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Pietro Fratta

@frattalab.bsky.social

UCL Queen Square Institute of Neurology and The Francis Crick Institute. RNA metabolism and novel translational approaches for ALS/MND, Kennedy's disease and neurodegen.

Posts Replies Media

Reposted by Pietro Fratta

Nicol Birsa @nicolbirsa.bsky.social · 18/06/2025

Very excited to share our latest preprint! We looked at loss and gain of function, innervation, reinnervation, and in vivo axonal transport in a FUS-ALS mouse model! www.biorxiv.org/content/10.1... @uclqsion.bsky.social @beccasimkin.bsky.social @andrewtosolini.bsky.social @frattalab.bsky.social

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Reposted by Pietro Fratta

Mike Fainzilber @mfainzilber.bsky.social · 16/05/2025

A 🧵 to walk those interested through this paper...

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Reposted by Pietro Fratta

Abraham Acevedo @acevedolab.bsky.social · 30/04/2025

Our new review on the challenges of modelling TDP-43 pathology in mice is just out: rdcu.be/ejZ5a As usual, together with Lizzy Fisher. Thanks to Jose Brito and @lucastaoro.bsky.social from the lab for putting the data together for the comprehensive tables.

rdcu.be

Challenges of modelling TDP-43 pathology in mice

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Pietro Fratta @frattalab.bsky.social · 06/04/2025

Something different from the lab! We need better ALS biomarkers to minimise size, duration and cost of trials. Muscle MRI could work as it reliably detects progressive atrophy, and correlates with muscle strength loss. @uclqsion.bsky.social @uclbrainscience.bsky.social jnnp.bmj.com/content/earl...

jnnp.bmj.com

Muscle MRI quantifies disease progression in amyotrophic lateral sclerosis

Background and objectives Quantitative and operator-independent biomarkers of disease progression are urgently needed in amyotrophic lateral sclerosis (ALS) research. We assess the potential of skelet...

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Reposted by Pietro Fratta

Polymenidou Lab @polylab.bsky.social · 28/03/2025

Happy to share our new study that was just published in Neuron! www.cell.com/neuron/fullt...

cell.com

Seeded aggregation of TDP-43 induces its loss of function and reveals early pathological signatures

TDP-43 pathology characterizes neurodegenerative diseases. Scialò et al. use in vitro-generated and patient-derived TDP-43 aggregates as seeds to show that seed-induced TDP-43 cytoplasmic aggregation ...

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