Targeted ablation of prostaglandin E2 (PGE2) signalling in CAR T cells enhances their activity in PGE2-rich solid tumours, with demonstrations of efficacy in vitro, in mouse xenografts and in patient-...

The cyclooxygenase (COX) signaling pathway is frequently dysregulated in cancer, resulting in aberrant production of prostaglandins - a distinct class of b

Nature Immunology - Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells....

Immune responses lie at the heart of almost every aspect of human health, including host responses to infection, autoimmunity, cancer, metabolism and aging. While adaptive immune responses by B and T…

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Ob Projekte gegen HIV, Malaria oder vernachlässigte Tropenkrankheiten: Die USA streichen ihre medizinische Entwicklungshilfe. Die Folgen sind schon jetzt dramatisch.

Societies should learn from this and speak up to support inclusion

The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.

In the midst of pandemic upheaval, researchers have gained fundamental insights about how the body fends off infections.

Rapid integration of glioblastoma into neuronal circuits promotes glioblastoma invasion and growth, as shown by rabies-based retrograde tracing. Targeting of neuron-tumor networks with pharmacological or rabies-mediated disconnection offers therapeutic potential.

As the nation’s top health official, he could discourage vaccine research and production, and dissuade Americans from getting shots.

Whether cytotoxic T lymphocytes (CTLs) exert protumorigenic effects remains elusive. Huang et al. reveal that macrophages cross-present to clonally expanded CD103+ CTLs in the pericancerous area in he...

Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...

Virtual immunology seminar series 2024 Organizers: Miriam Merad, Kazuyo Moro, Bali Pulendran, Gabriel Rabinovich, Caetano Reis e Sousa, Asya Rolls and Dietmar Zehn Q&A via X (former Twitter) @glob...

Poorly performing antibodies have plagued biomedical sciences for decades. Several fresh initiatives hope to change this.