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Zechner Lab

@zechnerlab.bsky.social
563 followers 291 following 9 posts

Research group at SISSA / Trieste. Interested in stochastic processes in biology & biophysics. Posts by C. Zechner.

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Anders Sejr Hansen @andersshansen.bsky.social · 30/06/2026
Excited to see James' Genome-wide Absolute Quantification of Looping paper out in @natsmb.nature.com : www.nature.com/articles/s41... This has been in collaboration with @lucagiorgetti.bsky.social @leonidmirny.bsky.social @zechnerlab.bsky.social labs. Brief thread below on some key updates
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Anders Sejr Hansen @andersshansen.bsky.social · 22/06/2026
(1/n) Very excited to share tri-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack: Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)? A: Transient E-P contact (~25-42 nm lasting ~10-20 sec): www.biorxiv.org/content/10.6...
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Anders Sejr Hansen @andersshansen.bsky.social · 05/05/2026
(1/n) Super excited to share that our preprint is out today in @natsmb.nature.com with a new name "Integrated MINFLUX tracking reveals two distinct chromatin dynamics classes across cell types" and more than 2x more data: www.nature.com/articles/s41... See also MIT News news.mit.edu/2026/how-chr...
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dimitristypas.bsky.social @dimitristypas.bsky.social · 04/05/2026
www.nature.com/articles/s41... An insighful study, leveraging MINFLUX to study chromatin dynamics by the @andersshansen.bsky.social lab @natsmb.nature.com . I am left wondering what if how we model chromatin with polymer simualtions needs rethinking, but surely many interesting findings here.
nature.com
Integrated MINFLUX tracking reveals two distinct chromatin dynamics classes across cell types - Nature Structural & Molecular Biology
Chromatin dynamics govern search times between DNA elements. Using integrated MINFLUX imaging, Mazzocca, Narducci, Grosse-Holz and colleagues track chromatin dynamics over seven orders of magnitude in...
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Benjamin Towbin @betowbin.bsky.social · 08/04/2026
Join us at the LS2 #Theory #across #Biology chalk talk symposium! 12 June 2026 in Bern, CH. @lifesciswitzerland.bsky.social No movies that fail, no Mac to PC issues. Only the best ideas and exchange across biology from evolution and ecology to physics of life. meetings.ls2.ch/theory-acros...
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Anders Sejr Hansen @andersshansen.bsky.social · 22/03/2026
Kinetic proofreading as a mechanism for transcriptional specificity: www.biorxiv.org/content/10.6... Very nice follow up to their review from last year genesdev.cshlp.org/content/39/1... Non-equilibrium models may be key to understanding specificity in transcriptional regulation!
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Paolo De Los Rios @paolodelosrios.bsky.social · 21/03/2026
Postdoc opening with us at EPFL! Experimental project on how ATP driven chaperone cycles keep proteins out of equilibrium. We will quantify energy use, kinetics, and functional outcomes, including clients whose native-like functional state is stable only by sustained chaperone action.
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Daniel Jost - Physical Biology of Chromatin group @djost-physbiol.bsky.social · 23/02/2026
Our work on the interplay between loop extrusion and chromatin mechanics is finally out in @physrevresearch.bsky.social . Congrats @hosseinsalari.bsky.social for the hard work ! 👏 journals.aps.org/prresearch/a...
journals.aps.org
Active loop extrusion modulates the mechanical response of chromatin under tension
Chromosomes are complex biopolymers folded into dynamic loops via a loop-extrusion process and may experience various mechanical forces in vivo. We develop a force-dependent model of chromatin loop ex...
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Anders Sejr Hansen @andersshansen.bsky.social · 11/02/2026
Come on join us! We are searching for the next technical associate to join our lab ~Summer 2026. This could be a great position for someone who is graduating this spring and is looking for 2 more years of research experience before starting their PhD: careers.peopleclick.com/careerscp/cl...
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EMBO @embo.org · 02/02/2026
The EMBO Young Investigator Network consists of young investigators, installation grantees and global investigators. 🧪 Find more information on the individual programmes here: www.embo.org/the-embo-communities/e… #LifeSciences #research #funding
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Brugues Lab @brugueslab.bsky.social · 07/01/2026
Excited to share Alison's @alisonkickuth.bsky.social paper from the lab out in @nature.com this week! We uncovered how a mechanical ratchet mechanism drives cytokinesis in early #zebrafish embryos. Read more in this thread 🧵 and at www.nature.com/articles/s41... 🤩 @poldresden.bsky.social @mpi-cbg.de
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Job Dekker @jobdekker.bsky.social · 22/12/2025
See this recent paper by @andersshansen.bsky.social that discovers similar microcompartmentalization during mitotic exit: www.nature.com/articles/s41...
nature.com
Dynamics of microcompartment formation at the mitosis-to-G1 transition - Nature Structural & Molecular Biology
Goel et al. produce high-resolution three-dimensional genome structure mapping from mitosis to G1 phase to show unseen interactions between enhancers and promoters in prometaphase. Polymer modeling in...
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Will Shoemaker @shoestrapped.bsky.social · 18/12/2025
An incredible ICTP initiative is our Postgraduate Diploma Programme. Rigorous one-year pre-PhD training for students from the Global South. I have personally seen this program transform the lives of those in the quant life sciences. Due Feb. 28 2026. Please share widely. www.ictp.it/news/2025/11...
ictp.it
Call for Applications, Postgraduate Diploma Programme | ICTP
Are you a student who dreams of earning a PhD in physics or mathematics, but who lives in a country lacking such opportunities? ICTP could be your first step on the path to attaining a PhD.
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Zwicker Group @zwickergroup.bsky.social · 15/12/2025
Since more than a decade, our group has been exploring chemically active droplets, which are exciting since their size can be controlled. Yet, we still do not fully understand this control even in the simplest models. Until a new preprint (arxiv.org/abs/2512.02542) spearheaded by postdoc Guido...
arxiv.org
Size control guidelines for chemically active droplets
Biological cells and synthetic analogues use liquid-liquid phase separation to dynamically compartmentalize their environment for various applications. In many cases, multiple droplets need to coexist...
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Timothy O'Leary @timothyoleary.bsky.social · 03/12/2025
We are opening a FACULTY POSITION (tenure track, permanent) in the University of Cambridge at the interface of control and biology, interpreted broadly. Theorists and wet lab quantitative biologists with backgrounds in control, EE, applied math, ... apply by Jan 28! www.cam.ac.uk/jobs/univers...
cam.ac.uk
University Assistant/Associate Professor in Control Theory and Systems Biology
Applications are invited for a University Assistant/Associate Professorship in the broad area of Control Theory and Systems Biology. The successful candidate will join the Control Group
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Toth-Petroczy lab @tothpetroczylab.bsky.social · 01/12/2025
I am honored and proud to work with my amazing group @mpi-cbg.de and @csbdresden.bsky.social 🥰 🧬. Thanks to all my colleagues for the wonderful scientific environment. And thank you @kboes.bsky.social for preparing this superb video! 🤩
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Katie Mack @astrokatie.com · 30/11/2025
The most precious commodity you have is your attention. You don’t have to waste it on poor-faith debates or arguments with strangers if you don’t think they’ll be productive. You can prioritize the things that matter to you and make your life richer.
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Giovanni Bussi @bussigio.bsky.social · 28/11/2025
I’m very excited to start this project — it brings together ideas that matured over many years and opens a long-term path for innovation in RNA modelling. 🍾 🧬
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Max Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · 27/11/2025
One of our founding directors Anthony Hyman @hymanlab.bsky.social will become @embl.org Director General: www.mpi-cbg.de/news-outreac...
mpi-cbg.de
Anthony Hyman to become next EMBL Director General
Founding Director of MPI-CBG will lead Europe's life sciences laboratory
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Anders Sejr Hansen @andersshansen.bsky.social · 15/11/2025
Wonderful to see the beautiful preprint from Sabate et al now published - TADs are also dynamic structures in human cells, with remarkably similar parameters between mESCs and HCT116 cells www.nature.com/articles/s41...
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efe ilker @efeilker-phys.bsky.social · 27/10/2025
Two 2-year postdoc positions in my theory group — for studying the interplay between metabolism and morphogenesis at the edge of the Calanques and the Mediterranean. More information can be found on: euraxess.ec.europa.eu/jobs/381176 #biophysics
euraxess.ec.europa.eu
Postdoc in Theoretical Biophysics
Two postdoc positions (each for two years, funded by Amidex Foundation) are available in theoretical biophysics within the theory group at DyNaMo (Aix-Marseille University).
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Luca Giorgetti lab @FMI @lucagiorgetti.bsky.social · 24/09/2025
Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication. www.biorxiv.org/content/10.1... A🧵👇
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Anaïs Bailles @anaisbailles.bsky.social · 12/09/2025
Thanks a lot to @elisecutts.bsky.social for nicely highlighting and putting in context our article! It was very interesting to discuss together, notably about the analogies between the emergence of order in Hydra and other physical phenomena.
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André Nadler @nadlerlab.bsky.social · 22/08/2025
Great work! Congratulations you all & especially to @carldmodes.bsky.social who joined today after a lot of arm twisting by Caren...
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André Nadler @nadlerlab.bsky.social · 21/08/2025
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...
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Anaïs Bailles @anaisbailles.bsky.social · 13/08/2025
Our beautiful Hydra made the cover!!! 😍😍😍 An experiment performed by Pavel Mejstrik with a HCR protocol by @giuliaserafini.bsky.social, @paveltomancak.bsky.social lab @mpi-cbg.de Actin fibers in blue, nuclei in orange.
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paveltomancak.bsky.social @paveltomancak.bsky.social · 06/08/2025
Our first #Hydra paper. @anaisbailles.bsky.social all the way, with crucial theory contributions from Carl Modes and @zechnerlab.bsky.social Hydra maintenance by Heino Andreas and HCR by Giulia Serafini. Teamwork. Many thanks to the generous Hydra research community.
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Max Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · 05/08/2025
Stretching the immortal Hydra. Publication by @paveltomancak.bsky.social group with Carl Modes @mpi-cbg.de & @zechnerlab.bsky.social shows how cells can create a new organism from scratch by coordinating their mechanical properties. @anaisbailles.bsky.social @pnas.org www.mpi-cbg.de/news-outreac...
mpi-cbg.de
Stretching the immortal Hydra
Dresden researchers show how cells can create a new organism from scratch by coordinating their mechanical properties.
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Max Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · 26/06/2025
Novel Research in Biological Artificial Intelligence: Expressions of interest and nominations for a Max Planck Director to lead research in the field of Biological Artificial Intelligence @mpi-cbg.de and @csbdresden.bsky.social. More information: www.mpi-cbg.de/news-outreac...
mpi-cbg.de
Novel Research in Biological Artificial Intelligence
Expressions of interest and nominations for a Max Planck Director to lead research in the field of Biological Artificial Intelligence.
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Heather Harrington @haharrington.bsky.social · 26/06/2025
We are searching for an AI researcher in lab automation, statistical ML and (theoretical) physics AI for bio/med. Expression of interest and nominations welcome!!!
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Luca Giorgetti lab @FMI @lucagiorgetti.bsky.social · 26/06/2025
We are looking for a research assistant to join our lab and support ongoing projects with genome engineering in mouse embryonic stem cells! Please get in touch if you are interested. www.fmi.ch/education-ca...
fmi.ch
Friedrich Miescher Institute, open position
Friedrich Miescher Institute, open position
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Anders Sejr Hansen @andersshansen.bsky.social · 15/05/2025
(1/n) Thread @matteomazzocca.bsky.social @domenicnarducci.bsky.social Simon Grosse-Holz @jessematthias.bsky.social preprint Q: how does chromatin move? Using MINFLUX, SPT & SRLCI, we track chromatin dynamics across 7 orders of magnitude in time to provide answers www.biorxiv.org/content/10.1...
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Zechner Lab @zechnerlab.bsky.social · 28/03/2025
Many congratulations to Anne for defending her PhD this week…excellent results and presentation! We wish you all the best for your future career!
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Giovanni Bussi @bussigio.bsky.social · 27/03/2025
We are finalizing the program of the @cecamevents.bsky.social RNA modelling across scales www.cecam.org/workshop-det... at SISSA, Trieste, Italy, May 19-22. Please note that we still have a few slots for in person attendance. We will accept applications for the next few weeks, until fully booked!
cecam.org
CECAM - RNA modelling across scales
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paveltomancak.bsky.social @paveltomancak.bsky.social · 02/03/2025
Come to #Prague for #Woodstock2025. What is it? A scientific conference unlike any other. Think #BurningMan or #MusicFestival but #science themed. It'll have two parts - decentralised sessions spread in #Prague (sightsee as you move around) & #campsite event to wrap it up (1/7)
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Max Planck Institute for the Physics of Complex Systems @mpipks.bsky.social · 29/01/2025
"Cacio e pepe" physics: In arxiv.org/abs/2501.00536v1, eight Italian scientists from the Max Planck Institute for the Physics of Complex Systems explain the physics behind a perfect dish of "cacio e pepe" and how to eschew the dreaded "mozzarella phase" - work featured @nytimes.com.
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Zechner Lab @zechnerlab.bsky.social · 13/02/2025
Congratulations Tommaso for an excellent PhD defense! Very well done!
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Zechner Lab @zechnerlab.bsky.social · 12/02/2025
Excited to share our new work with Frank Jülicher on noise control & concentration buffering in intracellular condensates! There has been confusion about these concepts, which we aim to address in this paper. www.cell.com/cell-systems...
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Giovanni Bussi @bussigio.bsky.social · 04/02/2025
Starting the new season of seminars in Molecular and Statistical Biophysics at SISSA! Gareth Tribello today gave a talk with title “Reconnaissance Metadynamics Rides Again”
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Zechner Lab @zechnerlab.bsky.social · 17/01/2025
Please share! There are two postdoc opportunities at the Molecular and Statistical Biophysics group at SISSA. Join us in beautiful Trieste! More information at msb.sissa.it/join-us/
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Anders Sejr Hansen @andersshansen.bsky.social · 16/01/2025
Excited to share James Jusuf's preprint: By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%) We quantify mESC 36k loops: <loops> are generally rare (2.3%) www.biorxiv.org/content/10.1...
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Bussi Lab @bussilab.org · 15/01/2025
📢 Post-doc opportunity alert! Join the Molecular and Statistical Biophysics group at SISSA. Choose your mentor from Giovanni Bussi, Cristian Micheletti, or Angelo Rosa, or collaborate across these groups. www.bussilab.org/joinus#postd... #joinus Please reshare!
bussilab.org
Join Us
RNA, molecular dynamics, and more
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Zechner Lab @zechnerlab.bsky.social · 02/12/2024
Exciting news! As of today, our group is part of SISSA in Trieste. Time to say THANK YOU to all current and past group members, collaborators and mentors and to @mpicbg.bsky.social for hosting us for 8 amazing years! If you are interested in working with us in Trieste, please get in touch!
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