iiinova — where your digital self keeps evolving

Wezi Sendama @wezisendama.bsky.social · 11/04/2026

Who's this guy newcastlebrc.nihr.ac.uk/news-and-eve...

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Wezi Sendama @wezisendama.bsky.social · 16/03/2026

Very proud to have been a tiny, tiny part of this.

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Wezi Sendama @wezisendama.bsky.social · 10/03/2026

Have completely neglected social media, but returning to announce that for some reason the MRC awarded me a Clinician Scientist Fellowship to investigate disordered pulmonary inflammation in older survivors of pneumonia! Will hopefully get down to some good science if the imposter syndrome wears off

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Wezi Sendama @wezisendama.bsky.social · 04/02/2025

Incredibly pleased to have been awarded a BIOREME Starter Grant! I'll be visiting the Statistical Biophysics lab at École Normale Supérieure in Paris to learn about probabilistic modelling of T cell receptor generation. I'll also be visiting as many local patisseries as possible.

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Wezi Sendama @wezisendama.bsky.social · 03/12/2024

Skimmed this and looks an incredible piece of work. Looking forward to digging into it a little more. Nicely done!

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Wezi Sendama @wezisendama.bsky.social · 30/11/2024

Even if the trial is negative, the real primary outcome was the friends you made along the way

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Wezi Sendama @wezisendama.bsky.social · 27/11/2024

Hopping into a canoe and paddling up the train tracks to Westminster for the BTS Winter Meeting

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Wezi Sendama @wezisendama.bsky.social · 16/11/2024

New preprint! We think it's possible to use TCR repertoire profiling to identify antigens in hypersensitivity pneumonitis. If two individuals with HP share disease-related TCRs, knowing one patient's HP antigen means you also know the other's. www.biorxiv.org/content/10.1...

biorxiv.org

T cell receptor sharing in hypersensitivity pneumonitis

Hypersensitivity pneumonitis (HP) is characterised by an excessive pulmonary T cell response in susceptible individuals after exposure to inhaled antigens. The most effective treatment for the conditi...

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Wezi Sendama @wezisendama.bsky.social · 08/11/2024

Back on here, I think. As good a time as any to mention that I'm giving a talk on ageing and pulmonary inflammation at the BTS Winter Conference in a couple of weeks... Maybe need to make the slides at some point

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Wezi Sendama @wezisendama.bsky.social · 20/12/2023

Editor-in-Training at the Blue Journal? Don't mind if I do

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Wezi Sendama @wezisendama.bsky.social · 19/11/2023

I don't think it's right to have a grant application window that opens in late November and closes at the end of January

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Wezi Sendama @wezisendama.bsky.social · 16/10/2023

Fewer than 24 hours until I have a chance to walk into a big building and make a fool of myself in front of some very important people

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Wezi Sendama @wezisendama.bsky.social · 03/10/2023

I have only ever met one person who has been able to convince me that they understand the kidney

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Wezi Sendama @wezisendama.bsky.social · 28/09/2023

Editor-in-chief sending me more manuscripts to send out for review when I'm already fighting for my life trying to find reviewers for the ones I had before

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Wezi Sendama @wezisendama.bsky.social · 22/09/2023

I would struggle to do this now with ggplot2

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Wezi Sendama @wezisendama.bsky.social · 18/09/2023

Only just skimmed this today but looks a phenomenal paper: gain-of-function mutation identified in a muscle hypertrophy syndrome, reproduced in a mouse model, treated in mice with inhibitor, then treated in patients successfully. Looking forward to reading properly. rupress.org/jem/article-...

rupress.org

Hemifacial myohyperplasia is due to somatic muscular PIK3CA gain-of-function mutations and responds ...

In this study, we have discovered that hemifacial myohyperplasia results from a somatic gain-of-function mutation in PI3KCA. Using a new mouse model, we investi

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Wezi Sendama @wezisendama.bsky.social · 18/09/2023

I'm Wezi, a doctor specialising in respiratory medicine in Newcastle with a clinical interest in interstitial lung diseases. I'm also a postdoc at Newcastle University, and I have research interests in the innate and adaptive immune responses of the lung to antigen inhalation. #HiSciSky

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Wezi Sendama @wezisendama.bsky.social · 14/09/2023

Great #PCCM MDT today. Haematologists and clinical immunologists brought along some cases of theirs to discuss: patients developing interstitial lung abnormalities secondary to CVID or after bone marrow transplant. Challenging cases, huge opportunity to learn how to do the best for these patients.

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Wezi Sendama @wezisendama.bsky.social · 13/09/2023

Late to the party, but the Jupyter extension for VS Code is a sanity-saver

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Wezi Sendama @wezisendama.bsky.social · 13/09/2023

Getting a feel for how Bluesky works while I hamfistedly work through some data processing, extracting T cell receptor sequences from publicly available scRNAseq datasets. Sounds boring but potentially very interesting if I can prove a hypothesis I have...

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