iiinova — where your digital self keeps evolving

ImmunoSketch @actuallypublished.bsky.social · 31/12/2024

This concludes our 10-day journey and the ImmunoSketch adventure. Thank you for joining in. May your new year be as resilient and adaptive as the cells we study. Happy new year! 🎄

ImmunoSketch @actuallypublished.bsky.social · 31/12/2024

And for the grand finale: Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity. A perfect reminder of immunology’s complexity—how one decision can shape an entire fate.

ImmunoSketch @actuallypublished.bsky.social · 30/12/2024

Day -2 highlights an immune-sensory dialogue: A γδ T cell–IL-3 axis controls allergic responses through sensory neurons. Immunology doesn’t just fight disease—it listens, connects, and responds. A beautiful symphony of cells to close out the year.

ImmunoSketch @actuallypublished.bsky.social · 29/12/2024

On day -3, we spotlight adaptation: Immune system adaptation during gender-affirming testosterone treatment. A testament to the immune system’s flexibility and resilience—much like the spirit we carry into the new year.

ImmunoSketch @actuallypublished.bsky.social · 28/12/2024

Day -4 turns our focus to early development: Proteome asymmetry in mouse and human embryos before fate specification. A fascinating reminder that immune-related pathways often begin shaping outcomes before fate is even sealed.

ImmunoSketch @actuallypublished.bsky.social · 27/12/2024

On day -5, we celebrate immune cells in regeneration: Dynamic roles of ILC3 in endometrial repair and regeneration. Just like the new year brings fresh beginnings, ILC3s show us how the immune system fosters repair and renewal.

ImmunoSketch @actuallypublished.bsky.social · 26/12/2024

Day -6 dives into the mechanics of cell death: Septins promote macrophage pyroptosis. Who knew cell death pathways could bring such dramatic energy to the immunology stage?

120

ImmunoSketch @actuallypublished.bsky.social · 25/12/2024

Day -7 brings us a lesson in perfect timing: Lung-resident alveolar macrophages regulate the timing of breast cancer metastasis. A reminder that, like the holiday season, the immune system knows when to act—and when to wait.

ImmunoSketch @actuallypublished.bsky.social · 24/12/2024

Day -8 shines a light on nature’s microscopic defense systems: Gamma-Mobile-Trio systems are mobile elements rich in bacterial defensive and offensive tools. Like an immune system stocking stuffer, these mobile elements carry all the surprises—tools for attack and defense.

ImmunoSketch @actuallypublished.bsky.social · 23/12/2024

On day -9 of our year-end countdown, we celebrate immune engineering at its finest: A tetraspecific engager armed with a non-alpha IL-2 variant harnesses NK cells against B cell NHL. Natural killer cells armed and ready—it’s immunology’s version of Santa’s sleigh delivering precision medicine.

140

ImmunoSketch @actuallypublished.bsky.social · 22/12/2024

Day -10: Today’s highlight takes us to the liver: Kupffer cell reverse migration into liver sinusoids mitigates neonatal sepsis and meningitis. Proof that even immune cells can come home for the holidays—and do remarkable things when they get there.

ImmunoSketch @actuallypublished.bsky.social · 22/12/2024

After six months, the ImmunoSketch project has officially reached its end. The goal? To take our intricate, jargon-heavy science and turn it into something your loved ones might finally understand—so they stop assuming you just “look at cells” all day.

240

ImmunoSketch @actuallypublished.bsky.social · 21/12/2024

CAR-T cells aim to hit cancer targets, but when the target’s unclear, treatment struggles to succeed. @freemanlciaraMD @DrFredLocke @bloodjournal.bsky.social t.co/bPTq2SJzx8 #ImmunoSky 🧪

ImmunoSketch @actuallypublished.bsky.social · 21/12/2024

Scientists turned a harmless skin bacterium into a powerful vaccine delivery tool, boosting immunity in the lungs and nose. @mfgrp.bsky.social @djenetbousbaine.bsky.social @nature.com t.co/xXXCJx5VYm #ImmunoSky 🧪

0134

ImmunoSketch @actuallypublished.bsky.social · 21/12/2024

Some immune cells fuel the fire of disease, while others help put it out—finding the balance could change treatments. @juliosds1.bsky.social t.co/8HpBNRQ9Wv #ImmunoSky 🧪

051

ImmunoSketch @actuallypublished.bsky.social · 19/12/2024

Tracking bacterial ‘seeds’ in new soil reveals how they grow, adapt, and pave the way for next-gen microbiome therapies. @gangfang.bsky.social @biorxivpreprint.bsky.social t.co/QisGjqmInv #ImmunoSky 🧪

032

ImmunoSketch @actuallypublished.bsky.social · 17/12/2024

Unlocking how bacteria form tiny clusters like marbles could lead to better cystic fibrosis treatments. @DarchLab @AlexaGannon @usouthflorida.bsky.social t.co/L3Af0Z7nQp #ImmunoSky 🧪

ImmunoSketch @actuallypublished.bsky.social · 17/12/2024

Think of a conductor guiding an orchestra—scientists discovered how T cells fine-tune their responses to keep the immune system in harmony. @MarsonLab @KroganLab @jkpritch.bsky.social @natureportfolio.bsky.social @gladstoneinst.bsky.social t.co/VeyYIs40LM #ImmunoSky 🧪

ImmunoSketch @actuallypublished.bsky.social · 17/12/2024

Neutrophils cast chromatin nets to trap tuberculosis, but these nets also feed the bacteria, fueling the disease. @stallingslab.bsky.social @cellpress.bsky.social t.co/RGDWLHnvJP #ImmunoSky 🧪

080

ImmunoSketch @actuallypublished.bsky.social · 17/12/2024

CCDC134 is the immune system's mailroom supervisor, sorting and delivering critical defense signals to keep us protected. @rebsamenlab.bsky.social @lbernaleau.bsky.social @jexpmed.bsky.social @unil.bsky.social t.co/CikWuMuPCx #ImmunoSky 🧪

000

ImmunoSketch @actuallypublished.bsky.social · 17/12/2024

Cancer treatments can jam immune signals, raising heart risks—scientists chart a path to smoother strategies. @ChiaraGiannare1 @kathrynmoorelab @natureportfolio.bsky.social t.co/lPkYiK4Kdw #ImmunoSky 🧪

000

ImmunoSketch @actuallypublished.bsky.social · 11/12/2024

Got an immuno paper in mind that deserves the pencil-sketch summary? Drop your picks below! #ImmunoSky 🧪 #Immunology #SciComm

ImmunoSketch @actuallypublished.bsky.social · 11/12/2024

Imagine cells bursting into tiny fireworks to alert the immune system and spark a powerful defense. @carolinelholley.bsky.social @inflammasomelab.bsky.social @jkagan.bsky.social @samstehbens.bsky.social @doktrnick.bsky.social t.co/dE9wPARavh #ImmunoSky 🧪

0125

ImmunoSketch @actuallypublished.bsky.social · 10/12/2024

Boosting your body's bees with D-mannose keeps them buzzing against cancer. @Guideng4 @SuYapeng @cellpress.bsky.social @fredhutch.bsky.social t.co/LIvPi24fjl #ImmunoSky 🧪

ImmunoSketch @actuallypublished.bsky.social · 10/12/2024

Scientists have unlocked a new way to tinker with our genes, like having a keyring that can open or close almost any lock in our bodies. @AdrianoAguzzi @lucaspelkmans.bsky.social @MartinUCSF @natureportfolio.bsky.social t.co/HXs7ocrpyV #ImmunoSky 🧪

ImmunoSketch @actuallypublished.bsky.social · 07/12/2024

Unlocking the secrets of our immune system is like discovering hidden treasures in a library, where each book holds the key to better health. @pmeysman.bsky.social @cziscience.bsky.social www.science.org/doi/10.1126/... #ImmunoSky 🧪

041

ImmunoSketch @actuallypublished.bsky.social · 06/12/2024

When bacteria learn to resist one antibiotic, it's like learning a language, making similar ones easier but others harder to master. @typaslab.bsky.social @nazgulsakenova.bsky.social @embl.org @naturemicrobiol.bsky.social t.co/y8Vc2LNHwY #ImmunoSky 🧪

ImmunoSketch @actuallypublished.bsky.social · 05/12/2024

HIV hides in protective "cocoons" within cells, staying infectious for weeks and evading drug treatments, but destroying these cocoons stops the virus. @di-nunzio-lab.bsky.social @pasteur.fr @embojournal.bsky.social @embopress.org www.embopress.org/doi/full/10.... #ImmunoSky 🧪

052

ImmunoSketch @actuallypublished.bsky.social · 04/12/2024

Like a photographer choosing between quick snapshots or careful portraits, our immune system balances fast action and precise antibody creation. @profshanecrotty @katyely.bsky.social @johnmlindner.bsky.social @cellpress.bsky.social @emoryuniversity.bsky.social t.co/E2WUBinqCd #ImmunoSky 🧪

172

ImmunoSketch @actuallypublished.bsky.social · 04/12/2024

A starter pack for PhD students and Postdocs in Immunology to connect 🔽 Drop a 🧬 and I'll add you to the list. Let's build the upcoming immuno community! #ImmunoSky 🧪 go.bsky.app/RABVXY4

799758

ImmunoSketch @actuallypublished.bsky.social · 03/12/2024

Even after COVID-19 clears, parts of the virus can linger in the brain like a song stuck on repeat, causing lasting symptoms. @erturklab.bsky.social @markuselsner.bsky.social @harsharanbhatia.bsky.social @faridahellal.bsky.social @tumuenchen.bsky.social t.co/ExdcGIhM3Q #ImmunoSky 🧪

ImmunoSketch @actuallypublished.bsky.social · 02/12/2024

Scientists have designed tiny, magnetic-like proteins that target and fight diseased cells while leaving healthy ones alone, paving the way for new treatments. @BingxuL @jBonzaniniSci @amotmaen.bsky.social @thearmita.bsky.social @uwproteindesign.bsky.social t.co/r6FkQMW1Qt #ImmunoSky 🧪

000

ImmunoSketch @actuallypublished.bsky.social · 01/12/2024

Imagine your body as a coral reef where cancer causes pollution, but scientists found a way to remedy it. @obenaufa.bsky.social @guillemxtivill.bsky.social @impvienna.bsky.social @natureportfolio.bsky.social t.co/tySfh9MXSq #ImmunoSky 🧪

041

ImmunoSketch @actuallypublished.bsky.social · 01/12/2024

Your body is a computer network, and when 'glitches' like infections hit your joints, tiny 'firewalls' jump into action to protect them. @tetsuohasegawa.bsky.social @natimmunol.bsky.social @mrclmb.bsky.social t.co/gN8TmEUleb #ImmunoSky 🧪

ImmunoSketch @actuallypublished.bsky.social · 30/11/2024

When the immune system's post office can't sort its packages, infections take over. @bernhard-ransmayr.bsky.social @boztugk.bsky.social @stanna-ccri.bsky.social t.co/cXnBiZt094 #ImmunoSky 🧪

ImmunoSketch @actuallypublished.bsky.social · 28/11/2024

Scientists are unlocking the secrets of how bacterial forests thrive and adapt, paving the way for strategies to outsmart their defenses. @KielianLab @LKorshoj @unmc.bsky.social @naturecomms.bsky.social t.co/b1ZGgYlab0 #ImmunoSky 🧪

ImmunoSketch @actuallypublished.bsky.social · 27/11/2024

Think of immune cells as searchers in a maze, finding and fighting cancer with the help of new treatments. @hoheyn @AvgustinovaLab @biorxiv-immuno.bsky.social t.co/pso2rGIODD #ImmunoSky 🧪

000

ImmunoSketch @actuallypublished.bsky.social · 26/11/2024

When our body's editor misses a beat, tiny helpers step in to keep our immune system from overreacting. @jackiheraudfarlow.bsky.social @alistairchalk.bsky.social t.co/F3Hc5A2rWw #ImmunoSky 🧪

031

ImmunoSketch @actuallypublished.bsky.social · 25/11/2024

Imagine if your gut's repair crew goes rogue—that's how unchecked cell growth can lead to serious issues like cancer. @srudas.bsky.social @martinaparigi.bsky.social @ejvillablanca.bsky.social @natureportfolio.bsky.social t.co/nyAZwPx1GM #ImmunoSky 🧪

000

ImmunoSketch @actuallypublished.bsky.social · 25/11/2024

A sneaky Zika virus tricks a helpful protein to copy its blueprints, but struggles without its unwitting accomplice. @ChatelChaixLab @ScaturroLab @viralcell @trushar7.bsky.social @elife.bsky.social t.co/7lck8pVTM0 #ImmunoSky 🧪

000

ImmunoSketch @actuallypublished.bsky.social · 23/11/2024

Imagine your immune system as a dance troupe, where NK cells act like choreographers to keep the harmony, especially after transplants. @sarahcrome.bsky.social t.co/91JDhHrFDp #ImmunoSky 🧪

ImmunoSketch @actuallypublished.bsky.social · 22/11/2024

Imagine a tiny gardener helping viruses escape from cells by trimming away tangled vines. @pasteur.fr @TMDCLab_Pasteur @Virus_Immunity t.co/O61C7zMUHq #ImmunoSky 🧪

040

ImmunoSketch @actuallypublished.bsky.social · 21/11/2024

Scientists have invented a new "GPS" that guides our body's own fighters to destroy blood cancer cells. @EricVivier1 @DemariaO @MorelYannis @immunoeditor.bsky.social t.co/LIPpsJjeSG #ImmunoSky 🧪

ImmunoSketch @actuallypublished.bsky.social · 20/11/2024

Scientists are tracking tiny "license plates" on our body's defense cells to reveal what's setting off the "burglar alarm" in our lungs. @wezisendama.bsky.social @richardchd.bsky.social @biorxiv-immuno.bsky.social www.biorxiv.org/content/10.1... #ImmunoSky 🧪

021

ImmunoSketch @actuallypublished.bsky.social · 19/11/2024

Scientists created a cellular "switch" that acts like a lock and key, precisely targeting cancer cells. @natureportfolio.bsky.social @piraner @KoleRoybal @Mohamad_Abedi @majo__duran www.nature.com/articles/s41... #ImmunoSky 🧪

163

ImmunoSketch @actuallypublished.bsky.social · 18/11/2024

Imagine your immune system as a beehive where cancer cells use smoke signals to confuse the NK worker bees. @jboettcherlab.bsky.social www.cell.com/cell-reports... #ImmunoSky 🧪