Neutralizing autoantibodies against interleukin-10 can result in a phenocopy of monogenic defects of interleukin-10 signaling in children and may be associated with inflammatory bowel disease (IBD)...

Chronic immune diseases are shaped by multiple inflammatory processes happening at the same time, each in different parts of the tissue. This is shown in a mouse study from Karolinska Institutet, publ...

Immunosuppressive drugs are currently the main therapeutic option for treating inflammatory bowel disease (IBD). However, fewer than half of patients achieve sustained benefit, and these treatments ca...

Liu et al. review how spatial omics technologies reveal the organization, interaction, and evolution of tumor cells and their microenvironment within tissues. They highlight analytical advances that t...

In Denmark, this Ph.D. student fell in love with an egalitarian society that values work-life balance

Julio Saez-Rodriguez discusses how MCP servers are helping AI connect to life science databases, making AI a more reproducible tool for research.

Microbiota-dependent tryptophan-derived indole deficiency is linked to mouse fetal resorption and human recurrent miscarriage. Tryptophan-derived indoles prime MDSCs and RORγt+ Tregs to suppress IFN-γ...

Chen et al. identify two distinct antigen-presenting cancer-associated fibroblast (apCAF) populations across multiple cancer types. Mesothelial-related apCAFs locate near cancer cells while fibrocyte-...

An intestinal organoid model recapitulates human microfold (M) cell function and transcriptomic profiling and biochemical assays demonstrate that M cells uptake and present antigens to the immune syst...

In 2025, a new wave of ‘off-the-shelf’ B cell-depleting modalities for the treatment of autoimmune diseases emerged, encompassing allogeneic cellular therapies, in vivo chimeric antigen receptor engin...

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Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Cytokines optimize and fine-tune effector T cell responses. Here, Jiang et al. utilize IL-9, with scarce receptor expression in normal tissues, to boost IL-9R engineered T cells for cancer therapy. IL...

Open position not only to work in my lab but also the Engblom lab!!👇🏼👇🏾👇👇🏿 “Lab manager in immunology and spatial biology” Come join the Engblom and Villablanca labs! A lab manager position is avail...

Oral microbiome shows rising importance in human health. Cha et al. present the human reference oral microbiome (HROM), comprising 72,641 high-quality genomes from 3,426 species, including 2,019 previ...

Colorectal cancer diagnoses have become increasingly common in adults 50 or younger in recent years, particularly in high-income countries like the U.S. A new study led by Harvard and Mass General Bri...

Karolinska Institutet is recruiting three Assistant Professors in two programs tied to SciLifeLab. SciLifeLab and DDLS Fellows (Assistant Professors) are six-year positions with generous recruitment p...

CD8+ T cells preferentially engage tumor cells in pockets termed CRATERs, which are rich with antigen presentation molecules and breach into the tumor mass from the stromal compartment. CRATERs expand...

Cancer cells exploit distant tissues and organs to escape immune surveillance by activating nociceptive neurons, which remodel tumor-draining lymph nodes into an immune-suppressed state. Blocking this...

Galeano Niño et al. show that extracellular bacteria dominate colorectal and oral tumor microniches, remodeling the microenvironment with reduced cell density, scattered epithelium, and low proliferat...

Inflammatory bowel diseases (IBD) have traditionally been considered T cell-driven disorders; however, accumulating evidence challenges this view and …

In a patient with treatment-resistant ulcerative colitis, CD19 CAR T-cell therapy led to drug-free remission and mucosal healing, suggesting that B-cell targeting may offer a novel therapeutic ...

Inflammatory bowel disease affects millions of people worldwide and currently lacks a cure. Eduardo Villablanca studies how inflammation starts and heals in the intestines, with the aim to find new tr...

A significant complication of Crohn’s disease (CD) is intestinal fibrosis, which narrows the bowel lumen to form a stricture. Creeping fat (CF) is the…

Are you an established expert within Data Driven Cell and Molecular biology, Epidemiology and biology of infection or Evolution and Biodiversity research, three of the four strategic areas for data-dr...

IL-25 treatment induces persistent adaptation of the small intestine, which is maintained by ILC2s with functional and epigenetic qualities of immune memory. Effector-memory ILC2s arise in multiple ti...

SPPL3 deletion modifies glycosylation on primary T cells, reducing allogeneic immune responses without impairing tumor control by anti-CD19 allogeneic CAR-T cells. SPPL3-null, TCR-sufficient anti-CD19...

Maternal antibodies fundamentally regulate gut immunity in the developing infant, yet the mechanisms underlying this process remain elusive. We found that maternal immunoglobulin G (IgG), ingested in ...

Sitio web oficial de Canal 13, primer canal de transmisión chileno en transformarse en una casa editorial que traspasa sus contenidos a todas sus plataformas como Internet, radio, cable y eventos mult...