Harsharan Bhatia @harsharanbhatia.bsky.social · 29/05/2026Thanks @daniellebeckman.bsky.social for sharing our recent work of DISCO-seq 🤗 030
Reposted by Harsharan BhatiaAli Maximilian Erturk @erturklab.bsky.social · 15/05/2026🧠 Does brain aging always mean vessel loss? We found the opposite in some aged brains: maladaptive hypervascularization, linked to cognitive decline and blood-brain barrier damage. Check it out below! www.biorxiv.org/content/10.6... 0188
Reposted by Harsharan BhatiaNicolas Denans @nicolasdenans.bsky.social · 18/12/2025Wow, @erturklab.bsky.social team did it again! Bringing science fiction to the real world 👋👋 021
Reposted by Harsharan BhatiaDoris Kaltenecker @dorie00.bsky.social · 19/12/2025Such a great study, combining tissue clearing, imaging and scRNA-Seq 👏🏼 021
Reposted by Harsharan BhatiaAlejandro Montenegro @aemonten.bsky.social · 18/12/2025"Conventional techniques restrict molecular profiling to pre-selected 2D sections, losing systemic context and introducing anatomical bias by sampling less than 0.001% of a whole organism. To overcome these challenges, we developed DISCO-seq" www.biorxiv.org/content/10.6...biorxiv.orgDISCO-seq: 3D single-cell transcriptomics of intact biological systemsSingle-cell transcriptomics has transformed tissue analysis, yet current methods struggle to integrate whole-tissue 3D architecture. Conventional techniques restrict molecular profiling to pre-selecte... 011
Harsharan Bhatia @harsharanbhatia.bsky.social · 18/12/2025Thrilled to share our work on DISCO-seq, which combines RNA-preserving tissue clearing with whole-organ 3D imaging to enable anatomically unbiased single-cell transcriptomics, with applications in cancer and infection biology. #SpatialBiology #DISCOseq Preprint link www.biorxiv.org/content/10.6...biorxiv.org 041
Reposted by Harsharan BhatiaPhilip Ruthig @philipruthig.bsky.social · 20/01/2025As of today, the main finding of my PhD is published in the European Journal for Neuroscience! 🥳🥳 Together with Gesine Müller, we looked at hemispheric asymmetries in the mouse auditory cortex. We find layer, sex, and hemispheric differences: doi.org/10.1111/ejn.... 🧵doi.orgHemispheric Asymmetry of Intracortical Myelin Orientation in the Mouse Auditory CortexWe find that the right and left auditory cortex in mice are both organised in cortical columns, with asymmetric myelination in the different layers and differences between the sexes. In addition, the... 3199
Reposted by Harsharan BhatiaNature Biotechnology @natbiotech.nature.com · 14/01/2025Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning - @erturklab.bsky.social @hendrikdietz.bsky.social go.nature.com/4gNLjeCgo.nature.comNanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning - Nature BiotechnologyAn integrated experimental and deep learning pipeline reveals cell-level targeting of nanocarriers in whole bodies. 13717
Reposted by Harsharan BhatiaSam Connell @samuelconnell.3i.social · 14/01/2025Congrats to the whole community in the @erturklab.bsky.social including first author @jie-luo-lab.bsky.social starting his new Lab at Purdue just last week! Nice work y'all! Amazing contribution to this growing body of work using LightSheet microscopy for whole mouse imaging. 🧪🧵🔬 092
Harsharan Bhatia @harsharanbhatia.bsky.social · 14/01/2025Our SCP-Nano paper is online now in Nature Biotechnology 🎉👏 Kudos to all the authors, collaborators and reviewers for bringing this important piece of work! #LNP #mRNA #nanotechnology #AAV #AI #imaging #nanocarrier 132
Harsharan Bhatia @harsharanbhatia.bsky.social · 14/12/2024Amazing experience to share the stage with spatial biology experts @European Society of Spatial Biology (ESSB) and present our work of 3D spatial-Omics to an audience of 550 plus from 26 countries 🤩 Kudos to the founding members of @SpatialBio for putting together such a fantastic event 🎉👏 #3D #Omic 061
Harsharan Bhatia @harsharanbhatia.bsky.social · 10/12/2024Let’s celebrate together the dawn of spatial proteomics- not just in 2D but in a groundbreaking 3D fashion, thanks to our pioneering work of DISCO-MS 🎉 010
Harsharan Bhatia @harsharanbhatia.bsky.social · 05/12/2024Check out our latest preprint-MouseMapper- charting the intact organism at cellular resolution #obesity #AI #inflammation #neurodegeneration #proteomics 040
Reposted by Harsharan BhatiaAli Maximilian Erturk @erturklab.bsky.social · 29/11/2024Our new study shows that SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it🔬🧠🦠🧵Your weekend read👇 @cellpress.bsky.social cell.com/cell-host-mi... 56736375
