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Manuel Irimia

@mirimiam.bsky.social
1.4K followers 663 following 77 posts

ICREA Evolutionary Biologist working on transcriptomics of development and evolution at @upf.edu and @crg.eu. Coordinator of the @evomg-bcn.bsky.social Joint Program. Lab website: transdevolab.com

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Reposted by Manuel Irimia
Manuel Irimia @mirimiam.bsky.social · 03/09/2026
🚨🚨🚨 As part of the MSCA-DN DECODES, we're looking for a PhD student to study splicing programs in beta cells and diabetes at @melisupf.bsky.social @crg.eu Join 14 other PhD students across Europe to decipher the splicing code in human disease. More info below 👇 www.findaphd.com/phds/project...
findaphd.com
DECODES at University of Santiago de Compostela on FindAPhD.com
PhD Project - DECODES at University of Santiago de Compostela, listed on FindAPhD.com
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Manuel Irimia @mirimiam.bsky.social · 03/09/2026
🚨🚨🚨 As part of the MSCA-DN DECODES, we're looking for a PhD student to study splicing programs in beta cells and diabetes at @melisupf.bsky.social @crg.eu Join 14 other PhD students across Europe to decipher the splicing code in human disease. More info below 👇 www.findaphd.com/phds/project...
findaphd.com
DECODES at University of Santiago de Compostela on FindAPhD.com
PhD Project - DECODES at University of Santiago de Compostela, listed on FindAPhD.com
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Al Jord Lab @aljordlab.bsky.social · 21/08/2026
Transcription stops. RNA splicing takes over 🧬 ✨ Our new preprint uncovers the post-transcriptional RNA splicing landscape powering mammalian oocyte development. Read it here 👇 www.biorxiv.org/content/10.6...
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Isabel Almudi @isabelalmudi.bsky.social · 07/08/2026
What happens when evolution adds an extra pair of eyes? Male mayflies evolve an extra pair of dorsal compound eyes, the Turbanate eyes, thought to help males detect females during mating swarms. we have investigate how this remarkable evolutionary novelty develops. www.biorxiv.org/content/10.6...
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Alex de Mendoza @alexdemendoza.bsky.social · 03/08/2026
Sailing in @biorxivpreprint.bsky.social ready for summer, our study on the iconic Portuguese man o' war 🪼 is out: www.biorxiv.org/content/10.6.... We use (epi)genomics to understand a critter that fascinates me since childhood. Massive team effort with @obog.bsky.social, Cummins and Neely groups. 🧵
the indo-pacific bluebottle (Physalia utriculus)
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Max Stammnitz @maxstammnitz.bsky.social · 22/07/2026
Wow! A fourth class of transmissible cancers. CONTAGIOUS FISH MELANOMA, discovered in Lake Memphremagog (Vermont / Quebec) 🎣 🧬 😷 www.nature.com/articles/s41... @uvmvermont.bsky.social
nature.com
Brown bullhead catfish melanoma represents a novel transmissible cancer - Nature
Whole-genome sequencing analysis of tumour and matched non-tumour host tissues of the brown bullhead catfish reveals a type of naturally occurring transmissible cancer.
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Ulrich Braunschweig @braunschweig.bsky.social · 20/07/2026
What happens if you delete large intronic regions? In human tissue culture cells, we found many deletions that decrease growth and some that increase it. In most cases, deletion affected expression or splicing of the gene. www.cell.com/cell-reports... 1/3
cell.com
A genome-wide functional analysis of conserved intronic regions reveals essential roles for speckle-associated retained introns
Farhangmehr et al. investigate functions of highly conserved intronic sequences in cell fitness using a CRISPR-based deletion screen. Deletions in FNBP4 intron lead to changes in p53 pathway genes. De...
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Barbara Pernaute @bpernaute.bsky.social · 24/06/2026
🚨 Early Bird registration and abstract submission deadline for #SEBD2026 extended!! 📅 Early registration and abstract submission deadline: 10th July 📅 Scholarship application deadline: 29th June www.sebd2026.com #SEBD #DevBio @sebioldev.bsky.social 👇👇👇
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James Briscoe @jamesbriscoe.bsky.social · 02/07/2026
Paying peer reviewers Interview with @danielgorelick.bsky.social about @biologyopen.bsky.social Fast & Fair trial in which peer reviewers were paid £220/review Spoiler: it works - fast, high quality reviews www.nature.com/articles/d41...
nature.com
Why paying peer reviewers works, according to a journal’s editor-in-chief
A biology journal that paid peer reviewers found that the approach cut the time to a first editorial decision by 85% and maintained high-quality reviews.
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tahneema.bsky.social @tahneema.bsky.social · 28/06/2026
Very excited to finally share my PhD! 🎉 Our paper, “Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish,” is now published in Science Advances. Many thanks to all of my co-authors, and especially to @mirimiam.bsky.social! 📄 www.science.org/doi/10.1126/...
science.org
Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish
Loss of the conserved splicing factor for neuronal microexons disrupts neuromodulatory signaling and drives hyperarousal.
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Parc de Recerca Biomèdica de Barcelona @prbb.org · 19/06/2026
🦟 Why don’t viruses kill the mosquitoes that transmit them? 🔬 A study reveals how these insects coexist with viruses such as dengue and Zika, and what this can teach us about their spread and control. Learn more:  tuit.cat/uu8EJ @melisupf.bsky.social
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The Company of Biologists @biologists.bsky.social · 18/06/2026
Thank you to organisers to James Hombría and Antónia Monteiro @monteirolab.bsky.social and everyone who joined us at this week's Workshop on 'Novelty, Co-option and Divergence During Gene Network Evolution' biologists.com/workshops #BiologistsWorkshops
Group photo of Workshop attendees
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Toni Gabaldón @tonigabaldon.bsky.social · 10/06/2026
Our paper "Gene ancestries reveal diverse microbial associations during eukaryogenesis.” is finally out in Nature. Eukaryogenesis was likely a gradual process shaped by multiple microbial partners and virus-mediated gene transfer, rather than a single binary symbiosis. doi.org/10.1038/s415...
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preLights @prelights.bsky.social · 02/06/2026
61 species, 13 phyla, one simple geometric rule that appears to set when every embryo starts speaking through its own genome. 🧬 Panagiotis Giannios highlights a recent #preprint from @mirimiam.bsky.social & collaborators. #EvolutionaryBiology #preLight: prelights.biologists.com/highlights/e...
prelights.biologists.com
Evolutionary landscapes of zygotic genome activation across animals - preLights
61 species, 13 phyla, one simple geometric rule that appears to set when every embryo starts speaking through its own genome.
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Zebrafish Rock! @zebrafishrock.bsky.social · 02/06/2026
Fin-catching prelight on @mirimiam.bsky.social et al.'s preprint on the animal zoo 🐟🧬
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EvoMG Program @evomg-bcn.bsky.social · 01/06/2026
We had a great seminar by Duncan Odom @odomlab.bsky.social today about mutagenesis and cancer evolution!
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Centre de Regulació Genòmica (CRG) @crg.eu · 31/05/2026
Huge congrats to the CRG's Mafalda Dias for being one of eight finalists for the 2026 Premio Vanguardia de la Ciencia, one of Spain's most visible science prizes. Voting is open now and closes on Sunday 28 June at 23:59 (peninsular time).
lavanguardia.com
La IA mejora el estudio de las enfermedades raras
Vota a las finalistas del premio Vanguardia de la Ciencia
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Gioia Quarantani @gioia-quarantani.bsky.social · 26/05/2026
1\ Excited to finally share some of my PhD work: OpenSplice! We measured how >590,000 mutations affect exon inclusion across 600 human exons, creating a resource to study splicing regulation, benchmark variant effect predictors, and support variant interpretation.
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Alex de Mendoza @alexdemendoza.bsky.social · 26/05/2026
New preprint! In an fun collaboration with @imaeso.bsky.social and @mirimiam.bsky.social led by Manu F-M, we set to explore the potential adaptation of transposable elements 👾 to host adenine DNA methylation by recruiting prokaryotic DAM methyltransferases: www.biorxiv.org/content/10.6.... 1/6
biorxiv.org
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Alejandro Burga @arburga.bsky.social · 18/05/2026
🧬 New research from the Burga lab! We took a closer look at a rogue selfish protein and caught evolution in the act of turning something old into something radically new 💡 (a.k.a. neofunctionalization) @imbavienna.bsky.social www.biorxiv.org/content/10.6... Curious? Here’s a breakdown:
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Schubeler Lab @schubelerlab.bsky.social · 07/05/2026
Excited to share our new study on CpG islands (CGIs) regulation by transcription factors (TFs)! CGIs drive most transcription initiation with unclear regulation. We find that chromatin-opening TFs are key players—following a surprisingly simple rule. 🧵 www.biorxiv.org/content/10.6... 1/9
biorxiv.org
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Isabel Almudi @isabelalmudi.bsky.social · 29/04/2026
Exhausted but extremely happy for the two past days of very exciting Science! The EvoDevOmics Spanish Network gathered together in BCN to discuss about evodevo & omics, lots of great talks, discussions and future collaborations. 🤩 #evodevo
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imaeso.bsky.social @imaeso.bsky.social · 29/04/2026
@fany-real.bsky.social, @multicellgenome.bsky.social, @obog.bsky.social, @arnausebe.bsky.social, @bpernaute.bsky.social, @malmuedocas.bsky.social & Nuria Flames
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imaeso.bsky.social @imaeso.bsky.social · 29/04/2026
Amazing couple of days enjoying & discussing science in the best possible company during the Barcelona meeting of the 'EvoDevOmics Network', funded by @ageinves.bsky.social. Really happy to see how the EvoDevo community in Spain is thriving & fostering a fantastic new generation of PhDs & Postdocs.
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Johanna Joyce @johannajoyce.bsky.social · 22/04/2026
What should Europe do when demand for #ERC funding keeps rising? Restrict access or invest in excellence? Please read our open letter calling for reconsideration of the ERC 2027 resubmission restrictions & for constructive alternatives that preserve openness Consider to share & sign - see below 🧪
linkedin.com
#erc | Johanna Joyce
What should Europe do when demand for its most successful frontier research programme keeps rising? Restrict access, or invest in the excellence it has created? A new open letter, spearheaded by Sara...
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Ali Seleit @aliseleit.bsky.social · 20/04/2026
Really cool work ! Love the strong scaling of ZGA timing to genome size and egg volume. It's so simple and elegant. Highlights the strength of taking a comparative approach
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Manuel Irimia @mirimiam.bsky.social · 20/04/2026
Do you want to know when your favorite species activates its genome? Just input its genome size (🧬 in bp) and egg volumen (🥚 in um3) here! ZGA_onset = -2.37 * log10(gDNA/EggVol) + 11.74
media.tenor.com
a cartoon of spongebob saying magic with his hands up
ALT: a cartoon of spongebob saying magic with his hands up
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Cnidarian developmental mechanisms group @clytia-vlfr.bsky.social · 20/04/2026
This fits the general principle of ZGA being triggered by a 'universal' Genome: Cytoplasm ratio across animals! - and thus a highly conserved mechanism involving titration of a maternal cytoplasmic factor on chromatin.
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Cnidarian developmental mechanisms group @clytia-vlfr.bsky.social · 20/04/2026
So, by providing staged embryo mRNA for this beautiful wide comparative study, we now know that zygotic gene activation in Clytia occurs in the early blastula with 512 cells, at around 5hpf (Here termed ZGA cell cycle 9).
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Zebrafish Rock! @zebrafishrock.bsky.social · 20/04/2026
“Here, we generated a comprehensive transcriptomic atlas of early embryogenesis from 61 animal species, spanning 13 phyla. By applying a unified computational framework, we systematically inferred the timing of ZGA across species.” This is a big one from @mirimiam.bsky.social et al. 🔥🧪
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Manuel Irimia @mirimiam.bsky.social · 20/04/2026
Thrilled to present our comparative study on the evolution of zygotic genome activation (ZGA)!! 🥚🧬 Amazing PhD work of @campobes.bsky.social together with @fedemantica.bsky.social and many collaborators! @melisupf.bsky.social @crg.eu. Thread below 1/15 www.biorxiv.org/content/10.6...
biorxiv.org
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Manuel Irimia @mirimiam.bsky.social · 17/04/2026
A terrible, unfair solution to a real, pressing problem.
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EVOMG-Doctoral Network @evomg-dn.bsky.social · 09/04/2026
We’ve reopened the call for a PhD position with Juana Diez at @melisupf.bsky.social within the EVOMG-DN project. 🧬 Viral Codon Usage: A Novel Readout of Virus Evolution and Host Interaction 🗓 Deadline: 10 May 2026 👉 Apply here: www.evomg-dn.eu/call-for-app...
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Ulrich Braunschweig @braunschweig.bsky.social · 26/03/2026
Alu repeats have played important roles in the evolution of (alternative) splicing via exonization and in other ways. In this paper, we show that they mediate interactions across exons to loop them out. Alus inserted this way in evolution render exons alternative. bit.ly/4t8Yahh 1/2
bit.ly
Alu-mediated RNA duplexes are associated with widespread exon skipping across primate transcriptomes - Genome Biology
Alternative splicing patterns have diverged rapidly during vertebrate evolution. By integrating genome-wide predictions of stable RNA duplexes, alternative splicing profiles, and proximity ligation-de...
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Darío Lupiáñez @dariloops.bsky.social · 06/03/2026
🚨 Job Alert - Please share! 🙏 Interested in 3D gene regulation in development & evolution? 🤓🧬 💥 Our lab at @cabd-upo-csic.bsky.social is expanding! We’re recruiting: ✅ PhD students ✅ Postdocs 💻🧪 Experimental or computational backgrounds welcome 👇 Details below
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The EMBO Journal @embojournal.org · 27/02/2026
Molecular #evolution of animal #aging: A field perspective explores the impact of evolution on aging and offers a multi-angle view on longevity variation across model organisms and environments link.springer.com/article/10.1...
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Manuel Irimia @mirimiam.bsky.social · 02/03/2026
🚨🧬🚨 We're looking for a specialized Research Assistant to spearhead a project aimed at exploring new RNA therapeutics in diabetes and other metabolic disorders. Junior or Senior, we're hoping to recruit a highly motivated and self-driven scientist interested in both basic and applied science. 🦄
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Jose Tubio’s lab - Mobile Genomes @mobilegenomes.bsky.social · 26/02/2026
Today in @science.org: We are pleased to present our last work entitled: "Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis" by Zumalave et al. www.science.org/doi/10.1126/...
science.org
Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis
LINE-1 (L1) retrotransposition generates somatic genomic variation in human cancer, but short-read sequencing has limited our understanding of its structural consequences and dynamics. Using long-read...
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Tugce Aktas @aktast.bsky.social · 25/02/2026
Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social doi.org/10.1016/j.ce... Read the thread👇 for the highlights of our findings.
doi.org
Redirecting
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Manuel Irimia @mirimiam.bsky.social · 23/02/2026
Great opportunity for 2 bioinformaticians! Come work with us at @melisupf.bsky.social ! 😉 Please RT! 🙏
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UPF Medicine and Life Sciences @melisupf.bsky.social · 03/02/2026
#Transfer UPF’s SPLICE-BETA project receives an ERC Proof of Concept Grant to develop a new treatment targeting the root cause of #Diabetes Congrats to the team led by @mirimiam.bsky.social & Jonas Juan cc @erc.europa.eu @upf.edu @prbb.org tuit.cat/7kLHr
tuit.cat
UPF’s SPLICE-BETA project receives an ERC Proof of Concept Grant to develop a new treatment targeting the root cause of diabetes
El projecte obté 150.000 euros del Consell Europeu de Recerca per impulsar un possible tractament capaç de restaurar la funció de les cèl·lules del pàncrees encarregades de produir insulina. Un pas en...
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Servei de Recerca de la UPF @sdrecercaupf.bsky.social · 27/01/2026
We are delighted to announce that @mirimiam.bsky.social (@melisupf.bsky.social) has been awarded one Proof of Concept Grant to work on RNA splicing therapeutics for beta cell dysfunction and diabetes.
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Isabel Almudi @isabelalmudi.bsky.social · 25/01/2026
Back in BCN after an great week in Valencia, 1st meeting of #EvoDevOmics network with @mirimiam.bsky.social @anariesgo.bsky.social @evodevogenomeub.bsky.social @patrialvarezcam.bsky.social @jpascualanaya.bsky.social @phylobrain.bsky.social @fany-real.bsky.social @imaeso.bsky.social & Nuria Flames
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EvodevogenomeUB- Cañestro’s lab @evodevogenomeub.bsky.social · 25/01/2026
1st #EvoDevOmics meeting🍊 What a terrific team @isabelalmudi.bsky.social @mirimiam.bsky.social @anariesgo.bsky.social @patrialvarezcam.bsky.social @jpascualanaya.bsky.social @phylobrain.bsky.social @fany-real.bsky.social Núria🔥 Nacho and more. What great hosts🥘 @hector-escriva.bsky.social & Steph
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Gallego Lab @gallegolab.bsky.social · 16/01/2026
0/10 🥳 our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaño-Díez labs #Quantitative_Cell_Biology Continuum architecture dynamics of vesicle tethering in exocytosis www.cell.com/cell/fulltex...
cell.com
Continuum architecture dynamics of vesicle tethering in exocytosis
Data from complementary imaging techniques were integrated into a model that resolves the dynamic exocyst ensemble and membrane architecture during exocytosis, an essential cellular pathway. Sec18 med...
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Martínez Morales Lab @jrmarmor.bsky.social · 12/01/2026
We are looking for a Bioinformatician (both graduate and postdoctoral levels) to join our lab. Please help us spread the word about this opportunity! Applicants should submit their motivation letter, full CV and academic record to Juan R. Martínez-Morales: jrmarmor@upo.es
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imaeso.bsky.social @imaeso.bsky.social · 07/01/2026
Our work on the evolution of the regulatory genome of echinoderms is now out in @natecoevo.nature.com. Led by my former PhD Marta Magri, Danila Voronov & Saoirse Foley. Great collaboration of Arnone, Hinman & Maeso labs, started long time ago with our missed José Luis Gomez-Skarmeta: rdcu.be/eXX8l
rdcu.be
Deep conservation of cis-regulatory elements and chromatin organization in echinoderms uncover ancestral regulatory features of animal genomes
Nature Ecology & Evolution - Analysis of the 3D chromatin architecture and cis-regulatory elements in a sea urchin and a sea star reveals mechanisms of 3D chromatin organization in echinoderms...
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Arnone Lab @arnonelab.bsky.social · 07/01/2026
Exciting news to start the new year! We’re thrilled to see this work finally out in @natecoevo.nature.com, the result of a major collaboration between my lab and the labs of Veronica Hinman and Nacho Maeso, began many years ago with the dear José Luis Gómez-Skarmeta. www.nature.com/articles/s41...
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Arnau Sebé-Pedrós @arnausebe.bsky.social · 02/01/2026
Open Senior Bioinformatician position at @sangerinstitute.bsky.social Tree of Life, to work on the Biodiversity Cell Atlas initiative with @marakat.bsky.social and me. 📅 Apply by January 18 🔗 sanger.wd103.myworkdayjobs.com/en-US/Wellco... Please share with anyone who might be interested!
sanger.wd103.myworkdayjobs.com
Senior Bioinformatician - Biodiversity Cell Atlas
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
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