Alcohol’s brain effects are attributed to neurons, leaving microglial functional involvement untested. Paouri, Stanko, et al. show that microglia drive alcohol-induced sedation, motor impairment, and ...

Chen et al. use 7-Tesla fMRI to show that the human superior colliculus has modality-specific, depth-dependent activity prior to visual or somatosensory events, resembling its response to actual stimu...

Lung anthelmintic responses during hookworm infection are regulated by skin-derived γδ T cells.

Cryo-electron tomography (cryo-ET) resolves and quantifies an almost complete view of bacterial translation, revealing how gene expression machineries coordinate across the processes of transcription,...

Subiculum, the primary output structure of the hippocampus, remains an enigmatic structure in spatial processing. Here the authors reimagine subicular spatial responses as emerging from behaviour and ...

The authors present a novel channel rhodopsin variant with enhanced Ca2+ conductance in megakaryocytes and platelets.

Analysis of cellular recordings from five phylogenetically diverse species uncovers a conserved, multiscale organization of neuronal activity that resolves disparate theories of brain function. This h...

Objective To explain discrepant findings for fluoxetine's efficacy in three influential network meta-analyses (NMAs) of treatments for pediatric depression, which led to conflicting clinical recomme.....

Jo et al. show that transient OSKM induction generates two distinct liver progenitor-like cell populations with limited immune activation. Liver-targeted OSKM mRNA-LNPs induce hepatocyte dedifferentiation and enhance regeneration after acetaminophen-induced liver injury, supporting transient hepatic reprogramming as a strategy for inducing regenerative plasticity with therapeutic potential for acute injury.

Menopause is an important biological transition with up to 72 symptoms that shapes aging trajectories across organs and encompasses ~40% of the female lifespan. Although menopause awareness is increas...

Despite the variation in venom across the Bothrops snake genus, repurposed drugs demonstrated pan-species neutralisation in enzymatic, coagulation, and haemorrhage assays, highlighting their value as...

Vinsland et al. provide a single-cell and spatial transcriptomics atlas of postconceptional week 5–13 human meninges and perform comparative studies with meningioma data.

Cyclic oligonucleotide–based antiphage signaling systems (CBASS) are bacterial immune pathways evolutionarily related to cGAS-STING (cyclic GMP-AMP synthase–stimulator of interferon genes) in humans. ...

Endothelial cells instruct the early developmental program of human periosteum-derived callus organoids. Scalable organoid aggregates guide host-mediated regeneration through endochondral ossification, restoring critical-size skeletal defects.

Franch et al. show that human hippocampal neurons encode the meanings of the words we hear through distributed, context-sensitive population activity that mirrors some features of large language model...

Type 2 inflammation trains nerve- and airway-associated macrophages to confer disease tolerance against lethal influenza by limiting immunopathology and promoting tissue repair without enhancing viral...

Lennartz et al. evaluate lipid enrichment in clathrin-coated pits and observe that the differential lipid partitioning into clathrin-coated pits is largely driven by the lipid asymmetry of the plasma ...

Kage et al. report a novel phosphorylation-dependent interaction between INF2 and VAP proteins. Increased cytoplasmic calcium stimulates INF2 phosphorylation, which, in turn, allows VAP binding. The I...

Mutation of conserved prolines enhances correct pairing of light and heavy chains for bispecific IgG-like antibody production.

Among 16 patients with refractory neurologic autoimmune disorders, lentiviral CD19 CAR T-cell therapy was associated with manageable side effects, complete B-cell depletion, and preliminary clinica...

Human coronary hemodynamics for cardiac 3D ultrasound localization microscopy benchmarking, Reydet, Juliette, Dizeux, Alexandre, Haidour, Nabil, Tanter, Mickael, Pernot, Mathieu, Papadacci, Clement

Bacterial ribosomes can synthesize proteins encoded within their own RNA.

Li, Jihad and colleagues develop an organoid co-culture system, alongside patient tissue and mouse model analyses, to model, characterize and compare cellular interactions between epithelia and stroma...

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In one inbred strain of laboratory mice, late-life treatment with a GLP-1 drug extends lifespan. This effect might be more than just a consequence of calorie restriction.

Integron insertion sites engineered into counterselection markers allow large-scale and high-throughput capture of integron-encoded genes from genetically tractable bacteria or DNA samples.

Structures of a protein used to make crucial sugar-carrying lipids uncover a surprising reaction mechanism and a built-in brake that emerged during primate evolution.

Simultaneous imaging of premotor cortex and cerebellar granule cells in mice learning two skills in parallel shows that trajectories generalize in cortex but coherently reorient apart in granule cells, supporting generalization and separation between contexts.