iiinova — where your digital self keeps evolving

ImmunoSketch @actuallypublished.bsky.social · 31/12/2024

This concludes our 10-day journey and the ImmunoSketch adventure. Thank you for joining in. May your new year be as resilient and adaptive as the cells we study. Happy new year! 🎄

030

ImmunoSketch @actuallypublished.bsky.social · 31/12/2024

Hidden among our immune system's seeds, scientists found special ones that could revolutionize cancer treatments and vaccines. @deekshadeep @danapeer.bsky.social @jexpmed.bsky.social t.co/k5lwZHxzxi #ImmunoSky 🧪

032

ImmunoSketch @actuallypublished.bsky.social · 31/12/2024

And for the grand finale: Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity. A perfect reminder of immunology’s complexity—how one decision can shape an entire fate.

ImmunoSketch @actuallypublished.bsky.social · 30/12/2024

Imagine tiny engineers in your skin fine-tuning your nerves to detect allergens more easily. @theILCguy @sokol_mdphd @forum-gd.bsky.social @nature.com t.co/FjDjJ7U8Db #ImmunoSky 🧪

031

ImmunoSketch @actuallypublished.bsky.social · 30/12/2024

Day -2 highlights an immune-sensory dialogue: A γδ T cell–IL-3 axis controls allergic responses through sensory neurons. Immunology doesn’t just fight disease—it listens, connects, and responds. A beautiful symphony of cells to close out the year.

ImmunoSketch @actuallypublished.bsky.social · 29/12/2024

Imagine your immune system as a symphony, where testosterone conducts uniquely tuned performances. @petterbrodin.bsky.social @karolinskainst.bsky.social @nature.com t.co/PP6pbUIuph #ImmunoSky 🧪

043

ImmunoSketch @actuallypublished.bsky.social · 29/12/2024

On day -3, we spotlight adaptation: Immune system adaptation during gender-affirming testosterone treatment. A testament to the immune system’s flexibility and resilience—much like the spirit we carry into the new year.

ImmunoSketch @actuallypublished.bsky.social · 28/12/2024

Even at the very start, some cells in the embryo already have different jobs. @LIwamotoStohl @zernickagoetz.bsky.social @slavovlab.bsky.social t.co/BYpgqsn6G0 #ImmunoSky 🧪

ImmunoSketch @actuallypublished.bsky.social · 28/12/2024

Day -4 turns our focus to early development: Proteome asymmetry in mouse and human embryos before fate specification. A fascinating reminder that immune-related pathways often begin shaping outcomes before fate is even sealed.

ImmunoSketch @actuallypublished.bsky.social · 27/12/2024

Imagine the uterine lining as a garden, where special cells act as dedicated gardeners, keeping it healthy and vibrant. @vikilovesfacs.bsky.social t.co/CMnUKp26hw #ImmunoSky 🧪

021

ImmunoSketch @actuallypublished.bsky.social · 27/12/2024

On day -5, we celebrate immune cells in regeneration: Dynamic roles of ILC3 in endometrial repair and regeneration. Just like the new year brings fresh beginnings, ILC3s show us how the immune system fosters repair and renewal.

ImmunoSketch @actuallypublished.bsky.social · 26/12/2024

Septins act like tiny security guards in our cells, triggering a self-destruct mode to fight off harmful bacteria. @MostowyLab @DBrokatzky @lshtm.bsky.social @cp-cellchembiol.bsky.social t.co/0bmT2fA51l #ImmunoSky 🧪

ImmunoSketch @actuallypublished.bsky.social · 26/12/2024

Day -6 dives into the mechanics of cell death: Septins promote macrophage pyroptosis. Who knew cell death pathways could bring such dramatic energy to the immunology stage?

120

ImmunoSketch @actuallypublished.bsky.social · 25/12/2024

Breast cancer cells can be kept in check in the lungs by immune cell guardians that send a "sleep signal". @eriDalla @micpapanicolaou.bsky.social @JAguirreGhiso @casanova-acebes.bsky.social @miriammerad.bsky.social @dentenberg.bsky.social t.co/9GAh70ozST #ImmunoSky 🧪

040

ImmunoSketch @actuallypublished.bsky.social · 25/12/2024

Day -7 brings us a lesson in perfect timing: Lung-resident alveolar macrophages regulate the timing of breast cancer metastasis. A reminder that, like the holiday season, the immune system knows when to act—and when to wait.

ImmunoSketch @actuallypublished.bsky.social · 24/12/2024

Bacteria outsmart phages with a clever card trick, going dormant to dodge attacks. @drdorsalomon.bsky.social @naturemicrobiol.bsky.social t.co/S5qOcoCFOj #ImmunoSky 🧪

ImmunoSketch @actuallypublished.bsky.social · 24/12/2024

Day -8 shines a light on nature’s microscopic defense systems: Gamma-Mobile-Trio systems are mobile elements rich in bacterial defensive and offensive tools. Like an immune system stocking stuffer, these mobile elements carry all the surprises—tools for attack and defense.

ImmunoSketch @actuallypublished.bsky.social · 23/12/2024

On day -9 of our year-end countdown, we celebrate immune engineering at its finest: A tetraspecific engager armed with a non-alpha IL-2 variant harnesses NK cells against B cell NHL. Natural killer cells armed and ready—it’s immunology’s version of Santa’s sleigh delivering precision medicine.

140

ImmunoSketch @actuallypublished.bsky.social · 22/12/2024

In newborns, tiny traffic cops in the liver need a GPS to find their way to the bloodstream and protect against infections. @brunaraujodavid @Kubes_Lab @immunoeditor.bsky.social @sciimmunology.bsky.social t.co/YU2WdkN4HF #ImmunoSky 🧪

032

ImmunoSketch @actuallypublished.bsky.social · 22/12/2024

Day -10: Today’s highlight takes us to the liver: Kupffer cell reverse migration into liver sinusoids mitigates neonatal sepsis and meningitis. Proof that even immune cells can come home for the holidays—and do remarkable things when they get there.

ImmunoSketch @actuallypublished.bsky.social · 22/12/2024

Thank you for reading, sharing, and engaging. Immunology will march on, and so will we—toward more discoveries, more papers, and hopefully, more ways to make sense of it all. Happy holidays and here’s to a new year full of resilience, balance, and maybe a few less cytokines.

ImmunoSketch @actuallypublished.bsky.social · 22/12/2024

Maybe it clarified a concept, sparked curiosity, or at least made someone say, “Huh, that’s actually pretty cool.” Because it is. To wrap it all up with a proper farewell, I’ll revisit 10 of the best posts over the next 10 days—one each day as we count down to the year’s end.

100

ImmunoSketch @actuallypublished.bsky.social · 22/12/2024

it’s the pursuit of answers to systems more complex than any holiday dinner debate you’ll face this season. It’s bittersweet to close this chapter, but I’m proud to have put this work out into the world.

100

ImmunoSketch @actuallypublished.bsky.social · 22/12/2024

Immunology is hard to explain, and harder still to simplify without losing its elegance. But I hope these posts shed light on why we obsess over the beautiful chaos of immune regulation. Science isn’t just papers and data—

100

ImmunoSketch @actuallypublished.bsky.social · 22/12/2024

After six months, the ImmunoSketch project has officially reached its end. The goal? To take our intricate, jargon-heavy science and turn it into something your loved ones might finally understand—so they stop assuming you just “look at cells” all day.

240

ImmunoSketch @actuallypublished.bsky.social · 21/12/2024

CAR-T cells aim to hit cancer targets, but when the target’s unclear, treatment struggles to succeed. @freemanlciaraMD @DrFredLocke @bloodjournal.bsky.social t.co/bPTq2SJzx8 #ImmunoSky 🧪

030

ImmunoSketch @actuallypublished.bsky.social · 21/12/2024

Scientists turned a harmless skin bacterium into a powerful vaccine delivery tool, boosting immunity in the lungs and nose. @mfgrp.bsky.social @djenetbousbaine.bsky.social @nature.com t.co/xXXCJx5VYm #ImmunoSky 🧪

0134

ImmunoSketch @actuallypublished.bsky.social · 21/12/2024

Some immune cells fuel the fire of disease, while others help put it out—finding the balance could change treatments. @juliosds1.bsky.social t.co/8HpBNRQ9Wv #ImmunoSky 🧪

051

ImmunoSketch @actuallypublished.bsky.social · 19/12/2024

Tracking bacterial ‘seeds’ in new soil reveals how they grow, adapt, and pave the way for next-gen microbiome therapies. @gangfang.bsky.social @biorxivpreprint.bsky.social t.co/QisGjqmInv #ImmunoSky 🧪

032

ImmunoSketch @actuallypublished.bsky.social · 17/12/2024

Unlocking how bacteria form tiny clusters like marbles could lead to better cystic fibrosis treatments. @DarchLab @AlexaGannon @usouthflorida.bsky.social t.co/L3Af0Z7nQp #ImmunoSky 🧪

ImmunoSketch @actuallypublished.bsky.social · 17/12/2024

Think of a conductor guiding an orchestra—scientists discovered how T cells fine-tune their responses to keep the immune system in harmony. @MarsonLab @KroganLab @jkpritch.bsky.social @natureportfolio.bsky.social @gladstoneinst.bsky.social t.co/VeyYIs40LM #ImmunoSky 🧪

ImmunoSketch @actuallypublished.bsky.social · 17/12/2024

Neutrophils cast chromatin nets to trap tuberculosis, but these nets also feed the bacteria, fueling the disease. @stallingslab.bsky.social @cellpress.bsky.social t.co/RGDWLHnvJP #ImmunoSky 🧪

080

ImmunoSketch @actuallypublished.bsky.social · 17/12/2024

CCDC134 is the immune system's mailroom supervisor, sorting and delivering critical defense signals to keep us protected. @rebsamenlab.bsky.social @lbernaleau.bsky.social @jexpmed.bsky.social @unil.bsky.social t.co/CikWuMuPCx #ImmunoSky 🧪

000

ImmunoSketch @actuallypublished.bsky.social · 17/12/2024

Cancer treatments can jam immune signals, raising heart risks—scientists chart a path to smoother strategies. @ChiaraGiannare1 @kathrynmoorelab @natureportfolio.bsky.social t.co/lPkYiK4Kdw #ImmunoSky 🧪

000

ImmunoSketch @actuallypublished.bsky.social · 11/12/2024

Got an immuno paper in mind that deserves the pencil-sketch summary? Drop your picks below! #ImmunoSky 🧪 #Immunology #SciComm

ImmunoSketch @actuallypublished.bsky.social · 11/12/2024

Imagine cells bursting into tiny fireworks to alert the immune system and spark a powerful defense. @carolinelholley.bsky.social @inflammasomelab.bsky.social @jkagan.bsky.social @samstehbens.bsky.social @doktrnick.bsky.social t.co/dE9wPARavh #ImmunoSky 🧪

0125

ImmunoSketch @actuallypublished.bsky.social · 10/12/2024

Boosting your body's bees with D-mannose keeps them buzzing against cancer. @Guideng4 @SuYapeng @cellpress.bsky.social @fredhutch.bsky.social t.co/LIvPi24fjl #ImmunoSky 🧪

ImmunoSketch @actuallypublished.bsky.social · 10/12/2024

Scientists have unlocked a new way to tinker with our genes, like having a keyring that can open or close almost any lock in our bodies. @AdrianoAguzzi @lucaspelkmans.bsky.social @MartinUCSF @natureportfolio.bsky.social t.co/HXs7ocrpyV #ImmunoSky 🧪

ImmunoSketch @actuallypublished.bsky.social · 07/12/2024

Unlocking the secrets of our immune system is like discovering hidden treasures in a library, where each book holds the key to better health. @pmeysman.bsky.social @cziscience.bsky.social www.science.org/doi/10.1126/... #ImmunoSky 🧪

041

ImmunoSketch @actuallypublished.bsky.social · 06/12/2024

When bacteria learn to resist one antibiotic, it's like learning a language, making similar ones easier but others harder to master. @typaslab.bsky.social @nazgulsakenova.bsky.social @embl.org @naturemicrobiol.bsky.social t.co/y8Vc2LNHwY #ImmunoSky 🧪

030

ImmunoSketch @actuallypublished.bsky.social · 05/12/2024

HIV hides in protective "cocoons" within cells, staying infectious for weeks and evading drug treatments, but destroying these cocoons stops the virus. @di-nunzio-lab.bsky.social @pasteur.fr @embojournal.bsky.social @embopress.org www.embopress.org/doi/full/10.... #ImmunoSky 🧪

052

ImmunoSketch @actuallypublished.bsky.social · 04/12/2024

Like a photographer choosing between quick snapshots or careful portraits, our immune system balances fast action and precise antibody creation. @profshanecrotty @katyely.bsky.social @johnmlindner.bsky.social @cellpress.bsky.social @emoryuniversity.bsky.social t.co/E2WUBinqCd #ImmunoSky 🧪

172

ImmunoSketch @actuallypublished.bsky.social · 04/12/2024

A starter pack for PhD students and Postdocs in Immunology to connect 🔽 Drop a 🧬 and I'll add you to the list. Let's build the upcoming immuno community! #ImmunoSky 🧪 go.bsky.app/RABVXY4

799758

ImmunoSketch @actuallypublished.bsky.social · 03/12/2024

Even after COVID-19 clears, parts of the virus can linger in the brain like a song stuck on repeat, causing lasting symptoms. @erturklab.bsky.social @markuselsner.bsky.social @harsharanbhatia.bsky.social @faridahellal.bsky.social @tumuenchen.bsky.social t.co/ExdcGIhM3Q #ImmunoSky 🧪