Methodological advances in mapping transcriptome-wide RNA-protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA...

An estimated two million Australians live with a rare disease. Approximately 80% of rare diseases are genetic disorders.

Here the authors study how interactions with nuclear speckles help localize mRNA in cells. They find that modifications of the proteins in these structures affects their cohesion and can modulate mRNA...

Sasaki et al. demonstrate that chromosome missegregation induced by SAC inhibition results in cytoplasmic dsRNA accumulation, primarily generated from non-exonic regions in the MNs. Activation of MAVS-mediated dsRNA sensing cooperates with dsDNA sensing to promote anti-tumor immunity.

Trans-splicing-based methods that are independent of bacterial sequences and that allow the incorporation of RNA modifications enable the reliable synthesis of circular RNAs and enhance the efficiency...

AbstractSummary. APAtizer is a tool designed to analyze alternative polyadenylation events on RNA-sequencing data. The tool handles different file formats,

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Kamel et al. apply complementary approaches to elucidate the composition of Sindbis virus ribonucleoproteins. They identified a subset of nuclear proteins that selectively translocate to the cytoplasm, interact with viral RNA, and suppress virus infection. Among them, U2 snRNP emerges as a ribonucleoprotein complex with moonlighting antiviral activity.

Chan et al. and Ru et al., identify defective RNA processing as the root cause of impaired antiviral immunity against SARS-CoV2 in the human brainstem and

GGNBP2, CNOT10, and CNOT11 are required for innate immune response after the loss of ADAR1-mediated editing of self dsRNA.

Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate dendritic cells.

In humans, misprocessed mRNAs containing intact 5′ Splice Site (5′SS) motifs are nuclear retained and targeted for decay by ZFC3H1, a component of the Poly(A) Exosome Targeting complex, and U1-70K, a ...

An mRNA-encoded, dominant-negative inhibitor of RUNX1 exhibits preclinical efficacy in models of ocular diseases.

Studying RNA dynamics in vivo often relies on fluorogenic approaches, but these can be hampered by factors such as limited sensitivity and sample autofluorescence. Here, the authors describe an ultras...

Analysis of the genomes of 159 individuals from four Indigenous communities in Australia shows a high level of genetic variation and demonstrates the need for greater representation of Indigenous Aust...