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Andrew Tosolini

@andrewtosolini.bsky.social
585 followers 514 following 11 posts

Senior researcher at The University of Queensland - Ngo and Steyn Labs. Schiavo Lab alumni. Interested in MND/ALS, motor neurons, NMJs, and of course axonal transport. Hobbies include the Socceroos, the Australian Cricket team and Chelsea FC.

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Andrew Tosolini @andrewtosolini.bsky.social · 28/09/2026
Really pleased for David and Chloe to see this published. Was a great collaboration #ALS #MND #SOD1 #metabolicdysfunction @uclqsion.bsky.social
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Reposted by Andrew Tosolini
Brain Communications @braincomms.bsky.social · 27/09/2026
Rhymes et al. report that ciliary neurotrophic factor selectively slows the retrograde transport of signalling endosomes in motor neurons in vivo, highlighting the specificity with which neurotrophic factors shape axonal transport and motor neuron connectivity. Read it at 👉https://buff.ly/jfwxif1
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Andrew Tosolini @andrewtosolini.bsky.social · 22/09/2026
🧠🔬 Delighted to share work led by Dr Ellie Rhymes. Using #IntravitalImaging of #NeurotrophicFactors, we show #CNTF selectively slows #AxonalTransport in motor neurons. Great collab with Schiavo lab & @jamessleigh.bsky.social @braincomms.bsky.social @uclqsneuromuscular.bsky.social
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Andrew Tosolini @andrewtosolini.bsky.social · 15/04/2026
Congrats to Jobert, Anna-Leigh, and Kai on showing how #BDNF amplifies #transcription, coordinates #RNA dynamics, and spatially regulates the #phosphoproteome. Beautiful cover art too! @jamessleigh.bsky.social @frattalab.bsky.social @uclqsion.bsky.social
science.org
Brain-derived neurotrophic factor coordinates neuron-intrinsic programs to enhance axonal regeneration in human motor neurons
BDNF promotes axon-regenerative gene expression, RNA metabolism, and kinase signaling in motor neurons.
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Andrew Tosolini @andrewtosolini.bsky.social · 09/02/2026
Recently published work lead by the very talented @dvillarroelc.bsky.social. Lots of work has gone in to this and I have enjoyed seeing this story develop over the years. Congrats to all! @jamessleigh.bsky.social @joburrito.bsky.social @frattalab.bsky.social @uclqsion.bsky.social #axonaltransport
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Andrew Tosolini @andrewtosolini.bsky.social · 15/10/2025
Do all #NTFs regulate #MotorNeuron axonal transport in vivo? Our new preprint shows they do not. #BDNF enhances (shorturl.at/siwFi), #CNTF slows, and #HGF, #NRTN & #proBDNF show no effect. #AxonalTransport regulation is selective, not universal. @jamessleigh.bsky.social @uclqsion.bsky.social
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Andrew Tosolini @andrewtosolini.bsky.social · 18/06/2025
A wonderful collaboration. Congratulations to @nicolbirsa.bsky.social & @beccasimkin.bsky.social and all the co-authors #axonaltransport #FUS #MND #ALS #NMJ
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Reposted by Andrew Tosolini
James N. Sleigh @jamessleigh.bsky.social · 30/05/2025
Our new paper in Neurobiology of Aging showing that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice: www.sciencedirect.com/science/arti... @dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social @uclqsion.bsky.social #aging
sciencedirect.com
Processivity and BDNF-dependent modulation of signalling endosome axonal transport are impaired in mice with advanced age
A healthy nervous system is reliant upon an efficient transport network to deliver essential cargoes throughout the extensive and polarised architectu…
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Andrew Tosolini @andrewtosolini.bsky.social · 06/05/2025
🚨New @biorxivpreprint.bsky.social collab b/w Fisher, Cunningham, Gilthorpe & Schiavo Labs. @mrcharwell.bsky.social @uclqsion.bsky.social @umeauniversitet.bsky.social Metabolic alterations in the absence of a detectable neuromuscular phenotype in novel humanised SOD1A4V mice. t.co/u01CG6ctTS
t.co
https://www.biorxiv.org/content/10.1101/2025.05.01.650597v1
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Reposted by Andrew Tosolini
James N. Sleigh @jamessleigh.bsky.social · 02/02/2025
In our latest pre-print, we show that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice: www.biorxiv.org/content/10.1... Well done team! @dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social et al. @uclqsion.bsky.social #aging
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Andrew Tosolini @andrewtosolini.bsky.social · 25/11/2024
A little about me! 🦋 With help from Scholar Goggler scholargoggler.com
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Reposted by Andrew Tosolini
Guillaume Jacquemet @guijacquemet.bsky.social · 11/11/2024
I will try to take on the challenge to highlight some of the cool bioimage analysis tools we use all the time. #BioimageTooloftheDay I will start with ijp-LaRoMe, a very nifty Fiji plugin that I use all the time to convert ROI to label images and vice versa github.com/BIOP/ijp-LaR...
github.com
GitHub - BIOP/ijp-LaRoMe: some useful function to get Label from ROIs and vice versa , and more!
some useful function to get Label from ROIs and vice versa , and more! - BIOP/ijp-LaRoMe
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Reposted by Andrew Tosolini
Scheiffele Lab @scheiffelelab.bsky.social · 17/11/2024
Looking forward to AXON2025 - mark your calendars
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