iiinova — where your digital self keeps evolving

Alexander Belyy @alexanderbelyy.bsky.social · 17h

Last week we had fun presenting our toxin research at the #EurekaScienceFestival at #ForumGroningen, together with Marloes Susan Eerelman and @dshatskiy.bsky.social . It was fantastic to see so many people interested in science, cryo-EM and toxin research! Thanks to the organizers!

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Reposted by Alexander Belyy

Reese Richardson @reeserichardson.bsky.social · 25/08/2026

A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵

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Reposted by Alexander Belyy

Wout Oosterheert @woutoosterheert.bsky.social · 28/10/2025

Are you excited to uncover the molecular mechanisms of actin filament assemblies that drive cell migration using cryo-EM? Only 1.5 week to apply for this exciting PhD position in my newly established lab at the Netherlands Cancer Institute in Amsterdam: www.werkenbijavl.nl/vacatures/ph...

werkenbijavl.nl

PhD Student – Structural Biology of Actin Filament Assemblies | Werken bij AVL

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Alexander Belyy @alexanderbelyy.bsky.social · 14/09/2025

In our new article, we show how P. aeruginosa, a major cause of chronic respiratory infections in #cysticfibrosis (CF), uses the Type VI Secretion System #T6SS and specific #toxins to eliminate competing bacteria www.cell.com/cell-reports... #cryoEM @dshatskiy.bsky.social @jakecolautti.bsky.social

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Alexander Belyy @alexanderbelyy.bsky.social · 04/09/2025

Thrilled to be one of 12 awardees of the prestigious #ERCStG from the LS1 panel this year! Over the next five years, we’ll study how intracellular bacterial pathogens #Listeria and #Shigella manipulate #actin to spread infection, with the aim of finding ways to stop them. Exciting times ahead!

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Max Fürst @maxfus.bsky.social · 20/05/2025

🚨 preprint 2️⃣ this month: our (purely experimental🧪) venture into #ChemBio We prouldy present: ADD-tagging of proteins (or "ADDing") —a super convenient enzymatic technique to install click chemistry handles on proteins. Led by superstar @wahyuwidodo.bsky.social www.biorxiv.org/content/10.1... A 🧵👇🏽

Overview of ADD-tagging including ADP-ribosyl cyclase (ADPRC)-catalysed dinucleotide substrate generation and two step chemoenzymatic labelling of target proteins with the flavin transferase ApbE, followed by click chemistry-based functional group attachment.

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Reposted by Alexander Belyy

Max Fürst @maxfus.bsky.social · 03/05/2025

If u ever had to depict proteins as schematics in papers, u know the dilemma: how to create a pretty “blob”? If structure ends up big & central, u’ll render it with PyMol et al, but for a truly schematic depiction u want a biorender-style icon, but for YOUR protein. Think I’ve finally found a way.

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Alexander Belyy @alexanderbelyy.bsky.social · 01/05/2025

#Pseudomonas aeruginosa destroys other #bacteria using #T6SS and its effectors during infection in #cysticfibrosis patients. Here, we determined the #cryo-EM #structure of the effector Ptx2, which depolarizes target bacterial membranes. Check it out! www.biorxiv.org/content/10.1...

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Journal of Cell Biology @jcb.org · 17/02/2025

Structure of the F-tractin-F-actin complex. A new study by Dmitry Shatskiy, Athul Sivan, Roland Wedlich-Söldner @uni-muenster.de, and Alexander Belyy @alexanderbelyy.bsky.social @unigroningen.bsky.social: buff.ly/3EIqAur #Cytoskeleton #StructuralBiology #Biochemistry #Actin

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Reposted by Alexander Belyy

Journal of Cell Biology @jcb.org · 10/02/2025

New: Using F-tractin to visualize #actin in living cells? Dmitry Shatskiy, Athul Sivan, Roland Wedlich-Söldner, and Alexander Belyy @alexanderbelyy.bsky.social determined the F-tractin-F-actin structure and showed that this probe is nearly identical to #Lifeact. buff.ly/3EIqAur #cytoskeleton

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Alexander Belyy @alexanderbelyy.bsky.social · 11/02/2025

Are you doing cell #biology? Then, let me guess, you likely stained #actin! Our @jcb.org article reveals the structure of the popular actin probe F-tractin in complex with F-actin and introduces an optimized version for better imaging! A thread! 👀👇 rupress.org/jcb/article/...

rupress.org

Structure of the F-tractin–F-actin complex | Journal of Cell Biology | Rockefeller University Press

This study reveals the structure of F-tractin, a widely used peptide for visualizing the actin cytoskeleton, and introduces an optimized version that minim

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Alexander Belyy @alexanderbelyy.bsky.social · 30/01/2025

If you think you know everything about enzymes, check this out, we have a surprise for you 😃

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