The NGF/TrkA signaling axis is a central mediator of inflammatory and chronic pain, where injury-induced NGF binds and activates TrkA on nociceptive neurons to drive peripheral sensitization and persi...

Mitochondrial morphogenesis is a rapidly advancing area of research within cell biology, capturing the complexity of how these organelles change their shape,...

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This study reveals how cardiolipin governs mitochondrial morphology by modulating the activity of human OPA1 and how its replacement by monolyso-cardiolipin, as observed in Barth syndrome, impacts mitochondrial membrane-shaping mechanisms.

Primary Work Address: HHMI/Columbia University | Shadlen Lab--L5-003, New York, NY, 10027 Current HHMI Employees, click here to apply via your Workday account. The Howard Hughes Medical Institute (HHM...

Liu et al. find that long-chain acyl-coenzyme A activates two mitochondrial fission proteins, MiD49 and MiD51, by inducing their oligomerization. This activates their ability to stimulate DRP1 GTPase ...