iiinova — where your digital self keeps evolving

Luke Lavis @rhodamine110.bsky.social · 24/03/2026

The best two years you can spend before graduate school! Get the hands of a 4th-year grad student contributing to Open Science: bit.ly/47mU5xx Or join an interdisciplinary AI/biology team (don't worry, the AI still needs you to do the actual experiments): bit.ly/4taqzni Both at Janelia!

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Research Technician - Tool Translation Team

Primary Work Address: 19700 Helix Drive, Ashburn, VA, 20147 Current HHMI Employees, click here to apply via your Workday account. Summary: We are seeking a chemist to join the Tool Translation Team, "...

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Keri Backus @keribackus.bsky.social · 06/02/2026

Excited to share our new paper and lipid- and protein-directed photocatalytic labeling method (POCA) just out in @natchembio.nature.com. tinyurl.com/2kcxuvvv. Big congrats to first author Andrew Becker and the whole team for launching our lab into the wild world of singlet oxygen interactomics.

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adamezracohen.bsky.social @adamezracohen.bsky.social · 04/01/2026

Thanks, as always, to @rhodamine110.bsky.social for hooking us up with buckets of JaneliaFluor-HaloTag ligand dyes.

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adamezracohen.bsky.social @adamezracohen.bsky.social · 04/01/2026

What is the computational role of dendritic excitations? Byung Hun Lee and team mapped voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons in mice navigating in virtual reality. www.biorxiv.org/content/10.6...

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Bryan Dickinson @chembiobryan.bsky.social · 11/11/2025

Registration for THE chemical biology conference of 2026 is now open! EMBO ChemBio 2026 in Heidelberg DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social www.embl.org/about/info/c...

embl.org

Chemical biology 2026

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Luke Lavis @rhodamine110.bsky.social · 11/11/2025

Cool paper using a new JF derivative to map synaptic proteins. And AI didn't like the generality of our general synthetic methods section (that we've used for years), so we expanded them from 2 succinct paragraphs to 1.5 gloriously unreadable pages. Better than Ambien. www.nature.com/articles/s41...

nature.com

Single-cell synaptome mapping of endogenous protein subpopulations in mammalian brain - Nature Communications

Synapses are diverse within a single neuron. Here, the authors present a method for single-cell synaptome imaging of endogenous protein subpopulations in the mouse brain, enabling spatial mapping of s...

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Luke Lavis @rhodamine110.bsky.social · 30/10/2025

Outlook is autocorrecting "on:off ratio" to "on😯ff ratio" and I love it so much.

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Sam Connell @samuelconnell.3i.social · 28/10/2025

Very cool collaborative work between multiple groups across three institutions. Shoutout to @rhodamine110.bsky.social and his crew along with longtime @the.3i.social community @so-lets-kilab70.bsky.social for deploying 3i's #latticelightsheet for some particularly elegant chromatin microscopy. 🔥🔬🧠🧬🥽

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Luke Lavis @rhodamine110.bsky.social · 28/10/2025

Just upgraded to a Claude Enterprise account (thanks HHMI) and was playing with the Molecule studio artifact. Here is rhodamine 110, my BlueSky username. Looks like our jobs are safe for now!

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Janelia Research Campus @hhmijanelia.bsky.social · 19/09/2025

📢 Applications are open for the 4th installment of our ChemTools conference. We'll explore: 🧪 Platforms & tools for analyzing cell/tissue networks ⚡ Methods to perturb biological networks 🔍 Applications that yield new insights 🛏️ Lodging + meals covered ➡️ Apply by Dec 5: janelia.news/CHM26

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Luke Lavis @rhodamine110.bsky.social · 19/08/2025

PSA: If you are a #ChemDraw user on the Mac, they changed the font for the ACS Document 1996 style in the recent past; Helvetica to Arial. Watch out for vestigial Helvetica characters in figures, which some journal submission platforms *really* don't like.

media.tenor.com

a rainbow and a star with the words " make you know " on it

ALT: a rainbow and a star with the words " make you know " on it

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FASEB @faseborg.bsky.social · 18/04/2025

The sophomore outing for this revelatory conference is here! Join us for #OPTSRC for the latest in optical probes, which are crucial for biological imaging techniques. You'll meet organizers like @rhodamine110.bsky.social and more. View the agenda and save your space: buff.ly/LIRRF15

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Luke Lavis @rhodamine110.bsky.social · 11/04/2025

We're looking for 1-2 enthusiastic early career chemists to join our Open Chemistry team at @hhmijanelia.bsky.social. Come help us create amazing dyes and share them with the world. Please share with the best recent/soon-to-be B.S. chemists you know! bit.ly/42w8C6N

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Research Technician - Open Chemistry

Primary Work Address: 19700 Helix Drive, Ashburn, VA, 20147 Current HHMI Employees, click here to apply via your Workday account. Summary: Open Chemistry is a collaborative research group whose missio...

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Sam Connell @samuelconnell.3i.social · 03/04/2025

Thanks Luke! Grateful for your good work kind sir. Thirty years ago, I remember crowding around the lightbox in awe with my Pharmingen R&D colleagues at the glowing BioColors vectors we had grown up after licensing from Roger Tsien's Lab down the street at UCSD where I was about to graduate. 🔬🧪🥽🔥🌈

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a picture of luke skywalker with the words luke !!! above him

ALT: a picture of luke skywalker with the words luke !!! above him

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Luke Lavis @rhodamine110.bsky.social · 03/04/2025

I’ve been a dye chemist for a quarter century! 25 years ago today I walked into this funky little company in Eugene, OR called Molecular Probes. My first task was making Alexa Fluor 633 and I never looked back. I am grateful for all my teachers and mentors along the way.

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Janelia Research Campus @hhmijanelia.bsky.social · 31/03/2025

🥼 Janelia researchers led by @boazmohar.bsky.social @nspruston.bsky.social @rhodamine110.bsky.social & @svoboda314.bsky.social @alleninstitute.bsky.social have developed a new imaging tool that maps brain-wide changes in neuronal connections. 🧠 🔗 www.janelia.org/news/new-ima...

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Luke Lavis @rhodamine110.bsky.social · 30/03/2025

A little nugget of whimsy: Apple Music has these “lyrics” for the Star Wars main theme (from ESB).

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Luke Lavis @rhodamine110.bsky.social · 28/03/2025

You know you're getting old when your Organic Chemistry Lab TA training partner from the first week of grad school is now an editor at @acs.org (does this mean I have to click 'Accept' @pomerantz.bsky.social?)

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Luke Lavis @rhodamine110.bsky.social · 28/03/2025

How it started: About eight years ago Bob Tjian ("Tij") and I sat in the back of cab in San Francisco and discussed the crazy idea of using live-cell single-molecule tracking for high-throughput drug screening. How it's going:

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Luke Lavis @rhodamine110.bsky.social · 01/03/2025

Hey #chemsky and beyond, with all that is going on, I am curious what expensive, high margin molecules we could provide to the community for free. What things do you use all the time, cost way too much, and would make a difference? Alexa Fluor 488 NHS? Other dyes? Other molecule?

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Luke Lavis @rhodamine110.bsky.social · 13/02/2025

Had a blast writing this piece celebrating the latest paper in @pubs.acs.org from @ellensletten.bsky.social and Ellen’s general awesomeness. My 11-year old daughter was my coauthor! (try to find all the Easter Eggs) pubs.acs.org/doi/10.1021/...

pubs.acs.org

Stars by the Pocketful

SWIR dyes─The Eras Tour. This love story between chemistry and biology shines.

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Luke Lavis @rhodamine110.bsky.social · 30/12/2024

I love that sodium borate resulted in the protection of some of the most beautiful coastline on the planet. en.wikipedia.org/wiki/Samuel_...

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Luke Lavis @rhodamine110.bsky.social · 30/12/2024

Discipline-appropriate cocktail.

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Luke Lavis @rhodamine110.bsky.social · 18/12/2024

That moment when you show up at a conference and some Max Planck Director stole your outfit. #twinning #sciencefashion #whoworeitbest

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Luke Lavis @rhodamine110.bsky.social · 13/12/2024

Epic food day in Singapore. Roti prata for breakfast, umm didn't need lunch, frog porridge for dinner, and the king of fruits for dessert. On to my next stop tomorrow but thankful for the visit and hospitality in this lovely country.

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Luke Lavis @rhodamine110.bsky.social · 11/12/2024

Excited for the second day of our symposium at the Singapore International Chemistry Conference. Such a beautiful city.

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Luke Lavis @rhodamine110.bsky.social · 02/12/2024

PSA: Just updated Adobe Illustrator to 29.1 and noticed a quirk—deleting text and then retyping causes a switch to Myriad Pro. To fix it, head to Preferences > Type and disable "Missing Glyph Protection". Hope this saves fellow figure smiths some time and frustration!

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Luke Lavis @rhodamine110.bsky.social · 28/11/2024

My first post-twitter post highlights a fantastic paper by Tim Mitchison and Pamela Silver. Tim has always been an inspiration to me, and it's rewarding to see him working with the JF dyes, molecules we developed, and collaborating with Eikon, a company we co-founded. www.biorxiv.org/content/10.1...

biorxiv.org

Comparative evaluation of cell-based assay technologies for scoring drug-induced condensation of SARS-CoV-2 nucleocapsid protein

Protein-nucleic acid phase separation has been implicated in many diseases such as viral infections, neurodegeneration, and cancer. There is great interest in identifying condensate modulators (CMODs)...

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