Per moltiplicarsi, l’HIV deve trasportare il proprio materiale genetico nel nucleo della cellula e integrarlo nel DNA cellulare. Il genoma virale viaggia protetto all’interno del capside, un involucro proteico che svolge un ruolo essenziale durante le prime fasi dell’infezione.

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Ultrastructural analysis reveals that LEN stabilizes capsids in nuclei, reprogramming HIV-1 trafficking to PML-NBs.

Cell-to-cell spread reprograms resting CD4⁺ T cells to permit infection. Mesner et al. show that contact between infected and uninfected T cells triggers CD4–LCK signaling, activating CDK1 independent...

𝐌𝐚𝐫𝐢𝐧𝐚 𝐂𝐚𝐯𝐚𝐳𝐳𝐚𝐧𝐚, 𝐥𝐚 𝐩𝐢𝐨𝐧𝐢𝐞𝐫𝐚 𝐝𝐞𝐥𝐥𝐚 𝐭𝐞𝐫𝐚𝐩𝐢𝐚 𝐠𝐞𝐧𝐢𝐜𝐚.    🧬Dirigente di Bioterapia all’Ospedale INEM - Institut Necker Enfants Malades di Parigi e Direttore del Centro di Investigazione Clinica per la Bi...

Viruses that access the nucleus must navigate the highly regulated barrier of the nuclear envelope via the nuclear pore complex (NPC), a dynamic structure whose size and properties have been recently ...

HIV hijacks SRRM2 to enlarge nuclear speckles, stabilizing CPSF6 puncta and promoting efficient viral replication.

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Le Work in progress de l'action coordonnée 41 « Interactions Hôte-VIH, recherche fondamentale et translationnelle » se tiendra en présentiel le 25 mars 2025 à l'Institut Pasteur à Paris.

imageimageIn vitro infection studies have shown that HIV-1 entry into the nucleus triggers the formation of dynamic structures called HIV-1 membraneless organelles (HIV-1-MLOs). This study reveals the...