Comparative analysis of experimentally defined and computationally predicted mitoproteomes prioritizes candidate targets for protozoan diseases and predicts an ancestral mitochondrion with aerobic and...

Phosphorylation is a pervasive mitochondrial protein post-translational modification, yet the extent of its influence over mitochondrial functions remains unclear. To identify dynamic mitochondrial ph...

The molecular function of many mitochondrial proteins remains unknown. Here, the authors present MitoMatch, an AlphaFold Multimer-based compendium of mitochondrial protein interactions that links orph...

Neurons rely on localized protein synthesis to rapidly adapt synaptic function to activity, yet how dendritic translation regulates mitochondrial remodeling during synaptic plasticity remains poorly u...

Most biological processes are dynamic, yet experimental methods predominantly rely on steady-state measurements to investigate their underlying mechanisms. RNA localization is a fundamental aspect of ...

Mitochondrial DNA (mtDNA) encodes core subunits of the oxidative phosphorylation machinery, and its expression is spatially organized, with the genome packaged into nucleoids around which transcriptio...

The mitochondrial inner membrane complexes TIM23 and TIM22 mediate distinct protein topogenesis functions in polypeptide import. The authors reveal their mechanistic overlap in topogenic sequence reco...

Mitochondrial cristae are essential for respiration, yet the molecular basis of how the high curvature of these membrane folds is maintained remains unclear. Using structure prediction tools and multi...

Cells owe a lot to their mitochondria—to their many mitochondria. Recent discoveries and emerging technologies point to functional distinctions within that population. We asked a group of researchers ...

Mitochondrial dysfunction features prominently in tauopathies. The mechanistic link between tau and mitochondria remains uncertain. Li et al. show that tau enters mitochondria and interacts with compl...

The cellular distribution of mitochondria in response to stress and local energy needs is governed by the relative activities of the microtubule-based molecular motors kinesin and dynein. The mechanis...

Proteomic and transcriptomic profiling on hiPSC-derived midbrain dopaminergic neurons with pathological α-synuclein burden reveals defective Sec61A interactions and co-translational translocation of E...

Mitochondria perform diverse metabolic and signaling functions, yet how these activities are spatially organized within the mitochondrial network of cells remains poorly understood. Organelle contact ...

Cellular lipid homeostasis requires mechanisms that detect subtle changes in lipid abundance and trigger rapid, coordinated responses. The INSIG/SCAP/SREBP2 pathway provides a central feedback system ...

Lipids are fundamental organizers of biological membranes, yet visualizing lipid species within subcellular organelles has remained beyond experimental reach. Lennartz et al. introduce Lipid-correlati...

Researchers identify mitochondrial plaques, a previously unrecognized and highly acidic mitochondria-based pathological structure in Alzheimer’s disease, and demonstrate that they result from the dual...

In this study, microgravity was found to disrupt mitochondrial translation through inhibition of laminin–integrin signaling and the downstream pathway, which is usually activated by mechanical stress.

Mitochondrial function depends on the maintenance of its genome, and disruptions in copy number and distribution are hallmarks of mitochondrial disorders. Mitochondrial DNA (mtDNA) replication is spat...

Mitochondria convert nutrients into ATP through coordinated molecular machines and metabolic pathways. Here, the authors show that ATP synthase contacts TCA cycle enzymes in mouse heart and that defec...

Lang et al. use larval zebrafish neurons to show that the axonal retrograde transport of mitochondria is required to activate mitochondrial biogenesis through NAD + /Sirt1/Estrogen-related receptor me...

Mitochondria interact directly with the nuclear pore complex via VDAC1–RANBP2 binding to sustain nuclear ATP levels.

Mitochondria are classically viewed as a uniform ATP-producing network; however, a growing body of evidence suggests distinct subpopulations exist within tissues and even single cells. Here, I highlig...

TDP-43 localization is disrupted in ALS and FTD. Here, authors find that TDP-43 oxidation via mitochondrial OXPHOS mediates its localization to RNA granules, regulating RNA granule-mitochondria contac...

The adult heart grows by the addition of sarcomeres along the length or width of individual cardiomyocytes, yet how directional growth is spatially coordinated remains unclear. We found that microtubu...

Nature Metabolism, Published online: 13 May 2026; doi:10.1038/s42255-026-01513-zThis study describes a novel mechanism of calcium control of metabolism found in the mitochondrial intermembrane space that is entirely independent of matrix Ca2+ uptake.

Nature Metabolism, Published online: 08 May 2026; doi:10.1038/s42255-026-01532-wMetabolomic analysis of plasma from metformin-treated humans, together with mechanistic studies in mouse models, reveals that metformin selectively inhibits mitochondrial complex I in the intestinal epithelium. This mechanism unifies multiple clinical effects of metformin, including enhanced intestinal glucose use, improved postprandial glycaemic control and increased production of GDF15 and N-lactoyl-phenylalanine.

Using carbon tracing and functional experiments, Kafkia, Pladevall-Morera, et al. show that TCA cycle rewiring underlies mouse embryo implantation and the exit from naive pluripotency. In this context, pyruvate cycling enables timely cell-state transitions, while, coupled to it, reductive glutamine metabolism fuels the histone acetylation backbone.

Nature Human Behaviour, Published online: 01 May 2026; doi:10.1038/s41562-026-02466-9Scientific figures strongly influence how research findings are interpreted, yet guidance on figure design has largely focused on technical aspects of visualization. In this ‘How to’ Comment, I outline a practical strategy for creating figures that communicate clearly across audiences and scientific contexts.

SLC6A6 localizes to the inner mitochondrial membrane and mediates mitochondrial taurine import, which sustains mitochondrial tRNA modifications and cell growth.