I’ve spent a lot of time thinking about the plausibility of standardized effect sizes in the last year. From a trustworthiness assessment perspective, (standardized) effect sizes have a great combinat...

One small study in Iran swayed meta-analyses in favour of antidepressant use in children, researchers say.

Objective To explain discrepant findings for fluoxetine's efficacy in three influential network meta-analyses (NMAs) of treatments for pediatric depression, which led to conflicting clinical recomme...

One small study in Iran swayed meta-analyses in favour of antidepressant use in children, researchers say.

Objective To explain discrepant findings for fluoxetine's efficacy in three influential network meta-analyses (NMAs) of treatments for pediatric depression, which led to conflicting clinical recomme.....

This cross-sectional study evaluates which open science practices have been adopted by leading general medical journals and whether automated tools can assess article-level adherence.

To describe and characterize three partly coexisting evidentiary configurations in drug regulation and health technology assessment (HTA), and to examine the inferential consequences of the progressiv...

There are comments on PubPeer for publication: Efficacy and safety evaluation of intravenous esketamine in alleviating perioperative depressive symptoms in Parkinson’s disease: a randomized controlled...

Objective Depressive symptoms frequently afflict individuals with Parkinson’s disease (PD). The current study was consequently conducted to determine the efficacy of low-dose intravenous esketamine in...

In cluster-randomised trials (CRTs), different estimands can be targeted, such as the individual- or cluster-average effect. These two estimands can differ in magnitude when outcomes or treatment effe...

Objective In 2021, a large-scale survey highlighted that in a subset of biomedical journals, a few authors –often serving on the editorial board– published disproportionately and experienced shorter a...

Fluoxetine’s efficacy estimates in pediatric depression trials have declined to the range of placebo equivalence. We investigated whether changes in t…

We are preparing substantial changes to OSF that will reduce its functionality, focus OSF on its unique strengths, and move toward an integrated model with complementary services. As part of that shif...

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Understanding how age affects antidepressant response in patients with major depressive disorder has been complicated by small and heterogeneous studi…

The GRIOS open call for evidence synthesis on Open Science closed on 20 July 2026. We are grateful to all who submitted a proposal — the response has exceeded our expectations. Over 70 proposals we...

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Critics say TriNetX’s easy analyses of electronic medical records fuel quick-and-dirty publications from inexperienced authors

Conflicts of interest and political and emotional pressures are key challenges Regulatory agencies face growing pressure to approve drugs despite major safety and efficacy concerns. Over decades, th...