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Gladstone Institutes

@gladstoneinst.bsky.social
701 followers 165 following 959 posts

To drive a new era of discovery in disease-oriented science and to mentor tomorrow’s leaders in an inspiring and diverse environment.

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Gladstone Institutes @gladstoneinst.bsky.social · 29/09/2026
It's World Heart Day. Heart failure affects approximately 64 million people worldwide. At Gladstone, Michael Alexanian is asking: what if we could just switch it off? He's found two genes, BRD4 & MEOX1, that may hold the answer.
gladstone.org
Ask a Scientist: Can We Turn Off the Molecular Switches That Cause Heart Failure?
Michael Alexanian is studying two promising genetic avenues for addressing heart failure, a massive global health burden in need of innovative treatments.
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Gladstone Institutes @gladstoneinst.bsky.social · 25/09/2026
Happy Research Administrator Day! Today we’re celebrating the people that make discovery possible at Gladstone. Your work creates the support our scientists need to pursue new ideas and advance their research. Thank you for everything you do behind the scenes to support our our science.
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Gladstone Institutes @gladstoneinst.bsky.social · 23/09/2026
🎉 It's Postdoc Appreciation Week, and we're celebrating the talented scientists who bring so much to our research and community. Postdocs are helping shape the future of science, and we're proud to support them as they grow into the next generation of scientific leaders.
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Gladstone Institutes @gladstoneinst.bsky.social · 22/09/2026
Ayush Midha, a graduate student in the Jain Lab, is uncovering how the body adapts when oxygen runs low—work that has surprising ties to cancer and fertility.
gladstone.org
Meet Gladstone: Ayush Midha
Ayush Midha, a graduate student in the Jain Lab, studies how the body's metabolism adapts to low oxygen—work that's uncovered backup energy pathways, potential fertility treatments, and a link between...
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Gladstone Institutes @gladstoneinst.bsky.social · 20/09/2026
Science is hard — failure is part of the process. Gladstone's Lexi Schneider explains why a strong support system (and hobbies outside the lab!) are just as essential to good science as the experiments themselves
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Gladstone Institutes @gladstoneinst.bsky.social · 20/09/2026
🚨 🚨 NEW PUBLICATION 🚨 🚨 "Secreted ORF8 reprograms macrophages to enhance SARS-CoV-2 infection of lung epithelial cells" @theottlab.bsky.social @ucsanfrancisco.bsky.social
science.org
Secreted ORF8 reprograms macrophages to enhance SARS-CoV-2 infection of lung epithelial cells
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily targets the respiratory epithelium, yet severe disease features diffuse lung injury and hyperinflammatory syndromes driven by dys...
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Gladstone Institutes @gladstoneinst.bsky.social · 18/09/2026
A new discovery reveals how a SARS-CoV-2 protein reprograms immune cells to accelerate viral spread—and points to a new strategy for therapeutic intervention.
gladstone.org
How a Single Viral Protein Hijacks Immune Cells to Supercharge COVID-19 Infection
A new discovery reveals how a SARS-CoV-2 protein reprograms immune cells to accelerate viral spread--and points to a new strategy for therapeutic intervention.
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Gladstone Institutes @gladstoneinst.bsky.social · 17/09/2026
Congrats to Gilbert Herrera who was named the inaugural Ellen & Bernard Marson Fellow! Herrera is making key discoveries about how immune cells can fight cancer more effectively.
gladstone.org
Rethinking ‘Exhausted' T Cells: Gilbert Herrera Named Inaugural Ellen & Bernard Marson Fellow
The fellowship provides three years of funding for graduate students pursuing groundbreaking immunology research.
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Gladstone Institutes @gladstoneinst.bsky.social · 17/09/2026
Gladstone researcher Nevan Krogan says the new autism research provides an important roadmap for understanding autism and identifying potential treatments.
cnn.it
Largest ever ‘map' of autism may hold clues for new targeted therapies | CNN
Scientists are getting a step closer to understanding exactly how autism develops in the brain – and what might work to treat it.
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Gladstone Institutes @gladstoneinst.bsky.social · 14/09/2026
Jun Takahashi was selected for pioneering the translation of induced pluripotent stem (iPS) cell biology into regenerative therapies for Parkinson’s disease, culminating in the world’s first clinical approval for iPS cell-derived cell transplantation. Read more: bit.ly/3VdWRlo
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Gladstone Institutes @gladstoneinst.bsky.social · 11/09/2026
Nevan Krogan discusses how researchers are connecting hundreds of autism-linked genes to the proteins they affect, helping identify common biological pathways that could lead to new treatments.
n.pr
Scientists map the interactions of key proteins linked with profound autism
After more than a decade, UCSF scientists have mapped around 100 varied genes associated with profound autism to a smaller set of biological pathways, offering a promising path for developing drugs.
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Gladstone Institutes @gladstoneinst.bsky.social · 10/09/2026
🎧 Listen to this story 🎧 An unprecedented map of 22 million immune cells provides the functional rulebook for virtual biology and next-generation immunotherapies.
open.spotify.com
Scientists Decode Gene Circuits of Human Immunity, Fueling New Era of Disease Research
Gladstone Audio News · Episode
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Gladstone Institutes @gladstoneinst.bsky.social · 09/09/2026
AI didn't just join biomedical research at Gladstone—it's being built here. From Geneformer to the "thinking microscope," our scientists are using AI to find cures faster.
gladstone.org
How AI Is Accelerating Life-Saving Discovery
Gladstone scientists are developing new AI tools that promise to revolutionize how science is done and lead to new treatments for the most devastating diseases.
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Gladstone Institutes @gladstoneinst.bsky.social · 08/09/2026
Scientists just stress-tested genes across 22 million human immune cells—using real cells from real donors, not lab models. Gladstone's Emma Dann & Ronghui Zhu break down why this massive new dataset could reshape cancer immunotherapy and autoimmune treatment.
gladstone.org
Science in Seconds | An Unprecedented Map of Human Immune Cells
In this video, Gladstone scientists Emma Dann and Ronghui Zhu explain how their new study offers a powerful framework for designing cancer immunotherapies and treating autoimmune conditions.
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Gladstone Institutes @gladstoneinst.bsky.social · 07/09/2026
The AI model behind this heart disease breakthrough? Geneformer — developed at Gladstone by Christina Theodoris' lab. Researchers used it to predict that patients with MYH7 and TTN mutations could benefit from a gene therapy that already reversed cardiomyopathy in mice.
insideprecisionmedicine.com
Gene Therapy Could Reverse Genetic Heart Disease, Spare Children from Transplants
A gene therapy could restore heart function in over 25% of children born with mutations that cause cardiomyopathy.
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Gladstone Institutes @gladstoneinst.bsky.social · 04/09/2026
Published in Cell, an unprecedented map of 22 million immune cells provides the functional rulebook for virtual biology and next-generation immunotherapies. The massive dataset stands as the largest contribution yet to Biohub Billion Cells Project. Read more: bit.ly/3SQzaPc
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Gladstone Institutes @gladstoneinst.bsky.social · 04/09/2026
Meet Lexi Schneider from the Yang Lab! She's developing a groundbreaking tool called TORCH to help scientists understand how the brain and body talk to each other—something that's been notoriously hard to study.
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Reposted by Gladstone Institutes
Biohub @biohub.org · 28/08/2026
This is the largest dataset contributed to the Billion Cells Project to date. It is an important step toward the scale and coordination needed to build the Virtual Biology Initiative.
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Reposted by Gladstone Institutes
Benoit Bruneau @benoitbruneau.bsky.social · 03/09/2026
fantastic and tremendously insightful review on fibrosis by my @gladstoneinst.bsky.social colleagues Michael Alexanian and Deepak Srivastava www.cell.com/action/showP...
cell.com
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Gladstone Institutes @gladstoneinst.bsky.social · 01/09/2026
A microscope that never sleeps, runs thousands of experiments at once, and learns from every result in real time. Steven Finkbeiner breaks down the AI-powered "thinking microscope" racing to crack Alzheimer's and ALS.
commonwealthclub.org
Giving Scientists Superpowers: How an AI-Powered “Thinking Microscope” Is Fast-Tracking Medical Breakthroughs
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Gladstone Institutes @gladstoneinst.bsky.social · 31/08/2026
Scientists just stress-tested genes across 22 million human immune cells — using real cells from real blood donors, not lab models. Gladstone's Emma Dann & Ronghui Zhu break down why this massive new dataset could reshape cancer immunotherapy and autoimmune treatment.
youtube.com
Science in Seconds | An Unprecedented Map of Human Immune Cells
YouTube video by Gladstone Institutes
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Gladstone Institutes @gladstoneinst.bsky.social · 29/08/2026
Could vaccines help keep treat cancer? In August, a late-stage clinical trial of a personalized mRNA vaccine for melanoma showed promising results. At Gladstone, researchers are working toward a future where therapeutic cancer vaccines are effective, accessible, and available to more patients.
youtube.com
The Promise of Cancer Vaccines: Can Vaccines Help Treat Cancer?
YouTube video by Gladstone Institutes
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Gladstone Institutes @gladstoneinst.bsky.social · 28/08/2026
An unprecedented map of 22 million immune cells provides the functional rulebook for virtual biology and next-generation immunotherapies. @ucsanfrancisco.bsky.social @marsonlab.bsky.social @stanford.edu @biohub.org @cp-cell.bsky.social @10xgenomics.bsky.social
gladstone.org
Scientists Decode Gene Circuits of Human Immunity, Fueling New Era of Disease Research
An unprecedented map of 22 million immune cells provides the functional rulebook for virtual biology and next-generation immunotherapies.
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Gladstone Institutes @gladstoneinst.bsky.social · 28/08/2026
A group of scientists, led by Gladstone Investigator Nevan Krogan, studied 100 autism risk genes and found that many patient-derived mutations disrupt core biological processes—a discovery that opens new avenues for future interventions. @qbi-ucsf.bsky.social
qbi.ucsf.edu
QBI - The Molecular Map of Autism: A Road to Potential Drug Targets
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Reposted by Gladstone Institutes
Benoit Bruneau @benoitbruneau.bsky.social · 27/08/2026
Phenomenal paper from our @gladstoneinst.bsky.social and @ucsanfrancisco.bsky.social colleagues on protein-protein interactions of autism-related proteins. www.science.org/doi/10.1126/...
science.org
Autism mutations rewire protein interaction networks to drive neurodevelopmental pathology
Systematic mapping of protein-protein interaction (PPI) networks and determining how causal mutations rewire them in autism spectrum disorder (ASD) provide a powerful framework for uncovering disease ...
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Gladstone Institutes @gladstoneinst.bsky.social · 26/08/2026
Michael Alexanian (@michaelalexanian.bsky.social ) is studying two promising genetic avenues for addressing heart failure, a massive global health burden in need of innovative treatments.
gladstone.org
Ask a Scientist: Can We Turn Off the Molecular Switches That Cause Heart Failure?
Michael Alexanian is studying two promising genetic avenues for addressing heart failure, a massive global health burden in need of innovative treatments.
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Gladstone Institutes @gladstoneinst.bsky.social · 26/08/2026
Shinya Yamanaka is ranked number 2 in Unfiltered's list of the most credible scientific voices in longevity.
unfilteredonline.com
Who are the most credible voices in longevity?
The most credible voices in longevity are mostly not the most visible ones. Of the 100 people ranked in the Unfiltered Longevity 100 for 2026, 38 are working scientists whose standing rests on peer-reviewed output, institutional position and replication...
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Gladstone Institutes @gladstoneinst.bsky.social · 25/08/2026
It's been 20 years since Shinya Yamanaka first discovered induced pluripotent stem cells (iPS) cells. Watch this animated short to learn more about how iPS cells work and how scientists use them in the lab.
youtube.com
Celebrating 20 Years of iPS Cells │What Are iPS Cells?
YouTube video by Gladstone Institutes
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Gladstone Institutes @gladstoneinst.bsky.social · 25/08/2026
Shinya Yamanaka is featured on the cover of TIME, reflecting on the 20-year journey of his groundbreaking iPS cell discovery and its potential to transform human health.
time.com
Shinya Yamanaka Made Cells Young Again. Can That Reverse Aging?
Twenty years after his Nobel-winning discovery, doctors are using Yamanaka's cell-reprogramming breakthrough to treat real patients—and address aging itself.
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Gladstone Institutes @gladstoneinst.bsky.social · 24/08/2026
Meet Lexi Schneider, a PhD student who develops new technologies to help better understand the blood brain barrier.
gladstone.org
Meet Gladstone: Lexi Schneider
Meet Lexi Schneider, a PhD student using innovative technology to uncover how the blood-brain barrier communicates.
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Gladstone Institutes @gladstoneinst.bsky.social · 24/08/2026
Scientists in the labs of Benoit Bruneau, Katie Pollard, and Deepak Srivastava uncovered a mechanism showing how small reductions in protein levels can disrupt DNA’s three-dimensional structure and lead to disease.
scitechdaily.com
A Single Faulty Gene Copy Can Unravel the Heart's DNA
By studying a gene associated with congenital heart defects, scientists uncovered a mechanism showing how small reductions in protein levels can disrupt DNA's three-dimensional structure and lead to disease.
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Gladstone Institutes @gladstoneinst.bsky.social · 23/08/2026
Using a new screening platform they developed, scientists at Gladstone and UCSF uncovered gene edits that enhance CAR-T cells’ ability to infiltrate and eliminate solid tumors. Learn more: bit.ly/4qtsjrw
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Gladstone Institutes @gladstoneinst.bsky.social · 23/08/2026
Congratst to Gladstone postdoc Stephanie Gaglione, who was named a Timmerman Traverse Fellow. Stephanie uses technologies to comprehensively profile the antigens displayed by virally-driven cancers, with a focus on targets that provoke an immune system response.
damonrunyon.org
Damon Runyon Cancer Research Foundation awards $4.2 million to exceptional early-career scientists | New Discoveries
The Damon Runyon Cancer Research Foundation has named 14 new Damon Runyon Fellows, brilliant postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading s...
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Gladstone Institutes @gladstoneinst.bsky.social · 22/08/2026
Gladstone researchers led a study showing that human stem cell-derived neurons can integrate into damaged spinal cords and improve breathing in injured rats—an encouraging step toward cell-based treatments for spinal cord injuries.
scholarpeer.com
Human Neurons Wire Into Rat Spinal Cords and Bolster Breathing
Engineered spinal interneurons grown from human stem cells survived inside injured rats, took input from the brainstem and passed signals on to the diaphragm, though every animal needed daily immunosu...
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Gladstone Institutes @gladstoneinst.bsky.social · 22/08/2026
Shoutout to Gladstone postdocs Jingya Qiu and Adam Weiner who were named Cancer Research Institute Immuno-Informatics Postdoctoral Fellows!
cancerresearch.org
The Future Starts Here: Meet the 2025–2026 Postdoctoral Fellows - Cancer Research Institute
Meet the FY2025-2026 CRI Irvington and Immuno-Informatics Postdoctoral Fellows, the next generation of scientists helping push the field of cancer immunotherapy forward.
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Gladstone Institutes @gladstoneinst.bsky.social · 21/08/2026
Shinya Yamanaka reflects on the 20th anniversary of the discovery of iPS cells and the field’s progress toward clinical therapies.
nature.com
A revolutionary stem-cell therapy must proceed responsibly to achieve its full potential
It is 20 years since induced pluripotent stem cells shook biomedicine. Public trust must be retained now that clinical trials are well under way.
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Gladstone Institutes @gladstoneinst.bsky.social · 21/08/2026
Scientists from across the NOMIS community gathered in Switzerland for the inaugural NOMIS Fellows Symposium.
gladstone.org
NOMIS-Gladstone Fellows Forge Global Connections Through Bold Science
Scientists from across the NOMIS community gathered in Switzerland for the inaugural NOMIS Fellows Symposium.
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Gladstone Institutes @gladstoneinst.bsky.social · 20/08/2026
What if we could test thousands of genetic changes in seconds? Gladstone scientist Katie Pollard and her team are using AI models to predict how changes in DNA could affect cells—helping researchers explore possibilities that would be impossible to test one by one in the lab.
youtube.com
How AI Is Speeding Up the Search for Genetic Discoveries
YouTube video by Gladstone Institutes
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Reposted by Gladstone Institutes
Benoit Bruneau @benoitbruneau.bsky.social · 19/08/2026
measured editorial on the clinical promise of iPS cells, 20 years after their discovery. Featuring my @gladstoneinst.bsky.social colleagues Shinya Yamanaka and Deepak Srivastava www.nature.com/articles/d41...
nature.com
A revolutionary stem-cell therapy must proceed responsibly to achieve its full potential
It is 20 years since induced pluripotent stem cells shook biomedicine. Public trust must be retained now that clinical trials are well under way.
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Gladstone Institutes @gladstoneinst.bsky.social · 20/08/2026
A growing body of research suggests that subtle seizure activity in the brain may be linked to cognitive decline and dementia. Gladstone’s Lennart Mucke has spent decades studying these connections, including how abnormal brain activity can contribute to memory loss in Alzheimer’s disease.
nytimes.com
The Little-Known Link Between Dementia and Epilepsy (Gift Article)
After he was diagnosed with “silent” epileptic seizures, doctors were able to treat his memory loss and confusion.
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Gladstone Institutes @gladstoneinst.bsky.social · 19/08/2026
Using a new screening platform they developed, scientists at Gladstone and @ucsanfrancisco.bsky.social uncovered gene edits that enhance CAR-T cells’ ability to infiltrate and eliminate solid tumors. Read more about this recent study: bit.ly/4qtsjrw
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Gladstone Institutes @gladstoneinst.bsky.social · 18/08/2026
🚨 NEW PUBLICATION 🚨 "Virus-like particles enable targeted gene engineering and pooled #CRISPR screening in primary human myeloid cells" @juliacarnevale.bsky.social @ucsanfrancisco.bsky.social @natbiotech.nature.com
go.nature.com
Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells - Nature Biotechnology
Primary human myeloid cells are efficiently edited using virus-like particles.
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Gladstone Institutes @gladstoneinst.bsky.social · 18/08/2026
Can we reprogram aging? Shinya Yamanaka’s discovery that mature cells can be reset to an earlier state transformed our understanding of cellular identity. Now, scientists are asking whether that same principle could help rejuvenate aging cells.
nationalgeographic.com
Are We on the Brink of Ending Aging?
Secret science. Billionaire backers. Inside the wild quest to turn growing old into a thing of the past.
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Gladstone Institutes @gladstoneinst.bsky.social · 18/08/2026
We're taking a closer look at how vaccines help protect us from disease. Kim Dam explains how vaccines train the immune system to recognize a pathogen, build immune memory, and respond when it encounters the real thing.
youtube.com
How Vaccines Train the Immune System—and What’s Next
YouTube video by Gladstone Institutes
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Gladstone Institutes @gladstoneinst.bsky.social · 17/08/2026
Scientists at Gladstone and UCSF developed a method to genetically edit myeloid cells, immune cells that act as the body’s first responders. @ucsanfrancisco.bsky.social @juliacarnevale.bsky.social @marsonlab.bsky.social
gladstone.org
New Toolkit Turns Macrophages Into Better Cancer Fighters
Gladstone and UCSF scientists developed a method to genetically edit myeloid cells, immune cells that act as the body's first responders.
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Reposted by Gladstone Institutes
Julia Carnevale @juliacarnevale.bsky.social · 17/08/2026
Another major milestone for my lab - our second paper is out today in Nature Biotechnology! Co-led by Pascal Devant & Hyuncheol Jung, with @marsonlab.bsky.social: www.nature.com/articles/s41...
nature.com
Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells - Nature Biotechnology
Primary human myeloid cells are efficiently edited using virus-like particles.
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Gladstone Institutes @gladstoneinst.bsky.social · 17/08/2026
The FDA has approved the first mRNA-based flu vaccine, offering a potential path to faster, more adaptable vaccines that can better match circulating strains. Nadia Roan weighs in on the new vaccine.
sfchronicle.com
There’s a new flu shot for adults 50 and older. Should you get it?
The first mRNA flu vaccine is expected to arrive for the 2026-27 season, giving older adults another option alongside conventional flu shots.
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Reposted by Gladstone Institutes
Julia Carnevale @juliacarnevale.bsky.social · 13/08/2026
Very excited to share my lab's first major paper, led by postdoc Qi Liu @gladstoneinst.bsky.social @ucsanfrancisco.bsky.social executing the first ever genome-wide in vivo screens for genetic modifications to enhance human T cell therapies for solid tumors. www.nature.com/articles/s41...
nature.com
In vivo genome-wide CRISPR screens of human T cells in solid tumours - Nature
An in vivo model that is able to recover human T cells from solid tumours can identify targets to help improve CAR T cell antitumour activity.
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Reposted by Gladstone Institutes
Marson Lab @marsonlab.bsky.social · 13/08/2026
A truly incredible first paper from Julia's lab finally out in @nature.com! Just one of many big things to come from her group. @gladstoneinst.bsky.social @ucsanfrancisco.bsky.social @parkerici.bsky.social
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Stacie Dodgson, PhD @staciedodgson.bsky.social · 13/08/2026
So happy to have contributed to this work - check out the first (of many) exciting papers from the Carnevale lab, now out in Nature! @gladstoneinst.bsky.social @ucsfcancer.bsky.social @ucsanfrancisco.bsky.social @parkerici.bsky.social
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