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Nazgul Sakenova

@nazgulsakenova.bsky.social
278 followers 89 following 6 posts

HHMI-HHWF PostDoc in Bernhardt lab at Harvard | bacterial cell biology PhD @typaslab.bsky.social at EMBL | systems microbiology

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Reposted by Nazgul Sakenova
anna brogan @apbrogan.bsky.social · 23/06/2026
Another chapter of my thesis is out! We asked whether we could pair proteome-wide AlphaFold screening with Tn-seq to identify biologically relevant protein-protein interactions. We identify ClcR (formerly YerH) as a component of the Rod complex in Gram-positive bacteria. www.pnas.org/doi/10.1073/...
pnas.org
A broadly conserved gram-positive lipoprotein regulates cell elongation | PNAS
The cell wall peptidoglycan (PG) protects virtually all bacteria from osmotic lysis and specifies cell shape. Synthesis of this exoskeleton is carr...
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Reposted by Nazgul Sakenova
Typas Lab @typaslab.bsky.social · 20/08/2026
Excited to share our paper with @savitski-lab.bsky.social, led by @tarabartolec.bsky.social, Karin Mitosch & Clément Potel, out now in @nature.com. We show that T7 phage broadly disables bacterial defenses using a unique ‘loose cannon’ protein kinase. www.nature.com/articles/s41...
nature.com
Pervasive phosphorylation by phage T7 kinase disarms bacterial defences - Nature
The T7 bacteriophage deactivates bacterial defence systems through T7K phosphorylation of nearly all host and phage proteins during infection.
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Reposted by Nazgul Sakenova
Typas Lab @typaslab.bsky.social · 13/10/2025
Excited to share our preprint led by Carlos Voogdt et al We developed new genetic tools & genome-wide libraries for species of the Bacteroidales order; constructed saturated barcoded transposon libraries in key representatives of three genera. www.biorxiv.org/content/10.1...
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Reposted by Nazgul Sakenova
Goemans Lab @goemanslab.bsky.social · 07/05/2025
How the @embo.org postdoctoral fellowship helped me in developing my academic career... happy to see my profile featured on the EMBO website! www.embo.org/people/from-...
embo.org
From Fellowship to Frontline: Camille Goemans’ Mission to Tackle Antibiotic Resistance – People – EMBO
An interview with Camille Goemans, tenure-track assistant professor at the École Polytechnique Fédérale de Lausanne (EPFL) in Lausanne, Switzerland and former EMBO Postdoctoral Fellow
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Reposted by Nazgul Sakenova
Alf Soler-Bistué 🦠🔬🧫 @alfmicrobe.bsky.social · 10/04/2025
I was waiting two years to see this out!! The genomic location of bacterial genes is not random!!! Congratulation on the authors (Martin Lercher and Team!). www.science.org/doi/10.1126/...
science.org
Most bacterial gene families are biased toward specific chromosomal positions
The arrangement of genes along bacterial chromosomes influences their expression through growth rate–dependent gene copy number changes during DNA replication. Although translation- and transcription-...
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Nazgul Sakenova @nazgulsakenova.bsky.social · 16/12/2024
I attended the course in 2022, as it’s held every three years. It combines diverse, exciting science with close-knit socializing on a beautiful Greek island. Highly recommended for PhD students at any stage!
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Reposted by Nazgul Sakenova
Nature Portfolio @natureportfolio.nature.com · 07/12/2024
Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. A study in Nature Microbiology presents an approach to systematically discover and understand such antibiotic relationships. go.nature.com/49of3Mk 🧪
This is figure 4, which shows collateral sensitivity and cross-resistance interactions between and within antibiotic classes.
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Reposted by Nazgul Sakenova
EMBL @embl.org · 02/12/2024
(1/3) Antibiotic resistance is costing human lives. 🦠 A study from EMBL's Typas group proposed a framework to identify antibiotic pairs that make bacteria resistant to one antibiotic but sensitive to other – this can help design new treatments and delay resistance. 🧬🧪 www.nature.com/articles/s41...
Credit: Daniela Velasco Lozano/EMBL
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Nazgul Sakenova @nazgulsakenova.bsky.social · 02/12/2024
My PhD work is now published in Nature Microbiology! Please, have a look!
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Nazgul Sakenova @nazgulsakenova.bsky.social · 29/01/2024
Antibiotic (abx) resistance is outpacing new abx discovery. This is worsened by cross-resistance (XR) between abx. However, resistance can also lead to collateral sensitivity (CS) to other abx, providing new treatment opportunities. In our new preprint www.biorxiv.org/content/10.1...
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