Sign in

Katie Downes

@dr-downes.bsky.social
611 followers 552 following 19 posts

Post Doc @ Francis Crick Institute and UCL - COPII, CryoCLEM, cats, mammalian secretory pathway, image analysis

PostsRepliesMedia
Reposted by Katie Downes
MFS 2025 Conference @msf25.bsky.social · 26/09/2025
🔬At #MFS25, Giulia Zanetti from @TheCrick unveiled the molecular architecture of the early secretory pathway using cryo-ET & super-resolution microscopy resolving the debate on COPII vesicles and mapping ER-to-Golgi transport in human cells. 🔗https://mfs2025.com/
081
Reposted by Katie Downes
Ben Engel @cellarchlab.com · 13/08/2019
We're looking for an awesome computational #postdoc to join our group @PioneerCampus. You'll explore native cells with #cryoET, get long-term funding (5+ years), and live in Munich! For more info, see our new Cell Architecture Lab website:...
21110
Katie Downes @dr-downes.bsky.social · 20/08/2025
I attended this course last year and cannot recommend it enough!
000
Katie Downes @dr-downes.bsky.social · 30/07/2025
Very excited to announce that my first, first author paper, is now on BioRxiv! In this paper we unambiguously show #COPII coated vesicles in unperturbed human cells for the very first time!! Make my day and check it out! www.biorxiv.org/content/10.1... #Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬
610031
Reposted by Katie Downes
Lorenz Lamm @lorenzlamm.bsky.social · 25/04/2025
🦠🧠 MemBrain update! 🧠🦠 We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics. 🔗 Preprint: doi.org/10.1101/2024... 🔗 Code: github.com/CellArchLab/... 🧵(1/6) #TeamTomo
28034
Katie Downes @dr-downes.bsky.social · 28/03/2025
Ready for BBCs #AQuestionofScience here @crick.ac.uk 🔬🧬🥼🧪🦠
010
Reposted by Katie Downes
Misha Kudryashev @mishakudryashev.bsky.social · 28/03/2025
We are looking for a PhD student/Postdoc to develop methods of cryo-ET and/or study the structure and function of membrane proteins. Great team at the MDC in Berlin. It's a broad call, please apply and share! jobrxiv.org/job/max-delb...
jobrxiv.org
PhD /Postdoc in In Situ Structural Biology by Cryo-ET
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
02013
Katie Downes @dr-downes.bsky.social · 25/03/2025
I am thrilled to announce my and @giuliazanetti.bsky.social's latest review "Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway" in @natrevmcb.bsky.social with @springernature.com. Check it out here! rdcu.be/eeY1J #COPII #CryoEM #TeamTomo #MembraneTrafficking #ERES
rdcu.be
Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway
Nature Reviews Molecular Cell Biology - Coat protein complex II (COPII) subunits assemble to form membrane transport carriers at ER exit sites, thereby concentrating secretory cargoes and...
04820
Katie Downes @dr-downes.bsky.social · 07/03/2025
Does anyone have any idea what this wavey guy is? 🌊🌊🌊🌊#TeamTomo #CryoET In-situ tomogram of milled RPE-1 cells.
1194
Reposted by Katie Downes
Ishier Raote @ishier.bsky.social · 15/01/2025
Exciting news! #MembraneTrafficking online seminars with @felixmendu.bsky.social @franbottanelli.bsky.social and me are back! Check the spectacular Jan-April 2025 lineup. Details (Zoom links, calendar invites) on the mailing list, Slack group & website: felixcampelo.wixsite.com/membranetraf...
05335
Katie Downes @dr-downes.bsky.social · 28/11/2024
Lets play... What Am I Looking At?? Low mag tomogram of milled RPE-1s. Any guesses of whats going on here? #TeamTomo Prize? idk... bragging rights? The feeling of superiority? I'll collect a high mag tomo tomorrow, so the answer may actually be revealed! (mysteries mysteries mysteries).
291
Reposted by Katie Downes
Ferdos Abid Ali @abidalilab.bsky.social · 27/11/2024
If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪
This scheme shows the cargo adaptor FHF in the middle with arrows pointing to distinct microtubule and actin-based motors (dynein-dynactin, KIFC1, KIF1C and myosins V, IX and X as well as Tropomyosin 1). It also shows a link to Rab5 marked early endosomes. The hypothesis is that FHF coordinates multi motor binding at the early stages of endocytosis. The PhD project would address the hierarchy of motor binding and how these motors coordinate to allow the newly formed vesicle to transition from the actin to MT cytoskeletal network.
15430
Reposted by Katie Downes
MRC-LMB Cell Biology Division @cellbiol-mrclmb.bsky.social · 12/11/2024
This year’s UK Membrane Trafficking Meeting is on Dec 16th at King’s College London (Guy’s Campus, London Bridge). Registration closes 9th December. Sign up is here. estore.kcl.ac.uk/conferences-... Thanks go to @J_Cell_Sci for sponsoring student/postdoc prizes!
estore.kcl.ac.uk
UK Membrane Trafficking Meeting 2024 | King's College London eStore
Registration for the 2024 UK Membrane Trafficking Meeting, held at KCL.  Registration per person, to include sandwich lunch and coffee breaks and even
01612
Reposted by Katie Downes
Ishier Raote @ishier.bsky.social · 11/11/2024
📢 Announcing the Membrane Trafficker Starter Pack! This list highlights researchers advancing our understanding of membrane trafficking pathways. This is just a beginning—help expand the list! go.bsky.app/J9GvL3S
93328
Katie Downes @dr-downes.bsky.social · 26/11/2024
Latest paper from our lab out now! #TeamTomo #CryoET www.nature.com/articles/s41...
nature.com
Cryo-electron tomography reveals how COPII assembles on cargo-containing membranes - Nature Structural & Molecular Biology
The authors reconstituted coat protein complex II vesicles from native membranes and used cryo-electron tomography and subtomogram averaging to reveal the arrangement of inner and outer coat layers on...
08022
Katie Downes @dr-downes.bsky.social · 22/11/2024
Hmmm something tells me #cryoCARE didn't quite work...🤔 #CryoET #TeamTomo
190