Most lung cancers are tobacco related, with genetic factors influencing smoking behavior identified through genome-wide association studies. However, inherited risk in familial and non-smoking-related...

Effectively treating NRAS-mutant cancers may require a combined pan-RAS and HRAS-specific strategy.

#LRUA26: Empower your research with long-read sequencing technologies and connect with experts, peers, and industry leaders in Uppsala this November.

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Nature Reviews Genetics, Published online: 03 August 2026; doi:10.1038/s41576-026-00993-9Ageing has often been conceptualized as a gradual, linear decline, yet growing evidence suggests it unfolds through dynamic, stage-specific transitions. In this Perspective, the authors examine such evidence across molecular and physiological systems and discuss analytical frameworks to identify non-linear transitions.

Nature Reviews Cancer - Twenty-five years after the launch of Nature Reviews Cancer, the experiences of women in cancer research have changed in important ways, with gains in visibility,...

Mistry et al. propose that Dnmt3a-mutant haematopoietic cells induce mesenchymal stromal cell senescence. Removal of senescent non-haematopoietic cells reduces Dnmt3a-mutant haematopoiesis.

The RNA-binding protein ZFP36L2 mediates stress-adaptive plasticity in intestinal regeneration and colorectal cancer metastasis.

Nature - The international collaboration of the Human Cancer Models Initiative presents a comprehensive resource of next-generation cancer models from 2,780 donors with 25 cancer types and...

Hu et al. develop POND-seq, a nanocage-based strategy that exports RNA information from living cells without disruption. This approach enables repeated sampling of the same cell population to track tr...

RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource.

Leukemia - Cancer is an RNA disease: DNA is not destiny, RNA determines leukemia fate

Experimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving mutations in shaping the earliest stage...

Parents want accountability after study went disastrously wrong, Science and Retraction Watch investigation reveals

Adaptive immunity relies on T-cell receptor (TCR) recognition of peptides presented by the major histocompatibility complex (pMHC). Accurate prediction of TCR:pMHC binding pairs from sequence data rem...

Jagannatha et al. use a large-scale tethering screen to systematically identify RNA-binding proteins (RBPs) that regulate alternative polyadenylation, build a sequence-based model that predicts poly(A) site-selection activators, and uncover direct links between GRB2, RNPS1, and the cleavage and polyadenylation machinery.

Farhangmehr et al. investigate functions of highly conserved intronic sequences in cell fitness using a CRISPR-based deletion screen. Deletions in FNBP4 intron lead to changes in p53 pathway genes. De...

Palikyras and colleagues investigate chromatin reorganization upon senescence induction, reporting that components of nuclear speckles coordinate chromatin rewiring and a senescence-associated splicin...

Most genetic variants associated with complex traits are hypothesized to regulate gene expression. To understand the genetics underlying gene expression variability, we characterized 14,324 RNA-sequen...

Elimination of all spliceosomal introns reveals a spliceosome-independent eukaryote.

Different RNA modifications elicit different translation elongation rates for in vitro transcribed mRNAs that result in disparate translation outputs and fidelity, as shown here for N4-acetylcytidine ...

A Landmark Study Showing the Way Forward

Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis of fully active proteins.

Surveying recent progress in neoantigen cancer vaccine development, this Review highlights areas where further technological advances and optimized trial design could enhance clinical impact.

Our previous work has uncovered key mechanisms linking systemic changes to tumor initiation, single cell signatures of models of breast normal and cancer development and identified epigenetic and...

Schindler et al. report that RNA-binding proteins undergo widespread S-nitrosylation at evolutionarily conserved sites. S-nitrosylation of the master splicing regulator PTBP1 alters RNA-binding properties to reprogram the transcriptome and proteome. Nitric oxide thereby coordinates gene and protein regulation in cellular physiology and disease.

Nature Reviews Cancer, Published online: 14 May 2026; doi:10.1038/s41568-026-00933-zAerobic exercise influences physiology and generally reduces cancer risk, yet the mechanisms connecting these effects remain incompletely understood. In this Perspective, Zhuang and colleagues outline a model in which exercise-induced physiological adaptation regulates adult stem cell behaviour in ways that limit transformation and tumour initiation.

Nature Reviews Molecular Cell Biology, Published online: 11 May 2026; doi:10.1038/s41580-026-00974-0Organoids are powerful tools for studying human development and disease mechanisms in vitro. This Review discusses their limitations and recent advances that increase their complexity to better mimic natural tissues, and the potential impact on therapeutic applications.

Immune-remodeling mRNAs delivered in lipid nanoparticles boost antitumor immunity.