A regulatory sequence code for neuronal microexons reveals genetic variants predicted to alter their splicing in individuals with autism.

Organoids are transforming biomedical science, but their promise hinges on shifting from episodic ethics review to sustained, integrated stewardship. We argue that such stewardship must evolve alongsi...

Low-affinity transcription factor binding sites are functionally important but difficult to map and mechanistically poorly understood. In this issue of Cell Genomics, Weilert et al. leverage sequence-...

Why do mammalian species develop at different speeds? Nakanoh, Stamataki, et al. show that mouse neural progenitors have faster protein synthesis and proteasome-mediated degradation than human. Manipu...

A combination of drugs restores stem-cell function in mouse models of the blood disorder.

This study introduces iChIP2, a low-input chromatin immunoprecipitation followed by sequencing method that profiles histone post-translational modifications (hPTMs) simultaneously across diverse eukar...

In Drosophila, cell fate switching in adult intestinal stem cells is determined through an epigenetic mechanism in which these cells count divisions, switching from producing enterocytes to producing ...

Schindler et al. report that RNA-binding proteins undergo widespread S-nitrosylation at evolutionarily conserved sites. S-nitrosylation of the master splicing regulator PTBP1 alters RNA-binding properties to reprogram the transcriptome and proteome. Nitric oxide thereby coordinates gene and protein regulation in cellular physiology and disease.

Biochemical, structural and cell biological analyses reveal that UAP56 (DDX39B) assembles with a TREX-2–like module that redirects non-functional polyadenylated RNAs from export to degradati...

Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of the bacterial large ribosomal subunit.

Rare diseases affect small, dispersed populations and are often studied through multisite designs where equity-relevant demographic data are essential for inclusive recruitment and accurate interpreta...

For decades, the diagnosis of rare genetic disorders has relied on a phenotype-driven approach, often resulting in a prolonged “diagnostic odyssey.” T…

In vivo single-cell ribosome profiling reveals cell-type-specific translational landscapes across the epidermis and uncovers selective reprogramming of AP-1 subunit translation in aged stem cells, linking translational deregulation to stem cell aging.

Scientists caution that more research is needed, but nearly all of the patients who responded to the personalized vaccine are still alive six years later.

Spatial maps of gene expression in whole human embryos across several weeks of early development offer insights into the molecular programs that drive organogenesis.

The KATMAP model, developed by researchers in the Department of Biology, can predict alternative cell splicing, which allows cells to create endless diversity from the same sets of genetic blueprints.

Schindler et al. report that RNA-binding proteins undergo widespread S-nitrosylation at evolutionarily conserved sites. S-nitrosylation of the master splicing regulator PTBP1 alters RNA-binding properties to reprogram the transcriptome and proteome. Nitric oxide thereby coordinates gene and protein regulation in cellular physiology and disease.

Nature Reviews Cancer, Published online: 14 May 2026; doi:10.1038/s41568-026-00933-zAerobic exercise influences physiology and generally reduces cancer risk, yet the mechanisms connecting these effects remain incompletely understood. In this Perspective, Zhuang and colleagues outline a model in which exercise-induced physiological adaptation regulates adult stem cell behaviour in ways that limit transformation and tumour initiation.

This study identifies distinct transposable element subfamilies as genetic determinants of stemness properties in normal and leukemic stem populations with clinical implications for patients with acut...

Tian et al. identify LENG8 as a conserved RNA quality-control factor that prevents nuclear export of misprocessed mRNAs and noncoding RNAs. This study provides fundamental insight into how the surveillance machinery monitors RNA processing status to determine nuclear retention, degradation, or export.

Fragments of aberrant cytoplasmic mRNA pair with nuclear RNAs to augment transcription

Execution of mRNA cleavage in nonsense-mediated decay remained elusive. The authors show that SMG5 complements SMG6 to form a highly active, composite endonuclease with expanded catalytic center that ...

March of Dimes names Dr. Leonard Zon winner of the 2026 Richard B. Johnston Jr., MD Prize for breakthroughs in developmental biology and treatments for blood disorders.

Fragments of aberrant cytoplasmic mRNA pair with nuclear RNAs to augment transcription

Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and s...

The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

Transcriptional adaptation (TA) is a genetic robustness mechanism through which mutant messenger RNA (mRNA) decay induces sequence-dependent up-regulation of so-called adapting genes. How cytoplasmica...

RNA-binding proteins (RBPs) constitute a diverse class of proteins essential for every stage of the gene expression process. Many RBPs are also linked to human diseases and pathologies. Understandi...

Kretov et al. introduce RBPscan, an RNA-editing-based platform that measures how RNA-binding proteins engage their targets in living cells. This approach quantifies the binding strength of protein-RNA...