/03/2025

Thrilled to share our latest preprint from @yiechanglin.bsky.social & @ciarawallis.bsky.social showing that AF2-Multimer and AF3 can quickly & accurately predict the oligomeric states & structures of proteins (& maybe can identify multiple biologically relevant oligomeric states 👀) tiny.cc/oligomers

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Joyce Meiring @joycemeiri.bsky.social · 07/03/2025

Don't forget to register, abstract submission deadline is next week March 14. 😉

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Joyce Meiring @joycemeiri.bsky.social · 19/02/2025

Is this an animated Jackson Pollock painting or live cell tracking movie? 😍

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Joyce Meiring @joycemeiri.bsky.social · 29/01/2025

Come join us in Utrecht for some cutting edge #microscopy and 3D cell biology!! #3Dcellbio

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Joyce Meiring @joycemeiri.bsky.social · 27/11/2024

Hi! I was wondering if anyone had successfully cultured happy HEK293T cells in defined serum alternatives? If so, what did you use?

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Joyce Meiring @joycemeiri.bsky.social · 22/11/2024

Excited to share our new pre-print showcasing tools (chemical & optogenetic) for repositioning Vimentin in cells! Movie shows ER (Halo-KDEL) sheets being relocalized together with vimentin (Vim) upon local vimentin pulling in U2OS. @gijsjekoenderink.bsky.social www.biorxiv.org/content/10.1...

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Christophe 🔬 Leterrier @christlet.bsky.social · 21/11/2024

Time to shine for intermediate filaments! An optogenetic vimentin perturbation strategy reveals its role for ER and mitochondria positioning (but no effect on actin or microtubules patterns) @joycemeiri.bsky.social www.biorxiv.org/content/10.1...

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Joyce Meiring @joycemeiri.bsky.social · 20/11/2024

CAMSAP3 stretches (microtubule -end binding protein) are shown in yellow. They move towards the Soma in developing neurons.

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Joyce Meiring @joycemeiri.bsky.social · 19/11/2024

Hi! My name is Joyce and I love building and using tools to manipulate the #cytoskeleton of cells to better understand their function. 🔬 Below you can see my movie of #opto-katanin ✂️(SspB-mCh-p60) being used to locally disassemble #microtubules (labelled by SiR-tubulin) inside a neuron.

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