TRAM is a regulator of myddosome assembly through dissociating MyD88 from the TLR–TIRAP complex to enable myddosome maturation and durable downstream signal transduction.

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The Inflammasome Lab, led by Prof Kate Schroder at IMB, University of Queensland — uncovering the molecular machines that drive inflammation, and turning that knowledge into new medicines.

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The 2026 Gordon Research Conference on Cell Death will be held in Les Diablerets, Vaud (fr) Switzerland. Apply today to reserve your spot.

The non-canonical inflammasome, comprising caspase-4 in humans, initiates pyroptosis upon sensing cytosolic lipopolysaccharide (LPS) from Gram-negativ…

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Join us at the Keystone Symposia on Innate Immunity: Diversity in Host Defense and Disease, March 2026, in Banff, with field leaders!

Institute for Molecular Bioscience Full-time (100%), permanent position Base salary will be in the range $117,958.12 - $132,247.57+ 17% Superannuation (HEW Level 8) Based at our St Lucia Campus About ...

Transcription factor osr2 is identified as a specific marker and regulator of mural lymphatic endothelial cell (muLEC) differentiation and maintenance, and muLECs and border-associated macrophages sha...

Caspase-2 inactivation promotes pathogenic hepatocyte polyploidy and age-related liver cancer.

Join us at the Keystone Symposia on Innate Immunity: Diversity in Host Defense and Disease, March 2026, in Banff, with field leaders!

Nature Structural & Molecular Biology - Cell death contributes to tissue homeostasis and plays critical roles in inflammation and host defense. Our increasing understanding of the physiological...

Join us at the Keystone Symposia on Innate Immunity: Diversity in Host Defense and Disease, March 2026, in Banff, with field leaders!

The coordination of efficient immune responses to infections is essential to enable pathogen clearance and host survival. Cell death modalities are a crucial component of the innate immune system and ...

Myeloperoxidase, a highly expressed neutrophil protein, disassembles nucleosomes, facilitating neutrophil extracellular trap (NET) formation, and binds stably to NETs extracellularly.

The ten eukaryotic COMMD proteins are core components of the Commander complex, with central roles in endosomal membrane trafficking and signalling. Each protein has an α-helical N-terminal (HN) domai...

imageimageAvailable caspase-4/11 (CASP4/11) inhibitors also block the activity of caspase-1 (CASP1), which complicates interpretation of results in functional studies and limits their clinical potenti...

imageimageAvailable caspase-4/11 (CASP4/11) inhibitors also block the activity of caspase-1 (CASP1), which complicates interpretation of results in functional studies and limits their clinical potenti...

With all the advances in both the science of aging and artificial intelligence (AI), we are in a propitious position to accurately and precisely determine who is at high risk of developing Alzheimer’s...