Triple-negative breast cancer (TNBC) is an aggressive, heterogeneous subtype with limited treatment options. Here, transcriptional network inference integrated with chromatin accessibility across prim...

Triple-negative breast cancer (TNBC) is an aggressive, heterogeneous subtype with limited treatment options. Here, transcriptional network inference integrated with chromatin accessibility across prim...

This study identifies distinct transposable element subfamilies as genetic determinants of stemness properties in normal and leukemic stem populations with clinical implications for patients with acut...

By mapping chromatin accessibility over transposable elements (TEs) across normal hematopoietic cells and the various cell types of primary acute myeloid leukemia (AML), we identified TE subfamilies w...

Professeur honoraire au Collège de France, professeur émérite à la faculté de médecine de l’université de Strasbourg, ce natif de Mulhouse, âgé de ...

This study identifies distinct transposable element subfamilies as genetic determinants of stemness properties in normal and leukemic stem populations with clinical implications for patients with acut...

Zeng et al. analyzed cfDNA methylation and fragmentomic data from 1,294 patient plasma samples across 14 major cancer types to present a comprehensive landscape of pancancer and cancer-specific cell-f...

Zeng et al. analyzed cfDNA methylation and fragmentomic data from 1,294 patient plasma samples across 14 major cancer types to present a comprehensive landscape of pancancer and cancer-specific cell-f...

Zeng et al. analyzed cfDNA methylation and fragmentomic data from 1,294 patient plasma samples across 14 major cancer types to present a comprehensive landscape of pancancer and cancer-specific cell-f...

He and colleagues develop a METTL3-based RNA base-editing screening strategy to identify functional N6-methyladenosine (m6A) sites that are important for prostate cancer cells and validate the role of...

He and colleagues develop a METTL3-based RNA base-editing screening strategy to identify functional N6-methyladenosine (m6A) sites that are important for prostate cancer cells and validate the role of...

The impact of tumour heterogeneity on metastatic potential in prostate cancer remains poorly understood. Here, the analysis of single nuclei RNA sequencing and whole-genome sequencing from samples fro...

Understanding tumor heterogeneity and its impact on prostate cancer progression remains elusive. Here, single nucleus snATAC and snRNA sequencing of a multi-loci sampled cohort of advanced prostate ca...

Understanding tumor heterogeneity and its impact on prostate cancer progression remains elusive. Here, single nucleus snATAC and snRNA sequencing of a multi-loci sampled cohort of advanced prostate ca...

The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitatin...

Cancer is fundamentally a complex, multifactorial disease, and research fields have grown from viewing cancer through different mechanistic lenses. 1.    Cancer as an immune-related disease. This vi...

In cross-sectional and longitudinal analyses of 86,149 participants across 27 European countries, Amoruso, Hernandez and colleagues identify multilingualism as a protective factor against accelerated aging, using biobehavioral age gaps.

YouTube video by theCrux

Discovery-based and/or translational research using model organism genetics and/or stem cell and organoid platforms to study paediatric cancer.

imageimagePaternal environmental exposures have been linked with modulation of phenotype and disease risk in offspring via largely unclear mechanisms. This study employs in vitro fertilization and sin...

The Max Perutz Labs - one of Europe’s leading institutes for basic research in the life sciences - invite applications for a Full Professorship in Molecular Mechanisms of Disease. We are seeking outst...

Epigenome editing programs gene silencing without inducing DNA breaks but challenges in delivery into human cells limit its broader use. Here, the authors present the RENDER platform, which uses virus...

Proteins are the cornerstone of life. However, the proteomic blueprint of aging across human tissues remains uncharted. Here, we present a comprehensi…

Competition between transcription factors and mismatch repair machinery drives localized hypermutation at regulatory elements, with implications for cancer and genome evolution.

Provide leadership and mentorship to members of the Developmental, Stem Cell & Cancer and influence the scientific direction of the Research Institute

YouTube video by University of New England

YouTube video by University of New England

The 2025 Gordon Research Conference on Hormone-Dependent Cancers will be held in Newry, Maine. Apply today to reserve your spot.

Changes in gene expression regulated by ligand-dependent transcription factors such as estrogen receptor-α (ERα) involves the recruitment of coactivators including p300 that acetylates histone H3 at l...