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Mac Shine

@macshine.bsky.social
3.1K followers 2.4K following 83 posts

Computational Neurobiologist from Sydney, Australia. shine-lab.org. Banner image from www.gregadunn.com.

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Reposted by Mac Shine
Borjan (Boki) Milinković @neuromorphicboki.bsky.social · 18/09/2026
📜 FINALLY OUT! 📜 In @imagingneurosci.bsky.social (@mitpress.bsky.social), myself, Lionel Barnett, @anilseth.bsky.social, Olivia carter, and @thomasandrillon.bsky.social, advance approaches of #multiscale #emergence and it's application to EEG across #conscious #states. Buckle up 👇 1/n
direct.mit.edu
Emergent multiscale organisation of neural dynamics fragments in anaesthesia
Abstract. Conscious experience depends on the coordinated activity of neural processes that span multiple scales: from synapses to whole-brain dynamics. A recently introduced measure, dynamical indepe...
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Reza Shadmehr @rezashadmehr.bsky.social · 28/07/2026
If an action results in error, each neuron requires an individualized teaching signal that guides change in its output. This is the credit assignment problem of learning. Are there neurons in the brain that can compute such a sophisticated teaching signal? Yes. www.biorxiv.org/content/10.6...
biorxiv.org
Climbing fibers encode the gradient of a loss function for the cerebellum
Neurons in the brain are often many synapses away from motoneurons, yet if a movement results in error, each distant neuron needs a teacher that considers its specific contribution to production of th...
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The Transmitter @thetransmitter.bsky.social · 09/06/2026
@macshine.bsky.social talks with @satra.bsky.social about the #OHBM2026 Abstract Atlas—a community-built tool that places every 2026 abstract inside the broader neuroscience landscape. Where does your work sit in the field? #neuroskyence www.thetransmitter.org/open-source-...
thetransmitter.org
Finding your place in neuroscience
A new tool places every OHBM 2026 abstract inside a semantic map of the neuroscience literature, so you can find your neighbors.
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OHBM Australia @ohbm-australia.bsky.social · 09/06/2026
🎉 Registration is now OPEN for the 2026 OHBM Australian Chapter Annual Meeting! 🇦🇺🧠🇦🇺 Get your ticket now! 🎟️🎟️🎟️ Registration: events.humanitix.com/ohbm-austral... 📝 Submit your abstract: docs.google.com/forms/d/e/1F... 🏆 Nominate a colleague (or yourself) for an award: ohbm-aus.github.io/awards/
events.humanitix.com
OHBM Australia Meeting 2026
Uniting the Australian human brain mapping community.
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The Transmitter @thetransmitter.bsky.social · 12/05/2026
@macshine.bsky.social talks with @melcooperphd.bsky.social about her new work showing that astrocytes—long dismissed as the brain’s housekeepers—are wired together in precise, long-range networks that remodel in response to experience. #neuroskyence www.thetransmitter.org/astrocytes/t...
thetransmitter.org
How a hidden network of astrocytes shapes the brain
Astrocytes are wired together in precise, long-range networks that remodel in response to experience, according to new research.
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The Transmitter @thetransmitter.bsky.social · 06/04/2026
@macshine.bsky.social talks with Mario Senden about his new project using AI-driven bibliometrics to map the structural organization of neuroscience across 25 years. The field it reveals is at once thriving and theoretically adrift. #neuroskyence www.thetransmitter.org/methods/what...
thetransmitter.org
What a bird’s-eye view of half a million papers reveals about neuroscience
New research uses artificial-intellligence-driven bibliometrics to map the structural organization of neuroscience across 25 years. The field it reveals is at once thriving and theoretically adrift.
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Alessandro Gozzi @gozziale.bsky.social · 05/03/2026
fMRI connectivity is dominated by recurring high-amplitude BOLD events (CAPs, QPPs) But what originates these events? Many think neuromodulation is the culprit. Our new work offers a simpler take: cortico-cortical dynamics alone can generate CAP-like events! doi.org/10.1371/journal.pcbi.1013995 🧵1/n
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Ashley Tyrer @ashleytyrer.bsky.social · 02/12/2025
I recently had the pleasure of chatting with @macshine.bsky.social as part of the OHBM Award Winner interview series; thanks for a great conversation! 🙏 Catch the interview here 👇
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PessoaBrain @pessoabrain.bsky.social · 11/10/2025
𝗔 𝗡𝗘𝗨𝗥𝗢𝗘𝗖𝗢𝗟𝗢𝗚𝗜𝗖𝗔𝗟 𝗣𝗘𝗥𝗦𝗣𝗘𝗖𝗧𝗜𝗩𝗘 𝗢𝗡 𝗧𝗛𝗘 𝗣𝗥𝗘𝗙𝗥𝗢𝗡𝗧𝗔𝗟 𝗖𝗢𝗥𝗧𝗘𝗫 By Mars and Passingham "Understanding anthropoid foraging challenges may thus contribute to our understanding of human cognition" Going to the top of the reading list! doi.org/10.1016/j.ne... #neuroskyence
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Mac Shine @macshine.bsky.social · 26/09/2025
random neuroimaging question: does anyone in bluesky-land have access to the loadings for neurosynth topics in schaefer 400 (yeo7) space? #neuroskyence @misicbata.bsky.social @richardfbetzel.bsky.social @borismontreal.bsky.social @sofievalk.bsky.social
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Tim Viney @vineytj.bsky.social · 15/09/2025
*New preprint from the lab* – “Granularity of thalamic head direction cells” doi.org/10.1101/2025... 🧠📈 🧪 1/11
doi.org
Granularity of thalamic head direction cells
Head direction signaling is fundamental for spatial orientation and navigation. The anterodorsal nucleus of the thalamus (ADn) contains a high density of head direction (HD) cells that process sensori...
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Paul Middlebrooks @braininspired.bsky.social · 10/09/2025
What changes and what stays the same as you scale from single neurons up to local populations of neurons up to whole brains? Michael and Mac @macshine.bsky.social on the systems approach to study brains across scales. braininspired.co/podcast/220/
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Mehrdad Kashefi @mkashefi.bsky.social · 06/09/2025
Excited to share my latest work with @jonathanamichaels.bsky.social @diedrichsenjorn.bsky.social & @andpru.bsky.social! We asked: How does the motor cortex account for arm posture when generating movement? Paper 👉 www.biorxiv.org/content/10.1... 1/10
biorxiv.org
Compositional neural dynamics during reaching
The complex mechanics of the arm make the neural control of reaching inherently posture dependent. Because previous reaching studies confound reach direction with final posture, it remains unknown how...
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Claire O'Callaghan @claireocallaghan.bsky.social · 29/08/2025
Adaptive learning is coordinated across behaviour, time and neurobiology (from synapses and dendrites, to astrocytes and the systems level). If you’ve ever wondered how noradrenaline helps shape these multiscale learning processes, you might like this: www.cell.com/trends/cogni...
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Paul Middlebrooks @braininspired.bsky.social · 27/08/2025
youtube.com
BI 219 Xaq Pitkow: Principles and Constraints of Cognition
YouTube video by Brain Inspired
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Nature Reviews Neuroscience @natrevneuro.nature.com · 21/08/2025
Theoretical neuroscience has room to grow — a Comment article by Ann Kennedy @antihebbiann.bsky.social #neuroscience #neuroskyence www.nature.com/articles/s41...
nature.com
Theoretical neuroscience has room to grow - Nature Reviews Neuroscience
The goal of theoretical neuroscience is to uncover principles of neural computation through careful design and interpretation of mathematical models. Here, I examine the use of top-down conceptual and...
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Mac Shine @macshine.bsky.social · 18/08/2025
I need some help from the #neuroskyence Bluesky-verse. Anyone know the source of this ~quote from Walter J. Freeman Jr.: "the secrets of the brain are hidden by two of God’s own firewalls: neurobiology and non-linear dynamics". I read it yrs ago but can't seem to find my way back to the source.
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Guido Meijer @guidomeijer.com · 05/08/2025
🚨Pre-print alert🚨 We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭 How is this possible? Strap in! (1/9) 👇🧵 doi.org/10.1101/2025...
doi.org
Serotonin drives choice-independent reconfiguration of distributed neural activity
Serotonin (5-HT) is a central neuromodulator which is implicated in, amongst other functions, cognitive flexibility. 5-HT is released from the dorsal raphe nucleus (DRN) throughout nearly the entire f...
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Christopher Webb @cwebbonline.com · 30/07/2025
🚨 California and Hawaii under tsunami watch after 8.7M quake in Eastern Russia.
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Takuo Matsuzawa @matsuzawa.bsky.social · 30/07/2025
Tsunami Warning – 7/30, 9:40am The Tsunami Advisory has been upgraded to a Tsunami Warning. Waves of up to 3m are expected. Those near coastal areas, rivers, or lakes should evacuate to higher ground immediately. #tsunami
Tsunami Warning
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Robert Sansom @fossilrob.bsky.social · 27/07/2025
The point is, the monkeys making the loudest noise have the smallest balls. pubmed.ncbi.nlm.nih.gov/26592343/
pubmed.ncbi.nlm.nih.gov
Evolutionary trade-off between vocal tract and testes dimensions in howler monkeys - PubMed
Males often face a trade-off between investments in precopulatory and postcopulatory traits [1], particularly when male-male contest competition determines access to mates [2]. To date, studies of pre...
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Claire Willett @clairewillett.bsky.social · 22/07/2025
Dem leadership should appoint an official Alt Press Secretary to give briefings after every one that Karoline Leavett does and just break them down lie by lie maybe THAT’S the job we give Colbert 😂
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The Transmitter @thetransmitter.bsky.social · 18/07/2025
An exciting collaboration is underway. @thetransmitter.bsky.social is partnering with @neuromatch.bsky.social to serve the computational neuroscience community and help connect neuroscientists across all career stages. www.thetransmitter.org/neuromatch-p... #neuroskyence
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shauna @goldengateblond.bsky.social · 17/07/2025
“the kindest person in the room is often the smartest.” JB Pritzker is a mensch.
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PessoaBrain @pessoabrain.bsky.social · 15/07/2025
Prefrontal axons going to lots of places! doi.org/10.1016/j.ce... #neuroskyence
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Andrew Saxe @saxelab.bsky.social · 11/07/2025
Pairs well with www.nature.com/articles/s41... “Our results indicate that individual V1 neurons do not signal how the actual visual input deviates from the animal’s predictions, as postulated within the predictive coding framework” Thrilling to see a major theory get tested!
nature.com
Cooperative thalamocortical circuit mechanism for sensory prediction errors - Nature
Experiments in mice show that a cortico-thalamic circuit generates prediction-error signals in primary visual cortex that amplify visual input that deviates from animals’ expectations.
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Dan Brierley @drdanbrierley.bsky.social · 21/01/2025
Really proud to start the year by sharing our new review in @endosocjournals.bsky.social on the roles of GLP-1 in eating and obesity treatment, led by superstar postdoc @laurenjonesucl.bsky.social! academic.oup.com/endo/article... 🧪🧠📈 #neuroscience #neuroskyence #GLP-1 #obesity #wegovy #ozempic
academic.oup.com
GLP-1 and the Neurobiology of Eating Control: Recent Advances
Abstract. Obesity is now considered a chronic relapsing progressive disease, associated with increased all-cause mortality that scales with body weight, af
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Kevin Mitchell @wiringthebrain.bsky.social · 09/07/2025
I honestly think we should have a screening system for who gets to have money and influence based on asking "what was Star Wars about?" and "who were the good guys?"
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Nature Reviews Neuroscience @natrevneuro.nature.com · 07/07/2025
Molecular and functional diversity of the autonomic nervous system — a Review by Tongtong Wang, Avedis Tufenkjian, Olujimi A. Ajijola & Yuki Oka #neuroscience #neuroskyence www.nature.com/articles/s41...
nature.com
Molecular and functional diversity of the autonomic nervous system - Nature Reviews Neuroscience
The autonomic nervous system has long been viewed as a simple motor system in brain-to-body signalling. In this review, Wang and colleagues highlight diversity within autonomic neurons and their dynam...
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Tim Kietzmann @timkietzmann.bsky.social · 08/07/2025
Exciting new preprint from the lab: “Adopting a human developmental visual diet yields robust, shape-based AI vision”. A most wonderful case where brain inspiration massively improved AI solutions. Work with @zejinlu.bsky.social @sushrutthorat.bsky.social and Radek Cichy arxiv.org/abs/2507.03168
arxiv.org
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Michelle Greene @mgreenephd.bsky.social · 08/07/2025
🚨 New paper in Journal of Vision! We show that scene affordances—what you can do in a space—shape how we perceive and categorize scenes. This shapes your similarity preferences, predicts your categorization false alarms, and even alters neural representations. 🧵👇 🔗 doi.org/10.1167/jov.... (1/7)
doi.org
Function over form: The temporal evolution of affordance-based scene categorization | JOV | ARVO Journals
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Konrad Kording @kordinglab.bsky.social · 08/07/2025
Attractors are usually not mechanisms - new blog post: open.substack.com/pub/kording/...
open.substack.com
Attractors are usually not mechanisms
The mathematical objects can not be. And the "attractor models" have not been established as mechanisms in mammals
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Valerie Jill Sydnor @valeriejsydnor.bsky.social · 08/07/2025
How does the human brain coordinate hierarchical cortical development? Our work in Nature Neuroscience identifies a role for thalamocortical structural connectivity in the expression of hierarchical periods of cortical plasticity & environmental receptivity in youth 🧵 www.nature.com/articles/s41...
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Ian Phillips @ianbphillips.bsky.social · 28/06/2025
Short new piece on aphantasia just out in TiCS: www.sciencedirect.com/science/arti... Key idea: aphantasia often involves a lack of *visual-object* imagery (explaining subjective reports & objective correlates) but selectively spared *spatial* imagery (explaining preserved task performance).
sciencedirect.com
Spared spatial imagery solves the puzzle of aphantasia
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The Transmitter @thetransmitter.bsky.social · 26/06/2025
ICYMI: “For fMRI to meaningfully contribute to progress in neuroscience, we need to develop research programs that link phenomena across levels,” writes Avram Holmes @avramholmes.bsky.social. www.thetransmitter.org/future-of-fm...
thetransmitter.org
fMRI must break out of its silo
We need to develop research programs that link phenomena across levels, from genes and molecules to cells, circuits, networks and behavior.
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Mac Shine @macshine.bsky.social · 25/06/2025
Another great article from @thetransmitter.bsky.social and Laura Lewis, who has been working painstakingly over the last few years to help ramp up the spatiotemporal resolution of fMRI so that we can really start to dig into whole-brain signals in vivo.
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The Transmitter @thetransmitter.bsky.social · 25/06/2025
ICYMI: Recent technological advances in functional MRI provide a range of new information about brain physiology. Collaboration between engineers and neuroscientists will help maximize these gains, writes Laura Lewis. www.thetransmitter.org/human-neurot...
thetransmitter.org
fMRI can do more than you think
Advances in brain imaging technology provide new and different information about the brain.
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Ben Fulcher @bendfulcher.bsky.social · 25/06/2025
Paper is here: arxiv.org/abs/2506.19800 Code is here: github.com/DynamicsAndN... If you're interested and at #OHBM2025 come watch Rishi present his work in the "Modeling and Analysis - Connectivity" workshop on Saturday in the Great Hall; and check out his poster #1440 (on Friday & Saturday)
arxiv.org
Modeling the influences of non-local connectomic projections on geometrically constrained cortical dynamics
The function and dynamics of the cortex are fundamentally shaped by the specific wiring configurations of its constituent axonal fibers, also known as the connectome. However, many dynamical propertie...
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Ben Fulcher @bendfulcher.bsky.social · 25/06/2025
New preprint! Why are long-range connectomic interactions in the cortex dominant in shaping dynamics in some experiments but apparently negligible in others? We (w/ R Maran, @elimuller.bsky.social) address this question by studying a new hybrid model of cortical dynamics. arxiv.org/abs/2506.19800
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Russ Poldrack @russpoldrack.org · 24/06/2025
The Open Science Room has been an exciting space at the OHBM Meeting for many years, but its future is threatened. Please sign this petition to signal your support for preserving a dedicated space for the OSR at future meetings. ohbm.github.io/osr2025/peti...
ohbm.github.io
OSR Petition
We are launching a petition to request that OHBM preserves the Open Science Room (OSR) as a dedicated space during the annual meeting for the Open Science community. Although Open Science is a well-ac...
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Thomas Nichols @nichols.bsky.social · 24/06/2025
Useful #OHBM2024 deep link - Table listing all posters with stand-by times & categories gmpartners365-my.sharepoint.com/:x:/g/person...
gmpartners365-my.sharepoint.com
Sign in to your account
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Mac Shine @macshine.bsky.social · 23/06/2025
Fantastic article from one of the leaders of the burgeoning field or layer-resolved functional MRI. A pleasure to read!
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The Transmitter @thetransmitter.bsky.social · 23/06/2025
ICYMI: In this essay for our Future of fMRI series, Laurentius Huber @layerfmri.bsky.social explains how new advances in functional MRI could help to connect cells and brain areas at the mesoscopic scale. #neuroskyence #OHBM2025 www.thetransmitter.org/future-of-fm...
thetransmitter.org
Imaging cortical layers to understand brain as network organ
This spatial scale, bridging cells and brain areas, has been overlooked in human brain research. But advances in fMRI technology are changing that.
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Giulia Baracchini @giuliaabaracc.bsky.social · 20/06/2025
The diversity of methods we use to probe the brain (epistemologies) naturally leads to clashes in our theories of how the brain works (ontologies). So how do we reconcile this divide and grow into a more unified neuroscience? Here is our take: apertureneuro.org/article/1388...
apertureneuro.org
Bridging the epistemological divide in neuroscience to improve ontological clarity | Published in Aperture Neuro
By Giulia Baracchini, Eli Muller & 1 more. This perspective highlights the epistemological divide that arises from the wide variety of different experimental approaches... which in turn lead to ontolo...
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Aperture Neuro @apertureohbm.bsky.social · 20/06/2025
🧠 The State of the Brain Special Issue features insights from last year’s keynotes, award winners & committee leaders. 🔗 Explore major findings & themes from 2024: apertureneuro.org/issue/12560 @arokem.org @alexfornito.bsky.social @macshine.bsky.social @vcalhoun.bsky.social @misicbata.bsky.social
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Christopher Whyte @christopherjwhyte.bsky.social · 02/06/2025
New preprint modelling suppression depth in binocular rivalry and continuous flash suppression with Hugh Wilson, @macshine.bsky.social, & David Alais
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Russ Poldrack @russpoldrack.org · 30/05/2025
COS Statement on “Restoring Gold Standard Science” Executive Order www.cos.io/about/news/c...
cos.io
COS Statement on “Restoring Gold Standard Science” Executive Order
The Executive Order issued on May 23, 2025, Restoring Gold Standard Science, references several open science practices championed by COS and the open science and metascience communities more generally...
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PessoaBrain @pessoabrain.bsky.social · 28/05/2025
𝗠𝗮𝘆𝗯𝗲 𝗰𝗼𝗻𝘀𝗰𝗶𝗼𝘂𝘀𝗻𝗲𝘀𝘀 𝗶𝘀 𝗮 𝗯𝗶𝗼𝗹𝗼𝗴𝗶𝗰𝗮𝗹 𝗽𝗵𝗲𝗻𝗼𝗺𝗲𝗻𝗼𝗻 𝗮𝗳𝘁𝗲𝗿 𝗮𝗹𝗹 This target paper by Anil Seth should lead to good discussion. www.cambridge.org/core/journal...
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Lucina Uddin @lucinauddin.bsky.social · 28/05/2025
When I first started working with resting state fMRI as a postdoc, there was a lot of skepticism about what we could learn from it. 20 years later, it's hard to imagine where the field of neuroscience would be without it. Here's a summary 🧠 www.nature.com/articles/s41...
nature.com
The history and future of resting-state functional magnetic resonance imaging - Nature
This Review provides an overview of the history of resting-state functional MRI research, which has helped to reveal the spatiotemporal organization of the brain, and discusses how it can contribute f...
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Mac Shine @macshine.bsky.social · 26/05/2025
Hard agree. Great article on a timely issue by @neuralreckoning.bsky.social for @thetransmitter.bsky.social
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