The actin-related protein 2/3 (Arp2/3) complex is a central nucleator of branched actin filaments, essential for numerous cellular processes. Using superresolution imaging, we demonstrate that Arp2/3 ...

Neurons rely on localized protein synthesis to rapidly adapt synaptic function to activity, yet how dendritic translation regulates mitochondrial remodeling during synaptic plasticity remains poorly u...

Cell-state diversity drives tissue adaptability, repair, and disease resilience, but capturing this complexity is a challenge. Current approaches rely on transcriptional profiling and overlook organel...

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Disruptions in inter-organelle contacts result in membrane lipid homeostasis defects that ultimately impair cellular function and viability. Yet, essential responses to membrane lipid imbalances remai...

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Sensing and integration of mechanical forces in eukaryotic cells have largely been attributed to the plasma membrane and the nucleus. Here, we identify the endoplasmic reticulum (ER) as an autonomous ...

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Heffner et al. show that ANXA11 and CHMP2B, proteins encoded by ALS- and FTD-risk genes, are sequentially recruited to sites of plasma membrane damage. Membrane repair involves ANXA11-positive plug fo...

Our grants support and encourage the sharing of knowledge throughout the community by facilitating international collaboration, event attendance and the organisation of scientific meetings, conference...

Mitochondria (Mito) engage in extensive communication with other organelles through membrane contacts. Perturbed mitochondria–organelle interaction...

Downes et al. use in situ cryo-electron tomography and super-resolution fluorescence microscopy to define ER exit site architecture in unperturbed human cells. They visualize ribosome-exclusion zones ...

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Canadian Association for Neuroscience

BDNF promotes axon-regenerative gene expression, RNA metabolism, and kinase signaling in motor neurons.

Sponsorship of postdoctoral researchers interested in applying for career development fellowships to establish research independence.