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Pieter Meysman

@pmeysman.bsky.social
306 followers 128 following 67 posts

Professor in biomedical data science at the University of Antwerp. Part-time CTO of ImmuneWatch. Immunoinformatics with a focus on T-cell receptors.

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Pieter Meysman @pmeysman.bsky.social · 01/06/2026
New paper in @cp-cellreports.bsky.social where we mapped out the interactions between the microbes that live in the human gut and your repertoire of T-cells, which defend against cancer and infection! doi.org/10.1016/j.ce...
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Pieter Meysman @pmeysman.bsky.social · 20/05/2026
Modern cancer immunotherapies are highly personal, tuned to a specific individual. Highly effective and extremely cool, but how do we do quality control on something that is unique? What if we combined ever cheaper NGS with state-of-the art annotation tools? www.sciencedirect.com/science/arti...
sciencedirect.com
Applications of T-cell receptor specificity annotation models for quality control and immunomonitoring in adoptive T-cell therapies
Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TIL) is a powerful candidate immunotherapy. However, the personalized production proc…
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Pieter Meysman @pmeysman.bsky.social · 20/05/2026
How effective were SARS-CoV-2 vaccines in inducing an immune response in blood cancer patients? And what lessons can we learn for future vaccination programs? (Hint: Antibodies aren't the full story) www.frontiersin.org/journals/imm...
frontiersin.org
Frontiers | CORSA study finds spike-specific blunted immune responses in lymphoma patients after SARS-CoV-2 vaccine
IntroductionHematological patients are at higher risk of severe SARS-CoV-2 infection and exhibit impaired vaccine responses due to disease and therapy. Treat...
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Pieter Meysman @pmeysman.bsky.social · 11/05/2026
From an interesting workshop to an exciting review: What are the best practices to assess the immunogenicity of a novel therapy in silico? www.frontiersin.org/journals/imm...
frontiersin.org
Frontiers | Review: Application and opportunities for machine learning and artificial intelligence in preclinical immunogenicity risk assessment
The unwanted immune response to Biologic Therapies can result in anti-drug antibodies that complicate clinical development and may adversely affect patient o...
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Pieter Meysman @pmeysman.bsky.social · 17/04/2026
Excited to be at the ISLH conference today to talk about where we are with using TCR-epitope AI tools for hematology.
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Pieter Meysman @pmeysman.bsky.social · 07/04/2026
The preprint on IMMREP25 TCR-epitope prediction challenge is now out on preprint, which reveals that unseen epitopes remains an unsolved problem in the field! doi.org/10.64898/202...
doi.org
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Pieter Meysman @pmeysman.bsky.social · 18/03/2026
Annotating novel T-cell receptors with their epitopes is something that I have put a lot of thought into the past decade. So I was excited to help actually frame an opinion on the topic in a white paper with ImmuneWatch: www.immunewatch.com/news/white-p...
immunewatch.com
New White Paper: How Reliable Are Antigen-Specificity Annotations for T-Cell Receptors?
ImmuneWatch white paper examining the reliability of computational TCR-antigen specificity annotations, covering database matching, seen epitope algorithms, and the validation behind DETECT.
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AIRR-Community @airr-community.bsky.social · 27/02/2026
🚀 Registration is now OPEN for AIRR Community Meeting VIII: Decoding and Recoding Immunity! Join us June 8–11, 2026 at Yale University (USA) or attend virtually. 💸 Early-bird rates available until April 15! 🔗 Register: tinyurl.com/airrcmeeting8 #AIRRC8 #immunosky
tinyurl.com
AIRR Community Meeting VIII.
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Pieter Meysman @pmeysman.bsky.social · 02/03/2026
Excited to have contributed to this review on how new technologies - including immunopeptidomics and TCR sequencing - might finally break the deadlock on a #Leishmania vaccine with Paul Kaye and Wim Adriaensen: doi.org/10.1016/j.pt...
doi.org
Redirecting
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Sander Wuyts, PhD 🧬 @swuyts.bsky.social · 25/02/2026
For the latest episode of The Repertoire Room Podcast, I sat down with Samra Turajlic after her talk at The Festival of Genomics and Biodata. "We could only understand this because we were able to track the clones through TCR sequencing." Check it out on YouTube: www.youtube.com/watch?v=QnRd...
youtube.com
Multiomics and TCR Sequencing in Immunotherapy | Repertoire Room Ep. 5
YouTube video by ImmuneWatch
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Pieter Meysman @pmeysman.bsky.social · 29/10/2025
How can #AI help decode our #immune systems and help for next generation #diagnostics? Here is a technical overview from the @airr-community.bsky.social diagnostics working group on where we currently are on this problem: doi.org/10.1016/j.im...
doi.org
Redirecting
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Pieter Meysman @pmeysman.bsky.social · 26/09/2025
Very proud to have been a jury member at the newly revived @iscb.bsky.social RSG Belgium hackathon! Exciting to see so many people giving their best efforts tackling challenging #bioinformatics problems!
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Pieter Meysman @pmeysman.bsky.social · 21/07/2025
The AIRR Diagnostics WG commentary is now available, wherein our members discuss both the challenges of current #AIRR-based #diagnostics, as well as the future directions that we see the field going into! www.sciencedirect.com/science/arti...
sciencedirect.com
Challenges and Future Directions of AIRR-seq-Based Diagnostics
Adaptive Immune Receptor Repertoire sequencing (AIRR-seq) is a promising diagnostic method across various clinical conditions, yet its widespread impl…
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Pieter Meysman @pmeysman.bsky.social · 29/05/2025
That's it. #ATCR25 is over! Thanks again to all attendees, speakers and support staff for making this an amazing meeting!
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Pieter Meysman @pmeysman.bsky.social · 28/05/2025
Last #ATCR25 speaker: Paul Thomas on deciphering the T cell receptor recognition code.
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Pieter Meysman @pmeysman.bsky.social · 28/05/2025
Fifth speaker on #ATCR25 day 2: Michael Birnbaum on high throughput TCR analysis and generation.
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Pieter Meysman @pmeysman.bsky.social · 28/05/2025
Fifth speaker, #ATCR25 day 2: Encarnita Mariotti-Ferrandiz on TCR repertoire signatures in auto immune and infectious disease.
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Pieter Meysman @pmeysman.bsky.social · 28/05/2025
Fourth speaker, #ATCR25 day 2: Hashem Koohy on decoding antigen-specific T cell recognition.
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Pieter Meysman @pmeysman.bsky.social · 28/05/2025
Third speaker, #ATCR25 day 2, Soumya Raychaudhuri on how the HLA affects the TCR repertoire, and how the TCR affects cell fate.
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Pieter Meysman @pmeysman.bsky.social · 28/05/2025
Second speaker, #ATCR25 day 2: Antonio Lanzavecchia on CD8 T cell immunodominance
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Pieter Meysman @pmeysman.bsky.social · 28/05/2025
First speaker, second #ATCR25 day: Mark Davis on analyzing the T cell response.
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Pieter Meysman @pmeysman.bsky.social · 27/05/2025
#ATCR25 short talk 8: Nicole Mifsud on the immune signatures of alloreactive T cells during transplantation rejection.
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Pieter Meysman @pmeysman.bsky.social · 27/05/2025
#ATCR25 short talk 7: Vincent Van Deuren on using TRIASSIC to identify convergent TCR clusters in the synovial fluid of rheumatoid arthritis patients.
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Pieter Meysman @pmeysman.bsky.social · 27/05/2025
#ATCR25 short talk 6: Orian Bricard on using TWISTAR to identify cognate cancer epitopes of a TCR of interest.
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Pieter Meysman @pmeysman.bsky.social · 27/05/2025
#ATCR25 short talk 5: Giancarlo Croce on using phage display screening to identify cancer-specific TCRs at the epitope level.
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Pieter Meysman @pmeysman.bsky.social · 27/05/2025
#ATCR25 short talk 4: Mikhail Pogorelyy on TIRTLseq for a cheaper paired TCR sequencing.
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Pieter Meysman @pmeysman.bsky.social · 27/05/2025
#ATCR25 short talk 3: Bjorn Kwee on the possibility that TCR-epitope prediction is poor because the underlying data has more false positives than commonly believed.
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Pieter Meysman @pmeysman.bsky.social · 27/05/2025
#ATCR25 short talk 2: Abi Colley on building a TCR-epitope data set capturing variability on both the TCR and epitope side to build an annotation model.
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Pieter Meysman @pmeysman.bsky.social · 27/05/2025
#ATCR short talk 1: Sofie Gielis on the influence of data on TCR-epitope predictions.
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Pieter Meysman @pmeysman.bsky.social · 27/05/2025
Fifth #ATCR25 speaker: @kischober.bsky.social on how T cell receptor avidity influences clonal expansion following antigen exposure in a "natural experiment" (vaccination)
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Pieter Meysman @pmeysman.bsky.social · 27/05/2025
Fourth #ATCR25 speaker: Dietmar Zehn on the formation of seemingly exhausted T cells during acute infections, with the theory that this is tied to the affinity of the TCR-pMHC interaction.
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Pieter Meysman @pmeysman.bsky.social · 27/05/2025
Third #ATCR25 talk by Hannah Meyer on using BATMAN to model the TCR cross reactivity space.
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Pieter Meysman @pmeysman.bsky.social · 27/05/2025
Second #ATCR25 talk by Johanna Olweus on using therapeutic TCR T cells to target cancer antigens
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Pieter Meysman @pmeysman.bsky.social · 27/05/2025
First #ATCR25 talk by Dirk Busch on the diversity and cross-reactivity of epitope-specific TCRs, which might be a redundancy of our immune system to anticipate escape mutations.
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Pieter Meysman @pmeysman.bsky.social · 27/05/2025
Ready to start the #ATCR25 meeting celebrating 10 years of the AUDACIS consortium with this amazing line-up of speakers!
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Pieter Meysman @pmeysman.bsky.social · 06/05/2025
#ATCR25 acceptance notifications just went out! We had 76 abstracts of very high quality, but could only accept 8 for short talks (so 10%). Huge thanks to our review committee for making though decisions. Really excited where the #TCR field is going based on the abstracts I saw!
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Pieter Meysman @pmeysman.bsky.social · 14/04/2025
#Abstract submission deadline for #ATCR2025 is this Friday! We are again very grateful to have such a strong lineup of #Tcell-receptor experts joining us in Antwerp. Currently at 80% capacity so do not wait to register. www.uantwerpen.be/atcr2025
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Sander Wuyts, PhD 🧬 @swuyts.bsky.social · 06/02/2025
Attending the public PhD defence of Sebastiaan Valkiers on the topic of: "Decoding the TCR landscape in MS" Jury members: @enkrnita.bsky.social @yvansaeys.bsky.social Bart Goethals Promoters: @krislaukens.bsky.social @pmeysman.bsky.social
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Pieter Meysman @pmeysman.bsky.social · 20/01/2025
Registration and abstract submission to ATCR2025 in May are now open! We have assembled a truly inspiring keynote lineup to discuss everything #T-cell-receptor! www.uantwerpen.be/atcr2025
uantwerpen.be
Antwerp TCR conference 2025 | Antwerp TCR conference 2025 | University of Antwerp
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Yellow4FLAVI @yellow4flavi.bsky.social · 27/12/2024
Yellow4FLAVI's Bluesky account is now live!! #EUproject funded by @EU_HaDEA #HorizonEurope #Health Visit our website yellow4flavi.eu #flavivirus #yellowfever #vaccine #pandemic #zika #dengue #lifesciences #EUcooperation
yellow4flavi.eu
Yellow4FLAVI | Inform flavivirus vaccine design
Yellow4FLAVI Project. Deconstructing the protective immunity of yellow fever virus 17D to inform flavivirus vaccine design.
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Pieter Meysman @pmeysman.bsky.social · 13/12/2024
Very excited that today the FWO granted my two #immunology #AI research projects! * One on modelling #Tcells after #vaccination with my good friend Benson Ogunjimi * One on mapping the human #MHC presentation space with the ever talented Wout Bittremieux
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Pieter Meysman @pmeysman.bsky.social · 12/12/2024
The annual gathering of #Antwerp bioinformatics at the @biomina.bsky.social Research Day kicked off by @krislaukens.bsky.social ! Always amazing to see how varied #bioinformatics applications are!
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ImmunoSketch @actuallypublished.bsky.social · 07/12/2024
Unlocking the secrets of our immune system is like discovering hidden treasures in a library, where each book holds the key to better health. @pmeysman.bsky.social @cziscience.bsky.social www.science.org/doi/10.1126/... #ImmunoSky 🧪
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ImmuneWatch @immunewatch.bsky.social · 06/12/2024
Happy with the first official citation of ImmuneWatch DETECT in a publication 👇 ImmuneWatch DETECT finds the specificity of T cell receptor clusters in a new Science Advances paper www.immunewatch.com/news/immunew...
immunewatch.com
ImmuneWatch DETECT finds the specificity of T cell receptor clusters in a new Science Advances paper
ImmuneWatch DETECT is featured in a new research paper: T cell receptor–centric perspective to multimodal single-cell data analysis published in Science Advances
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Pieter Meysman @pmeysman.bsky.social · 02/12/2024
Our massive effort to recontextualize #single #T-cell data is now out in Science Advances! We developed a new system, STEGO, to do a TCR-first analysis, and reanalyzed 12 studies and more than 500 000 individual T-cells. Supported by @cziscience.bsky.social ! doi.org/10.1126/scia...
doi.org
T cell receptor–centric perspective to multimodal single-cell data analysis
T cell receptor–centric perspective improves single-cell analysis.
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Pieter Meysman @pmeysman.bsky.social · 26/11/2024
Why do TCR analysis tools (tcrdist, nettcr, etc) rely on substitution matrices made for evolution, like blosum? And could we improve them with a dedicated substitution matrix? academic.oup.com/bib/article/...
academic.oup.com
tcrBLOSUM: an amino acid substitution matrix for sensitive alignment of distant epitope-specific TCRs
Abstract. Deciphering the specificity of T-cell receptor (TCR) repertoires is crucial for monitoring adaptive immune responses and developing targeted immu
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Sander Wuyts, PhD 🧬 @swuyts.bsky.social · 21/11/2024
Calling all T-cell aficionado's. Come and join us next year (27-28 May 2025) for the fourth Antwerp T-Cell Receptor conference organised by @pmeysman.bsky.social, @krislaukens.bsky.social and Benson Ogunjimi. I'll also be there! www.uantwerpen.be/en/conferenc... #ImmunoSky
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