Science sleuth’s findings raise questions for researchers working to improve the reliability of commercial antibodies.

The purpose of this phase of our engagement has not been to make or announce decisions. It has been to build a shared understanding of the pressures facing the system and to hear from applicants, reviewers and institutions on possible interventions and their implications.

Jha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration.

Verification of 50 years of data bolsters immunology research, but identifies “suspicious” papers that don’t hold up

Conway et al. show that integrin β1 phosphorylation is regulated through balanced activities of tyrosine kinases, such as Src and Arg, and phosphatases, such as PTP-PEST and Shp2, facilitating invadop...

T cell priming is characterized by an initial activation phase that involves stable interactions with dendritic cells (DCs). How activated T cells receive the paracrine signals required for their diff...

"I know that I am making the right decision because whenever I think about changing my gender role, I am flooded with feelings of relief."

Cell biology; Organizational aspects of cell biology; Specialized functions of cells; Functional aspects of cell biology

Cell migration is crucial for development and tissue homeostasis, while its dysregulation leads to severe pathologies. Cell migration is driven by the extension of actin–based lamellipodia protrusions...

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YouTube video by Marine Biological Laboratory

B cells have been shown to be phagocytic under some circumstances. However, the phagocytic capacity of different B cell subsets and how this is linked to Antigen (Ag) presentation or other functions h...

CD47 is expressed by viable cells to protect against phagocytosis. CD47 is recognized by SIRPα, an inhibitory receptor expressed by macrophages and other myeloid cells. Activated SIRPα recruits SHP-1 ...