Modern studies find that fluoxetine has lost its efficacy for children and can now be considered clinically equivalent to placebo.

Die Cochrane-Stiftung, die seit Jahren die Nutzen medizinischer Therapien untersucht, soll künftig nicht mehr staatlich gefördert werden.

Abstract. Introduction: It remains contested if rapid onset of affective symptoms during antidepressant tapering reflects pharmacological withdrawal effects or relapse of an underlying mental disorder...

Taxing the rich is absolutely essential to saving our economy and our democracy.Don't believe me? Look at this chart.

PsychiatryOnline.org is the platform for all American Psychiatric Association Publishing journals, DSM, and bestselling textbooks, as well as APA Practice Guidelines, and continuing medical education.

A commonly used antidepressant is likely to be unavailable in the UK until later this year. The Department of Health and Social Care has issued a tier 2 medium impact alert warning of supply shortage...

This case report presents a patient with no history of suicidal crisis who experienced 2 suicidal crises within 6 months, each directly following rapid discontinuation of venlafaxine.

A commonly used antidepressant is likely to be unavailable in the UK until later this year. The Department of Health and Social Care has issued a tier 2 medium impact alert warning of supply shortage...

A new solution to a very serious issue

A new empirical review published in the Journal of Law, Medicine & Ethics reports that pharmaceutical industry corruption is a structural, Legal scholar Marc A. Rodwin argues that ending widespread…

Independent audits of published clinical research for statistical errors, data inconsistencies, and research integrity violations.

The evidence challenges the assumption that lifelong antipsychotic treatment is necessary for most individuals with schizophrenia.

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The Ket-BD randomized clinical trial evaluates the efficacy, safety, and tolerability of adjunctive intravenous ketamine compared with midazolam for treatment-resistant bipolar I or II depression.

Lithium is a pharmacological agent with a well-established role in psychopharmacology. Interest in its “trace” doses as a potential nutrient has increased in the context of geochemical variability of ...

Coming to terms with small effects and large variation in treating common disorders

BackgroundReliable diagnosis is a cornerstone of medical practice, yet concerns about diagnostic reliability have long haunted psychiatry. In the 1970s, the ...

The growing use of the term “real-world evidence” (RWE) has introduced a classification of clinical research based on its perceived proximity to routine practice rather than its methodological charact...

You might have noticed: whenever Trump wants to detract the public from something embarrassing or criminal, he makes headlines by re-naming something. That seems to work quite well: for a day or two, the world is outraged by his moronic action. Yet, the public focus on the embarrassment or crime quickly returns, and Trump has

Objective Depressive symptoms frequently afflict individuals with Parkinson’s disease (PD). The current study was consequently conducted to determine the efficacy of low-dose intravenous esketamine in...

Ketamine and its enantiomer esketamine are efficacious in 30–35% of the patients with treatment-resistant depression (TRD). Increased serum brain-deri…

Close to two-thirds of the city’s residents commute by bike to school or work every day.

Despite the extensive use of selective serotonin reuptake inhibitors (SSRIs) for anxiety treatment worldwide, their neural mechanism of action remains…

Integrative psychotherapy is now the most common form of psychotherapeutic practice. Yet, research shows that early-career therapists often struggle to integrate diverse theoretical models in ways ...

Science is supposed to be self-correcting. But what happens when the journals entrusted to uphold this principle become its gatekeepers?