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Amir Motmaen

@amotmaen.bsky.social
167 followers 28 following 15 posts

Applications of AI for intelligent design of SynBio systems. MTS at Latent Labs. PhD at Baker Lab @UWproteindesign. MSc ETH Zurich and Frances Arnold. 🧑🏻‍🔬🔬🏳️‍🌈

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Reposted by Amir Motmaen
Alex Rubinsteyn @alexr.bsky.social · 15/07/2026
5.6 is good and Fable refuses to do bio Might pause my Claude subscription for a while
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Reposted by Amir Motmaen
Rob Patro @robp.bsky.social · 15/07/2026
It's not just bio in my experience; Fable is broadly useless for a large swath of reserach including CS theory, certain math, all bio (obviously), straight up SWE that touches any bio /security/other sensitive things, chemistry, etc. Fable is worse than 5.6 and even Opus, as it's basically absent.
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Reposted by Amir Motmaen
Alex Rubinsteyn @alexr.bsky.social · 21/11/2025
Hey @jamieheather.bsky.social what do you think of this? www.biorxiv.org/content/10.1...
biorxiv.org
Targeting peptide-MHC complexes with designed T cell receptors and antibodies
Class I major histocompatibility complexes (MHCs), expressed on the surface of all nucleated cells, present peptides derived from intracellular proteins for surveillance by T cells. The precise recogn...
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Reposted by Amir Motmaen
Nate Corley @ncorley.bsky.social · 15/08/2025
(1/7) Training biomolecular foundation models shouldn't be so hard. And open-source structure prediction is important. So today we're releasing two software packages: AtomWorks and RosettaFold3 (RF3) [www.biorxiv.org/content/10.1101/202…...)
biorxiv.org
Accelerating Biomolecular Modeling with AtomWorks and RF3
Deep learning methods trained on protein structure databases have revolutionized biomolecular structure prediction, but developing and training new models remains a considerable challenge. To facilita...
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Reposted by Amir Motmaen
Florian Praetorius @flopraetorius.bsky.social · 28/11/2023
The Praetorius lab for Biomolecular Design at the Institute of Science and Technology Austria (ISTA) is looking for grad students in 2024. If you are interested in protein design at a great institute near Vienna reach out to me! www.dropbox.com/scl/fi/6iny2...
dropbox.com
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Reposted by Amir Motmaen
Sergey Ovchinnikov @sokrypton.org · 16/11/2023
Late night experiment with @chrisfrank662.bsky.social :D The backbone designability test. Start w/ backbone (diffusion, hallucination), put a sequence on it (proteinmpnn, esm-if), then the final test is to make sure it folds back to the original structure (alphafold, omegafold, esmfold) (1/3)
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